Now showing items 1-20 of 70

    • 1-benzoyl-2-(2-nitrophenyl)-1H-benzimidazole derivatives: A novel approach to the development of new HIV-1 reverse transcriptase inhibitors 

      Vásquez, David; Lagos González, Carlos F.; Mella Raipán, Jaime A.; González, Luis; Ebensperger González, Roberto; Alvarez Figueroa, M. Javiera; Sáez, Edmundo; Pessoa Mahana, Hernán; Araya Secchi, Raúl; González Wong, Angel; Pérez-Acle, Tomás; Pessoa, D. (SOC CHILENA QUIMICA, 2007-12)
      A novel approach to the development of anew class of HIV-1 RT inhibitors is reported. The 1-benzoyl-2-aryl-1H-benzimidazole series was designed as a combination of two previously reported active scaffolds, the benzimidazole ...
    • (2Z)-3-(5-hydroxy-4-oxo-4H-chromen-3-yl)acrylonitrile 

      Araya Maturana, Ramiro; Heredia Moya, Jorge; Pessoa Mahana, Hernán; Weiss López, Boris; Muñoz, J. C. (BLACKWELL MUNKSGAARD, 2005-04)
      The title compound, C12H7NO3, consists of a chromone moiety substituted in position 3 with an acrylonitrile group in a Z configuration. The two planar groups are twisted with respect to one another. The only significant ...
    • A Synthetic Overview of New Molecules with 5-HT1A Binding Affinities 

      Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa Mahana, Hernán; Pessoa, D. (Bentham Science Publishers, 2003)
      The present review discusses the synthetic strategies of new ligands exhibiting mainly 5-HT1A binding affinities. Specifically we focused our attention in the synthesis of compounds structurally related to arylpiperazine, ...
    • Access to quinazolines from 2-nitrobenzaldehyde and arylamines 

      Valderrama, Jaime A.; Pessoa Mahana, Hernán; Sarras, Gabriela; Tapia, Ricardo (1999)
      A synthesis of N-(2-nitrobenzyl)acetanilide (5) and (11) from 2- nitrobenzaldehyde and aromatic amines is reported. The reaction of amides (5) and (11) with iron in acetic acid-ethanol-water provided the corresponding 3- ...
    • Biological evaluation of novel 6-arylbenzimidazo [1,2-c]quinazoline derivatives as inhibitors of LPS-induced TNF-alpha secretion 

      Galarce, Gloria D.; Foncea, Rocío; Edwards, Ana María; Pessoa Mahana, Hernán; Pessoa Mahana, Carlos David; Ebensperger González, Roberto (SOC BIOLGIA CHILE, 2008)
      This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-alpha) production inhibitors. The newly synthesized compounds were tested for their in vitro ...
    • Conformational dynamics of substituted N-acetyl-N-phenylbenzylamines. 1H-DNMR and AM1-MO study 

      Weiss López, Boris; Saitz Barría, Claudio; Pessoa Mahana, Hernán; Valderrama, Jaime; Araya Maturana, Ramiro (2001)
      Activation parameters for the rotation around the methylene-nitrogen single bond found in a series of four 2,2'-disubstituted N-acetyl-N-phenylbenzylamines, dissolved in DMSO-d6, were measured employing the temperature ...
    • Conformational dynamics of substituted N-acetyl-N-phenylbenzylamines. H-1-DNMR and AM1-MO study 

      Weiss López, Boris; Jullian Matthaei, Carolina; Saitz Barría, Claudio; Pessoa Mahana, Hernán; Valderrama, J.; Araya Maturana, Ramiro (SOCIEDAD CHILENA DE QUIMICA, 2001-09)
      Activation parameters for the rotation around the methylene-nitrogen single bond found in a series of four 2,2'-disubstituted N-acetyl-N-phenylbenzylamines, dissolved in DMSO-d(6), were measured employing the temperature ...
    • Design, synthesis, binding and docking-based 3D-QSAR studies of 2-pyridylbenzimidazoles - A new family of high affinity CB1 cannabinoid ligands 

