Now showing items 561-580 of 11583

    • Macias Mendoza, Marlon; Montes Robledo, Alfredo; Arteta Acosta, Cindy; Baldiris Avila, Rosa; Coronell Rodríguez, Wilfrido (Elsevier, 2022)
      The bacterium Neisseria meningitidis, a strictly human pathogen, can cause meningitis, meningococcemia, sepsis, and death; repeatedly it scause outbreaks around the world. The frequency of asymptomatic carriage is often ...
    • Núñez Figueroa, Paulina; Castro, Fabiola; Mezzano, Gabriel; Quera, Rodrigo; Díaz, Diego; Castro, Lorena (Baishideng Publishing, 2022)
      Inflammatory bowel diseases (IBD) are associated with various hepatobiliary disorders. They can occur at any moment in the course of the disease or associated with the treatment. The prevalence of liver dysfunction can ...
    • Oróstica Arévalo, Maria Lorena; Astorga Leiva, Isis; Plaza Parrochia, Francisca; Poblete Rivas, Cristian; Carvajal Gavilán, Rodrigo; García Angulo, Víctor; Romero Osses, Carmen; Vega Blanco, María Margarita (MDPI, 2022)
      Polycystic ovary syndrome (PCOS) is an endocrine/metabolic disorder associated with insulin resistance (IR) and obesity. Endometria from women with PCOS present failures in insulin action, glucose uptake and signaling of ...
    • Maldonado Maldonado, Edio; Morales Pisón, Sebastian; Urbina, Fabiola; Solari Illescas, Aldo (MDPI, 2022)
      Chagas disease is caused by the protozoan Trypanosoma cruzi and is endemic to Central and South America. However, it has spread around the world and affects several million people. Treatment with currently available drugs ...
    • Pereira Montecinos, Camila; Toro Ascuy, Daniela; Ananías Sáez, Catarina; Gaete Argel, Aracelly; Rojas Fuentes, Cecilia; Riquelme Barrios, Sebastián; Rojas Araya, Bárbara; García de Gracia, Francisco; Aguilera Cortés, Paulina; Chnaiderman Figueroa, Jonas; Acevedo Acevedo, Mónica; Valiente Echeverría, Fernando; Soto Rifo, Ricardo (Oxford University Press, 2022)
      During retroviral replication, the full-length RNA serves both as mRNA and genomic RNA. However, the mechanisms by which the HIV-1 Gag protein selects the two RNA molecules that will be packaged into nascent virions remain ...
    • Lallas, A.; Martínez, G.; Arceu, M.; Kyrgidis, A.; Liopyris, K.; Brancaccio, G.; Longo, C.; Errichetti, E.; Sgouros, D.; Papageorgiou, C.; Fotiadou, C.; Siskou, S.; Manoli, S. M.; Sotiriou, E.; Ioannides, D.; Katoulis, A.; Lazaridou, E.; Todorovska, V.; Argenziano, G.; Apalla, Z. (Wiley, 2022)
      Background Squamous cell carcinoma of the lip accounts for 20% of all oral carcinomas. Its diagnosis may be challenging because it clinically resembles actinic cheilitis and inflammatory lesions of the lips. Objectives To ...
    • Pérez Castro, Pablo; Salas, Sofia P. (Wiley, 2021)
      Organ transplantation is a lifesaving procedure for end-organ damage and remains up to today as the most cost-effective alternative to treat these conditions. However, the main limitation to performing organ transplants ...
    • Leiva, Lorenzo Eugenio; Katz Zondek, Assaf (MDPI, 2022)
      In bacteria, the translation of genetic information can begin through at least three different mechanisms: canonical or Shine-Dalgarno-led initiation, readthrough or 70S scanning initiation, or leaderless initiation. Here, ...
    • García González, Paulina; Fernández, Dominique; Gutiérrez Cabrera, Diane; Parra Cordero, Mauro; Osorio Olivares, Fabiola (Wiley, 2022)
      The intracellular mechanisms safeguarding DC function are of biomedical interest in several immune-related diseases. Type 1 conventional DCs (cDC1s) are prominent targets of immunotherapy typified by constitutive activation ...
    • Anza Miranda, Fernanda; Aguilar Vidal, Enzo (Elsevier, 2022)
      Background: The activation of the medial olivocochlear reflex reduces the cochlear gain, which is manifested perceptually as decreased auditory sensitivity. However, it has remained unclear whether the extent of this ...
    • González, Andrea; Singh, Sandeep Kumar; Churruca Muñoz, Macarena; Maccioni Baraona, Ricardo Benjamín (MDPI, 2022)
      Alzheimer's disease (AD) is a multifactorial neurodegenerative disease characterized by progressive cognitive impairment, apathy, and neuropsychiatric disorders. Two main pathological hallmarks have been described: ...
