Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico
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2021Metadata
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Tumani Karmy, María Fernanda
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Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico
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Abstract
Non-alcoholic fatty liver disease (NAFLD) encompasses a wide
spectrum of hepatic pathologies ranging from simple steatosis (SS) to
hepatocellular carcinoma. Intestinal microbiota (IM) is composed of
trillions of microorganisms existing in the gut. It has 150 times more
genes than the host. Changes in the composition and function of the
IM are associated with different diseases, including NAFLD. In this
condition, IM could have a pathogenic role through different mechanisms
such as energy salvaging from food, an inflammatory stimulus,
a modulation of the innate immune system, regulation of bile acid
turnover, alteration of choline metabolism and increasing endogenous
ethanol levels. This review is an update on the role of the intestinal
microbiota in NAFLD and the possible mechanisms involved.
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Rev Med Chile 2021; 149: 570-579
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