Now showing items 1-12 of 12

    • Autophagy and its impact on neurodegenerative diseases: new roles for TDP-43 and C9orf72 

      Budini, Mauricio; Buratti, Emanuele; Morselli, Eugenia; Criollo Céspedes, Alfredo (Frontiers, 2017-05-30)
      Autophagy is a catabolic mechanism where intracellular material is degraded by vesicular structures called autophagolysosomes. Autophagy is necessary to maintain the normal function of the central nervous system (CNS), ...
    • Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state? 

      Peña Oyarzún, Daniel; Bravo Sagua, Roberto; Díaz Vega, Alexis; Aleman, Larissa; Chiong Lay, Mario; Garcia, Lorena; Bambs, Claudia; Troncoso, Rodrigo; Cifuentes, Mariana; Morselli, Eugenia; Ferreccio, Catterina; Quest, Andrew F. G.; Criollo Céspedes, Alfredo; Lavandero González, Sergio (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; ...
    • Hyperosmotic stress stimulates autophagy via polycystin-2 

      Peña Oyarzún, Daniel; Troncoso Cotal, Rodrigo; Kretschmar, Catalina; Hernando, Cecilia; Budini, Mauricio; Morselli, Eugenia; Lavandero González, Sergio; Criollo Céspedes, Alfredo (Impact Journals, 2017)
      Various intracellular mechanisms are activated in response to stress, leading to adaptation or death. Autophagy, an intracellular process that promotes lysosomal degradation of proteins, is an adaptive response to several ...
    • IKK connects autophagy to major stress pathways 

      Criollo Céspedes, Alfredo; Senovilla, Laura; Authier, Hélène; Maiuri, Maria Chiara; Morselli, Eugenia; Vitale, Ilio; Kepp, Oliver; Tasdemir, Ezgi; Galluzzi, Lorenzo; Shen, Si; Tailler, Maximilien; Delahaye, Nicolas; Tesniere, Antoine; De Stefano, Daniela; Younes, Aména Ben; Harp (Taylor and Francis Inc., 2010)
      Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both ...
    • Impact of estrogens and estrogen receptor-alpha in brain lipid metabolism 

      Morselli, Eugenia; Santos, Roberta de Souza; Gao, Su; Avalos, Yenniffer; Criollo Céspedes, Alfredo; Palmer, Biff F.; Clegg, Deborah J. (American Physiological Society, 2018-07)
      Estrogens and their receptors play key roles in regulating body weight, energy expenditure, and metabolic homeostasis. It is known that lack of estrogens promotes increased food intake and induces the expansion of adipose ...
    • Impact of estrogens and estrogen receptor-α in brain lipid metabolism 

      Morselli, Eugenia; de Souza Santos, Roberta; Gao, Su; Ávalos, Yenniffer; Criollo Céspedes, Alfredo; Palmer, Biff F.; Clegg, Deborah J. (American Physiological Society, 2018)
      © 2018 American Physiological Society. All rights reserved. Estrogens and their receptors play key roles in regulating body weight, energy expenditure, and metabolic homeostasis. It is known that lack of estrogens promotes ...
    • Inhibition of autophagy by TAB2 and TAB3 

      Criollo Céspedes, Alfredo; Niso-Santano, Mireia; Malik, Shoaib Ahmad; Michaud, Mickael; Morselli, Eugenia; Mariño, Guillermo; Lachkar, Sylvie; Arkhipenko, Alexander V.; Harper, Francis; Pierron, Gérard; Rain, Jean Christophe; Ninomiya-Tsuji, Jun; Fuentes, José M.; Lavandero González, Sergio (2011)
      Autophagic responses are coupled to the activation of the inhibitor of NF-κB kinase (IKK). Here, we report that the essential autophagy mediator Beclin 1 and TGFβ-activated kinase 1 (TAK1)-binding proteins 2 and 3 (TAB2 ...
    • Polycystin-2-dependent control of cardiomyocyte autophagy 

      Criollo Céspedes, Alfredo; Altamirano, Francisco; Pedrozo Cibils, Zully; Schiattarella, Gabriele G.; Li, Dan L.; Rivera‐Mejias, Pablo; Sotomayor Flores, Cristian; Parra, Valentina; Villalobos, Elisa; Battiprolu, Pavan K.; Jiang, Nan; May, Herman I.; Morselli, Eugenia; Somlo, Stefan; Smedt, Humbert de; Gillette, Thomas G.; Lavandero González, Sergio; Hill, Joseph A. (Elsevier, 2018-05)
      Aims: Considerable evidence points to critical roles of intracellular Ca2+ homeostasis in the modulation and control of autophagic activity. Yet, underlying molecular mechanisms remain unknown. Mutations in the gene (pkd2) ...
    • Regulation of cardiomyocyte autophagy by calcium 

      Shaikh, Soni; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Bravo Sagua, Roberto; García Nannig, Lorena; Morselli, Eugenia; Cifuentes, Mariana; Quest, Andrew F. G.; Hill, Joseph A.; Lavandero González, Sergio (Amer Physiological Soc, 2016)
      Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion ...
    • Senescence, Apoptosis or Autophagy? 

      Vicencio, José Miguel; Galluzzi, Lorenzo; Tajeddine, Nicolás; Ortiz, Carla; Criollo Céspedes, Alfredo; Tasdemir, E.; Morselli, Eugenia; Ben Younes, Amena; Chiara Maiuri, María; Lavandero González, Sergio; Kroemer, Guido (S. Karger AG, 2008)
      Many features of aging result from the incapacity of cells to adapt to stress conditions. When damage accumulates irreversibly, mitotic cells from renewable tissues rely on either of two mechanisms to avoid replication. ...
    • Senescence, apoptosis or autophagy? When a damaged cell must decide its path - A mini-review 

      Vicencio, José Miguel; Galluzzi, Lorenzo; Tajeddine, Nicolas; Ortiz, Carla; Criollo Céspedes, Alfredo; Tasdemir, Ezgi; Morselli, Eugenia; Ben Younes, Amena; Maiuri, Maria Chiara; Lavandero González, Sergio; Kroemer, Guido (2008)
      Many features of aging result from the incapacity of cells to adapt to stress conditions. When damage accumulates irreversibly, mitotic cells from renewable tissues rely on either of two mechanisms to avoid replication. ...
    • Sex hormones and cardiometabolic health: Role of estrogen and estrogen receptors 

      Clegg, Deborah; Hevener, Andrea L.; Moreau, Kerrie L.; Morselli, Eugenia; Criollo Céspedes, Alfredo; Van Pelt, Rachael E.; Vieira Potter, Victoria J. (Oxford University Press, 2017-05)
      With increased life expectancy, women will spend over three decades of life postmenopause. The menopausal transition increases susceptibility to metabolic diseases such as obesity, diabetes, cardiovascular disease, and ...