Circulating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults
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2022Metadata
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Merchán Ramírez, Elisa
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Circulating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults
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Thyroid dysfunction is associated with classic cardiometabolic risk factors in humans. However, this relationship remains unclear in young euthyroid adults. The present work examines the associations of circulating thyroid hormones (THs) and thyroid-stimulating hormone (TSH) concentrations with body composition and cardiometabolic risk factors in young euthyroid adults. A total of 106 sedentary, euthyroid adults (72 women; 22 +/- 2 years old) participated in this cross-sectional study. THs and TSH serum concentrations were determined in fasting conditions (6 h). Body composition (fat mass (FM), lean mass (LM), and visceral adipose tissue (VAT)) was determined by dual-energy X-ray absorptiometry, anthropometric parameters (weight, height, and waist circumference) were measured, and neck adipose tissue mass was quantified through computed tomography (CT) scanning. Cardiometabolic risk factors including fasting glucose and lipid metabolism markers, hepatic phosphatase and transaminases, and blood pressure were also assessed. Free triiodothyronine (FT3) concentration was positively associated with body mass index, LM, VAT, and waist circumference (all P <= 0.038). FT3 was also associated with glucose, insulin, HOMA-IR, fatty liver index, and blood pressure (all P < 0.024). All the associations were attenuated when adjusting for sex. In contrast, we found no associations of TSH or free thyroxine with any body composition parameter or cardiometabolic risk factors. In conclusion, FT3 is associated with central adiposity and cardiometabolic risk factors including insulin resistance, fatty liver index, and mean, systolic and diastolic blood pressure in young euthyroid adults.
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Universidad de Granada/CBUA
Spanish Government PI13/01393
Retos de la Sociedad program DEP2016-79512-R
European Commission
Spanish Government FPU13/04365
Fundacion Iberoamericana de Nutricion (FINUT)
Redes Tematicas de Investigacion Cooperativa RETIC Red SAMID RD16/0022
AstraZeneca
University of Granada Plan Propio de Investigacion 2016-Excellence actions: Unit of Excellence on Exercise and Health (UCEES)
Plan Propio de Investigacion 2018-the Programa Contratos-Puente
Contratos Perfeccionamiento de Doctores
Junta de Andalucia
Consejeria de Conocimiento, Investigacion y Universidades (ERDF) SOMM17/6107/UGR
Fundacion Alfonso Martin Escudero
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Artículo de publícación WoS
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Journal of Physiology and Biochemistry Early Access APR 2022 Indexed 2022-04-21
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