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Authordc.contributor.authorSan Martín, Victoria
Authordc.contributor.authorSazo, Anggelo
Authordc.contributor.authorUtreras Puratich, Elias
Authordc.contributor.authorMoraga Cid, Gustavo
Authordc.contributor.authorYévenes, Gonzalo
Admission datedc.date.accessioned2022-06-07T15:28:52Z
Available datedc.date.available2022-06-07T15:28:52Z
Publication datedc.date.issued2022
Cita de ítemdc.identifier.citationFrontiers in Molecular Neuroscience March 2022 Vol. 15 Article 848642es_ES
Identifierdc.identifier.other10.3389/fnmol.2022.848642
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/185885
Abstractdc.description.abstractDisruption of the inhibitory control provided by the glycinergic system is one of the major mechanisms underlying chronic pain. In line with this concept, recent studies have provided robust proof that pharmacological intervention of glycine receptors (GlyRs) restores the inhibitory function and exerts anti-nociceptive effects on preclinical models of chronic pain. A targeted regulation of the glycinergic system requires the identification of the GlyR subtypes involved in chronic pain states. Nevertheless, the roles of individual GlyR subunits in nociception and in chronic pain are yet not well defined. This review aims to provide a systematic outline on the contribution of GlyR subtypes in chronic pain mechanisms, with a particular focus on molecular pathways of spinal glycinergic dis-inhibition mediated by post-translational modifications at the receptor level. The current experimental evidence has shown that phosphorylation of synaptic alpha 1 beta and alpha 3 beta GlyRs are involved in processes of spinal glycinergic dis-inhibition triggered by chronic inflammatory pain. On the other hand, the participation of alpha 2-containing GlyRs and of beta subunits in pain signaling have been less studied and remain undefined. Although many questions in the field are still unresolved, future progress in GlyR research may soon open new exciting avenues into understanding and controlling chronic pain.es_ES
Patrocinadordc.description.sponsorshipANID-FONDECYT 1211095 1191552 1211082 Millennium Nucleus for the Study of Pain (MiNuSPain) Millennium Science Initiative of the Ministry of Science, Technology, Knowledge and Innovation, Chilees_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherFrontiers Mediaes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
Sourcedc.sourceFrontiers in Molecular Neurosciencees_ES
Keywordsdc.subjectGlycine receptor (GlyR)es_ES
Keywordsdc.subjectChronic paines_ES
Keywordsdc.subjectNociceptiones_ES
Keywordsdc.subjectPhosphorylationes_ES
Keywordsdc.subjectSynaptic plasticityes_ES
Títulodc.titleGlycine receptor subtypes and their roles in nociception and chronic paines_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Catalogueruchile.catalogadorapces_ES
Indexationuchile.indexArtículo de publícación WoSes_ES


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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States