Now showing items 1-20 of 24

    • Activity of metalloproteinase-9 is related to oxidative stress in the acute coronary syndrome 

      Bittner, Alex; Castro Agüero, Pablo; Pérez, Osvaldo; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo Andrés; Chiong Lay, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (OXFORD UNIV PRESS, 2006-08)
      Meeting Abstract
    • Atrial Function Assessed by Speckle Tracking Echocardiography Is a Good Predictor of Postoperative Atrial Fibrillation in Elderly Patients 

      Verdejo, Hugo E.; Becerra, Elia; Zalaquet, Ricardo; Campo, Andrea del; García Nannig, Lorena; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Marín, Arnaldo; Castro, Pablo F.; Lavandero González, Sergio; Gabrielli, Luigi A.; Corbalán, Ramón (Wiley & Sons, 2016)
      ObjectiveAdvanced age is an independent predictor of postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass surgery. We evaluated whether left atrial (LA) dysfunction assessed by strain ...
    • Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity 

      Pizarro, Marcela; Troncoso Cotal, Rodrigo; Martínez, Gonzalo J.; Chiong Lay, Mario; Castro, Pablo F.; Lavandero González, Sergio (Elsevier, 2016)
      Doxorubicin (Doxo) is one of the most effective anti-neoplastic agents but its cardiotoxicity has been an important clinical limitation. The major mechanism of Doxo-induced cardiotoxicity is associated to its oxidative ...
    • Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation 

      Aránguiz Urroz, Pablo Daniel; Canales Urriola, Jimena Andrea; Copaja, Miguel; Troncoso Cotal, Rodrigo Andrés; Vicencio Bustamante, José Miguel; Carrillo Ballesteros, Constanza Carolina; Lara Peñaloza, Hernán; Lavandero González, Sergio; Díaz Araya, Guillermo (ELSEVIER SCIENCE BV, 2011-01)
      Autophagy is a physiological degradative process key to cell survival during nutrient deprivation, cell differentiation and development. It plays a major role in the turnover of damaged macromolecules and organelles, and ...
    • Differential Participation of Angiotensin II Type 1 and 2 Receptors in the Regulation of Cardiac Cell Death Triggered by Angiotensin II 

      Aránguiz Urroz, Pablo Daniel; Soto Muñoz, Dagoberto; Contreras Ferrat, Ariel Eduardo; Troncoso Cotal, Rodrigo Andrés; Chiong Lay, Mario; Montenegro Obregón, José Joaquín; Venegas Pino, Daniel Esteban; Smolic Smolic, Christian; Ayala Jeria, Pedro Segundo; Thomas, W. G.; Lavandero González, Sergio; Díaz Araya, Guillermo (NATURE PUBLISHING GROUP, 2009-05)
      The Angiotensin II (Ang II) type 1 (AT(1)R) and type 2 (AT(2)R) receptors are increased in the heart following myocardial infarction and dilated cardiomyopathy, yet their contribution at a cellular level to compensation ...
    • Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury 

      Zepeda Iriarte, Ramiro; Kuzmicic, Jovan; Parra Ortiz, Valentina; Troncoso Cotal, Rodrigo; Pennanen, Christian; Riquelme, Jaime A.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Sánchez Vergara, Gina; Lavandero González, Sergio (Lippincott Williams and Wilkins, 2014)
      Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
    • Efectos del carvedilol en la capacidad funcional, función ventricular izquierda, catecolaminas y estrés oxidativo en pacientes con insuficiencia cardíaca crónica. 

      Castro, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso Cotal, Rodrigo Andrés; Padilla, Ivonne; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Lavandero González, Sergio (Sociedad Española de Cardiología, 2004)
      El carvedilol es un antagonista adrenérgico con acción antioxidante y un demostrado beneficio sobre la mortalidad en insuficiencia cardíaca (IC). El objetivo de este estudio es evaluar, en pacientes con insuficiencia ...
    • Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress in patients with chronic heart failure. Efectos del carvedilol en la capacidad funcional, función ventricular izquierda, catecolaminas y estrés oxidativo en pacientes con insuficiencia cardíaca crónica. 

      Castro Agüero, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Padilla, Ivonne; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Lavandero González, Sergio (EDICIONES DOYMA S/L, 2004-11)
      Introduction and objective. Carvedilol is an antioxidant and adrenergic antagonist with demonstrated benefits in terms of mortality from heart failure (HF). The aim of the present study was to evaluate clinical parameters, ...
    • Effects of Carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure 

      Castro, Pablo; Mac-Nab, P.; Quintana, Juan Pablo; Bittner, Alex; Greig, Douglas; Vergara, I.; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Copaja, Miguel; Díaz Araya, Guillermo; Chiong Lay, Mario; Troncoso Cotal, Rodrigo Andrés; Alcaíno Olivares, Hernán Alejandro; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2005-07-15)
      Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure (HF), determining left ventricular (LV) and interventricular contraction synchrony at baseline and after 6 ...
    • FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes 

      Oyarzún, Alejandra P.; Westermeier, Francisco; Pennanen, Christian; López Crisosto, Camila; Parra, Valentina; Sotomayor Flores, Cristian; Sánchez Vergara, Gina; Pedrozo Cibils, Zully; Troncoso Cotal, Rodrigo; Lavandero González, Sergio (Elsevier, 2015)
      Aim: FK866 is an inhibitor of the NAD(+) synthesis rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT). Using FK866 to target NAD(+) synthesis has been proposed as a treatment for inflammatory diseases and ...
    • Gln(27)-> Glu beta(2)-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and Oxidative Response to Carvedilol 