      Mella Raipán, Jaime A.; Lagos, Carlos F.; Recabarren Gajardo, Gonzalo Iván; Espinosa Bustos, Christian; Romero Parra, Javier; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Carlos David (2013)
      A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 ...
    • Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles-A New Family of High Affinity CB1 Cannabinoid Ligands 

      Mella Raipán, Jaime A.; Lagos, Carlos F.; Recabarren Gajardo, Gonzalo Iván; Espinosa Bustos, Christian; Romero Parra, Javier; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Carlos David (2013)
      A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 ...
    • Design, synthesis, biological evaluation and binding mode modeling of benzimidazole derivatives targeting the cannabinoid receptor type 1 

      Espinosa Bustos, Christian; Lagos, Carlos F.; Romero Parra, Javier; Zárate, Ana M.; Mella Raipán, Jaime A.; Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Iturriaga-Vásquez, Patricio; Tapia, Ricardo A.; Pessoa Mahana, Carlos David (Wiley-VCH Verlag, 2015)
      © 2015 Wiley-VCH Verlag GmbH & Co. KGaA. A series of N-acyl-2,5-dimethoxyphenyl-1H-benzimidazoles were designed based on a CoMFA model for cannabinoid receptor type 1 (CB1) ligands. Compounds were synthesized and radioligand ...
    • Determination and characterization of new benzimidazoles with activity against Trypanosoma cruzi by UV spectroscopy and HPLC 

      Brain Isasi, S.; Quezada Aburto, Cristián Salvador; Pessoa Mahana, Hernán; Morello Casté, Antonio; Kogan Bocian, Marcelo; Álvarez Lueje, Alejandro (PERGAMON-ELSEVIER SCIENCE LTD, 2008-08-15)
      This work presents the development of analytical methodologies by UV spectrophotometry and HPLC to characterize five nitroarylbenzimidazole derivatives with activity against Trypanosoma cruzi: NB, BNB, PNB, PMNB and PCNB. ...
    • Domino inverse electron demand Diels-Alder reactions of chromones with ethyl vinyl ether 

      Heredia Moya, Jorge; Krohn, Karsten; Florke, Ulrich; Pessoa Mahana, Hernán; Weiss López, Boris; Estévez, A.; Araya Maturana, Ramiro (PERGAMON-ELSEVIER SCIENCE LTD, 2007-06-01)
      E)-Ethyl 3-(4-oxo-4H-chromen-3-yi)acrylate (3), (E)-3-(4-oxo-4H-chromen-3-yl)-2-propenenitrile (12) and their 5-hydroxy-derivatives 11 and 13 undergo alternative, solvent dependent, domino reactions with ethyl vinyl ether. ...
    • Effects of 4,4-dimethyl-5,8-dihydroxynaphtalene-1-one and 4,4-dimethyl-5,8-dihydroxytetralone derivatives on tumor cell respiration 

      Araya Maturana, Ramiro; Delgado Castro, Tomás; Gárate, M.; Ferreira Parker, Jorge; Pavani, M.; Pessoa Mahana, Hernán; Cassels Niven, Bruce (PERGAMON-ELSEVIER SCIENCE LTD, 2002-09)
      A set of structurally related compounds incorporating a carbonyl group in the ortho position with regard to a phenol function were tested against the TA3 mouse carcinoma cell line and its multidrug-resistant variant ...
    • Effects of 4,4-Dimethyl-5,8-dihydroxynaphtalene-1-one and 4,4-Dimethyl-5,8-dihydroxytetralone Derivatives onTumor Cell Respiration 

      Araya Maturana, Ramiro; Delgado Castro, Tomás; Gárate, Mario; Ferreira Parker, Jorge; Pavani, Mario; Pessoa Mahana, Hernán; Cassels Niven, Bruce (Elsevier Science Ltd., 2002-01-29)
      Abstract—A set of structurally related compounds incorporating a carbonyl group in the ortho position withregard to a phenol function were tested against the TA3 mouse carcinoma cell line and its multidrug-resistant variant ...
    • Effects of 9,10-dihydroxy-4,4-dimethyl-5,8-dihydro-1(4H)- anthracenone derivatives on tumor cell respiration 

