Bioaccessibility of lignans from flaxseed (Linum usitatissimum L.) determined by single-batch in vitro simulation of the digestive process
Author
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Fuentealba, Claudia
Author
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Figuerola Rivas, Fernando Emilio
es_CL
Author
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Estévez Alliende, Ana
es_CL
Author
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Bastías, José M.
es_CL
Author
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Muñoz, Ociel
es_CL
Admission date
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2014-12-15T12:13:11Z
Available date
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2014-12-15T12:13:11Z
Publication date
dc.date.issued
2014
Cita de ítem
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J Sci Food Agric 2014; 94: 1729–1738
en_US
Identifier
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DOI: 10.1002/jsfa.6482
Identifier
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https://repositorio.uchile.cl/handle/2250/120248
General note
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Artículo de publicación ISI
en_US
Abstract
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BACKGROUND: Flaxseed is an important source of lignan secoisolariciresinol diglucoside (SDG) and its aglycone,
secoisolariciresinol (SECO). These phenolic compounds can be metabolized to the mammalian lignans enterodiol (ED) and
enterolactone (EL) by human intestinal microflora. Flaxseed lignans are known for their potential health benefits, which are
attributed to their antioxidant and phytoestrogenic properties. The focus of this study was to determine the bioaccessibility of
plant and mammalian lignans in whole flaxseed (WF) and flaxseed flour (FF) throughout the entire digestive process. Moreover,
themetabolic activity of intestinalmicroflora was evaluated.
RESULTS: A single-batch in vitro simulation of the digestive process was performed, including fermentation by the intestinal
microflora in the colon. Bioaccessibility was calculated as (free lignan)/(total lignan). In digested WF, the bioaccessibility values
of SECO, ED and EL were 0.75%, 1.56% and 1.23%, respectively. Conversely, in digested FF, the bioaccessibility values of SDG,
ED and EL were 2.06%, 2.72% and 1.04%, respectively. The anaerobic count and short-chain fatty acids indicate that bacteria
survival and carbohydrate fermentation occurred.
CONCLUSION: The contents of both SDG and ED were significantly higher in digested FF than in digestedWF. FF facilitated the
action of intestinal bacteria to release SDG andmetabolize ED.
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Patrocinador
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This research was supported by the National Fund for Scientific
and Technological Development (FONDECYT) project 1080277.
Fuentealba obtained a CONICYT doctoral fellowship in 2009.