    • Acuña Avila, Mirta; Benadof Fuentes, Dona; Yohannessen Vásquez, Karla; Leiva, Yennybeth; Clement Campillo, Pascale (BMC, 2022)
      Background: Central nervous system (CNS) infection has been an ongoing concern in paediatrics. The FilmArray (R) Meningoencephalitis (FAME) panel has greater sensitivity in identifying the aetiology of CNS infections. This ...
    • Adeyemo, Adebowale; Balaconis, Mary K.; Darnes, Deanna R.; Fatumo, Segun; Granados Moreno, Palmira; Hodonsky, Chani J.; Inouye, Michael; Kanai, Masahiro; Kato, Kazuto; Knoppers, Bartha M.; Lewis, Anna C. F.; Martin, Alicia R.; McCarthy, Mark I.; Meyer, Michelle N.; Okada, Yukinori; Richards, J. Brent; Richter, Lucas; Ripatti, Samuli; Rotimi, Charles N.; Sanderson, Saskia C.; Sturm, Amy C.; Verdugo Salgado, Ricardo Alejandro; Widen, Elisabeth; Willer, Cristen J.; Wojcik, Genevieve L.; Zhou, Alicia (Nature Research, 2021)
      Polygenic risk scores (PRSs) aggregate the many small effects of alleles across the human genome to estimate the risk of a disease or disease-related trait for an individual. The potential benefits of PRSs include ...
    • Bosch Amate, X.; Vargas Mora, Pablo Andrés; Morgado Carrasco, D. (Elsevier, 2021)
    • Rojas Erazo, Camilo Omar; Valenzuela Ahumada, Fernando Alfredo; Carreño Toro, Laura Elisa; González Coloma, Francisco (Mattioli 1885, Italy, 2021)
    • Neri, Piergiorgio; Herbort, Carl P.; Hedayatfar, Alireza; Tugal Tutkun, Ilknur; Cimino, Luca; Urzúa Salinas, Cristhian Alejandro; Papasavvas, Ioannis; Takeuchi, Masuru; Lages, Vania (Springer, 2022)
    • Hosiasson, Stefan; Beca, Juan Pablo; Vaisman Weinstein, Sergio (Elsevier, 2021)
      La historia de los inicios en Chile de la implementación nacional de las unidades de cuidados intensivos neonatales, y por ende de los inicios de la neonatología moderna en Chile, es de visionarios motivados exclusivamente ...
    • Pacheco, Rodrigo; Quezada, Sergio A.; Kalergis, Alexis M.; Becker, María Inés; Ferreira, Jorge; Ioannes, Alfredo E. de (Sociedad de Biología de Chile, 2021)
      Background: Urushiols are pro-electrophilic haptens that cause severe contact dermatitis mediated by CD8+ efector T-cells and downregulated by CD4+ T-cells. However, the molecular mechanism by which urushiols stimulate innate ...
    • Ibáñez, Agustín; Pina Escudero, Stefanie Danielle; Possin, Katherine L.; Quiroz, Yakeel T.; Aguzzoli Peres, Fernando; Slachevsky Chonchol, Andrea María; Sosa, Ana Luisa; Brucki, Sonia M. D.; Miller, Bruce L (Elsevier, 2021)
      The prevalence of dementia in Latin America and the Caribbean is growing rapidly, increasing the burden placed on caregivers. Exacerbated by fragile health-care systems, unstable economies, and extensive inequalities, ...
    • García González, Paulina; Tempio Sepúlveda, Fabián Ignacio; Fuentes, Camila; Merino, Consuelo; Vargas, Leonardo; Simon, Valeska; Ramírez Pereira, Mirliana; Rojas, Verónica; Tobar Almonacid, Eduardo Andres; Landskron Ramos, Glauben Tamara; Araya, Juan Pablo; Navarrete, Mariela; Bastías Oñate, Carla Belén; Tordecilla Fernández, Rocío Pilar; Varas, Macarena A.; Maturana, Pablo; Marcoleta Caldera, Andrés Esteban; Allende Connelly, Miguel Luis; Naves Pichuante, Rodrigo Antonio; Hermoso, Marcela Alejandra; Salazar Onfray, Flavio Andrés; López Nitsche, Mercedes Natalia; Bono Merino, María Rosa; Osorio Olivares, Fabiola Beatriz (Frontiers Media, 2021)
      The prognosis of severe COVID-19 patients has motivated research communities to uncover mechanisms of SARS-CoV-2 pathogenesis also on a regional level. In this work, we aimed to understand the immunological dynamics of ...