Glycine receptor subtypes and their roles in nociception and chronic pain
Author
dc.contributor.author
San Martín, Victoria
Author
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Sazo, Anggelo
Author
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Utreras Puratich, Elias
Author
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Moraga Cid, Gustavo
Author
dc.contributor.author
Yévenes, Gonzalo
Admission date
dc.date.accessioned
2022-06-07T15:28:52Z
Available date
dc.date.available
2022-06-07T15:28:52Z
Publication date
dc.date.issued
2022
Cita de ítem
dc.identifier.citation
Frontiers in Molecular Neuroscience March 2022 Vol. 15 Article 848642
es_ES
Identifier
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10.3389/fnmol.2022.848642
Identifier
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https://repositorio.uchile.cl/handle/2250/185885
Abstract
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Disruption of the inhibitory control provided by the glycinergic system is one of the major mechanisms underlying chronic pain. In line with this concept, recent studies have provided robust proof that pharmacological intervention of glycine receptors (GlyRs) restores the inhibitory function and exerts anti-nociceptive effects on preclinical models of chronic pain. A targeted regulation of the glycinergic system requires the identification of the GlyR subtypes involved in chronic pain states. Nevertheless, the roles of individual GlyR subunits in nociception and in chronic pain are yet not well defined. This review aims to provide a systematic outline on the contribution of GlyR subtypes in chronic pain mechanisms, with a particular focus on molecular pathways of spinal glycinergic dis-inhibition mediated by post-translational modifications at the receptor level. The current experimental evidence has shown that phosphorylation of synaptic alpha 1 beta and alpha 3 beta GlyRs are involved in processes of spinal glycinergic dis-inhibition triggered by chronic inflammatory pain. On the other hand, the participation of alpha 2-containing GlyRs and of beta subunits in pain signaling have been less studied and remain undefined. Although many questions in the field are still unresolved, future progress in GlyR research may soon open new exciting avenues into understanding and controlling chronic pain.
es_ES
Patrocinador
dc.description.sponsorship
ANID-FONDECYT 1211095
1191552
1211082
Millennium Nucleus for the Study of Pain (MiNuSPain)
Millennium Science Initiative of the Ministry of Science, Technology, Knowledge and Innovation, Chile
es_ES
Lenguage
dc.language.iso
en
es_ES
Publisher
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Frontiers Media
es_ES
Type of license
dc.rights
Attribution-NonCommercial-NoDerivs 3.0 United States