      Troncoso Cotal, Rodrigo Andrés; Moraga, Francisco; Chiong Lay, Mario; Roldán S., Juan; Bravo Méndez, Roberto; Valenzuela, Rodrigo; Díaz Araya, Guillermo; Campo Sfeir, Andrea Estefanía del; Sanhueza Muñoz, Carlos Joaquín; Rodríguez Villarroel, Andrea Elizabeth; Vukasovic Ramírez, José Luis; Mellado, Rose Marie; Greig, Douglas; Castro, Pablo; Lavandero González, Sergio (WILEY-BLACKWELL PUBLISHING, 2009-05)
      We investigated the clinical response of chronic heart failure patients with beta(2)- adrenergic receptor Gln(27)-> Glu polymorphism treated for 6 months with carvedilol, a alpha/beta-antagonist with antioxidant properties. ...
    • Glucocorticoid resistance in chronic diseases 

      Rodriguez, Juan; Monsalves Álvarez, Matías; Henriquez, Sandra; Llanos Silva, Miguel; Troncoso Cotal, Rodrigo (Elsevier Science, 2016-11)
      Glucocorticoids are involved in several responses triggered by a variety of environmental and physiological stimuli. These hormones have a wide-range of regulatory effects in organisms. Synthetic glucocorticoids are ...
    • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) 

      Klionsky, Daniel J.; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Glavic Maurer, Álvaro; Corbalán, Ramón; Matus, Soledad; Segura Aguilar, Juan; Hetz Flores, Claudio (Taylor & Francis inc., 2016)
    • Hyperosmotic stress stimulates autophagy via polycystin-2 

      Peña Oyarzún, Daniel; Troncoso Cotal, Rodrigo; Kretschmar, Catalina; Hernando, Cecilia; Budini, Mauricio; Morselli, Eugenia; Lavandero González, Sergio; Criollo Céspedes, Alfredo (Impact Journals, 2017)
      Various intracellular mechanisms are activated in response to stress, leading to adaptation or death. Autophagy, an intracellular process that promotes lysosomal degradation of proteins, is an adaptive response to several ...
    • IGF-1: Un factor de crecimiento con acciones cardiovasculares pleiotrópicas. 

      Contreras Ferrat, Ariel Eduardo; Aránguiz Urroz, Pablo Daniel; Díaz Elizondo, Jessica; Chiong Lay, Mario; Muñoz, Juan Pablo; Parra Ortíz, María Valentina; Ibarra, Cristián; Rojas Rivera, Diego; Troncoso Cotal, Rodrigo; Eisner, Verónica; Salas, Daniela; Rodríguez Villarroel, Andrea Elizabeth; Carrasco Alarcón, Loreto del Pilar; Díaz Araya, Guillermo; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2006)
      El factor de crecimiento análogo a insulina tipo 1 (IGF-1) es un péptido relacionado estructural y funcionalmente con insulina que posee efectos mitogénicos y citoprotectores. Sus efectos biológicos dependen de la activación ...
    • Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress (vol 124, pg 2143, 2011) 

      Bravo Méndez, Roberto; Vicencio Bustamante, José Miguel; Parra Ortíz, María Valentina; Troncoso Cotal, Rodrigo; Muñoz, Juan Pablo; Bui, Michael; Quiroga Lagos, Clara; Rodríguez Villarroel, Andrea Elizabeth; Verdejo, Hugo; Ferreira Parker, Jorge; Iglewski, Miriam; Chiong Lay, Mario; Simmen, Thomas; Zorzano, Antonio; Hill, Joseph A.; Rothermel, B. A.; Szabadkai, G.; Lavandero González, Sergio (COMPANY OF BIOLOGISTS LTD, 2011-07-15)
    • Irisin is weakly associated with usual physical activity in young overweight women 

      Tenorio, Beatriz; Jimenez, Teresa; Barrera Acevedo, María Gladys; Hirsch Birn, Sandra; Maza Cave, María Pía de la; Troncoso Cotal, Rodrigo; Farías, María Belén; Rodríguez, Juan Manuel; Bunout Barnett, Daniel (Aula medica ediciones, 2017)
      Purpose: To determine if irisin plasma levels are associated with regular physical activity, body composition and metabolic parameters in women subjected to calorie restriction. Subjects and methods: We studied 42 women ...
    • Mifepristone enhances insulin stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells 

      Bernal Sore, Izela; Navarro Márquez, Mario F.; Osorio Fuentealba, César; Díaz Castro, Francisco; Campo, Andrea del; Donoso Barraza, Camila; Porras Espinoza, Omar; Lavandero González, Sergio; Troncoso Cotal, Rodrigo (Elsevier, 2018)
      Mifepristone is the only FDA-approved drug for glycaemia control in patients with Cushing's syndrome and type 2 diabetes. Mifepristone also has beneficial effects in animal models of diabetes and patients with antipsychotic ...
    • Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake 

      Del Campo Sfeir, Andrea Estefanía; Parra Ortíz, María Valentina; Vásquez Trincado, César Alonso; Gutiérrez, Tomás; Morales, Pablo E.; López Crisosto, Camila; Bravo Sagua, Roberto; Navarro Márquez, Mario F.; Verdejo, Hugo E.; Contreras Ferrat, Ariel Eduardo; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Lavandero González, Sergio (American Physiological Society, 2014)
      Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural remodeling in order to cope with these ...
    • Organelle communication: Signaling crossroads between homeostasis and disease 

      Bravo Sagua, Roberto; Torrealba Cárdenas, Natalia Belén; Paredes, Felipe; Morales, Pablo E.; Pennanen Saavedra, Christian; López Crisosto, Camila; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Chiong Lay, Mario; Hill, Joseph A.; Simmend, Thomas; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2014)
      Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are ...