      Araya Maturana, Ramiro; Cardona, Wilson; Cassels Niven, Bruce; Delgado Castro, Tomás; Ferrada Parker, Jorge; Miranda, Dante; Pavani, Mario; Pessoa Mahana, Hernán; Soto Delgado, Jorge; Weiss López, Boris (Elsevier Ltd., 2006-02-28)
      A series of tricyclic hydroquinones, incorporating a carbonyl group in the ortho position relative to the phenol function, were tested as inhibitors of oxygen uptake against the TA3 mouse carcinoma cell line and its ...
    • Effects of 9,10-dihydroxy-4,4-dimethyl-5,8-dihydro-1(4H)-anthracenone derivatives on tumor cell respiration 

      Araya Maturana, Ramiro; Cardona, Wilson; Cassels Niven, Bruce; Delgado Castro, Tomás; Ferrada Parker, Jorge; Miranda, Dante; Pavani, Mario; Pessoa Mahana, Hernán; Soto Delgado, Jorge; Weiss López, Boris (Elsevier Ltd., 2006-02-28)
      Abstract—A series of tricyclic hydroquinones, incorporating a carbonyl group in the ortho position relative to the phenol function, were tested as inhibitors of oxygen uptake against the TA3 mouse carcinoma cell line and ...
    • Effects of 9,10-dihydroxy-4,4-dimethyl-5,8-dihydro-1(4H)-anthracenone derivatives on tumor cell respiration 

      Araya Maturana, Ramiro; Cardona, Wilson; Cassels Niven, Bruce; Delgado Castro, Tomás; Ferrada Parker, Jorge; Miranda, Dante; Pavani, Mario; Pessoa Mahana, Hernán; Soto Delgado, Jorge; Weiss López, Boris (PERGAMON-ELSEVIER SCIENCE LTD, 2006-07-01)
      A series of tricyclic hydroquinones, incorporating a carbonyl group in the ortho position relative to the phenol function, were tested as inhibitors of oxygen uptake against the TA3 mouse carcinoma cell line and its ...
    • Effects of simple and angular chromones on tumor cell respiration 

      Araya Maturana, Ramiro; Heredia Moya, Jorge; Donoso Tauda, Oscar; Vera Castillo, Mario Francisco; Toledo Hernández, Jorge; Pavani, Mario; Pessoa Mahana, Hernán; Weiss López, Boris; Ferreira Parker, Jorge (NATURAL PRODUCTS INC, 2008)
      A set of structurally related compounds incorporating a chromone moiety as an essential component of their structures were tested against the TA3 mouse carcinoma cell line and its multidrug-resistant variant TA3-MTX-R. A ...
    • Electrochemical reduction of 2,5-dimethoxy nitrobenzenes: nitro radical anion generation and biological activity 

      Álvarez Lueje, Alejandro; Pessoa Mahana, Hernán; Núñez Vergara, Luis; Squella Serrano, Juan (ELSEVIER SCIENCE, 1998-08)
      The electrochemical reduction of four 2,5-dimethoxy nitrobenzene 6-substituted derivatives in aqueous and mixed media by cyclic voltammetry, tast and differential pulse polarography were studied. In aqueous media, pH > 8, ...
    • Electrochemical study and analytical applications for new biologically active 2-nitrophenylbenzimidazole derivatives 

      Álvarez Lueje, Alejandro; Zapata Urzúa, Claudio Andrés; Brain Isasi, S.; Pérez Ortiz, María Magdalena; Barros, L.; Pessoa Mahana, Hernán; Kogan Bocian, Marcelo (ELSEVIER SCIENCE BV, 2009-08-15)
      The present study addresses the electrochemical behavior and the analytical applications of six 2-nitrophenylbenzimidazole derivatives with activity against Trypanosoma cruzi. When studied in a wide range of pH, by ...