Now showing items 1-16 of 16

    • Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro 

      Ocaranza, Maria Paz; Lavandero González, Sergio; Jalil Milad, Jorge; Moya, Jaqueline; Pinto, Melissa; Novoa, Ulises; Apablaza, Felipe; González, Leticia; Hernández, Carol; Varas, Manuel; López, René; Godoy, Iván; Verdejo, Hugo; Chiong Lay, Mario (Lippincott Williams and Wilkins, 2010)
      Background: Angiotensin-(1-9) is present in human and rat plasma and its circulating levels increased early after myocardial infarction or in animals treated with angiotensin-converting enzyme inhibitor. However, the ...
    • Changes in cyclic AMP dependent protein kinase and active stiffness in the rat volume overload model of heart hypertrophy 

      Lavandero González, Sergio; Cartagena, Gastón; Guarda, Eduardo; Corbalán, Ramón; Godoy, Iván; Sapag Hagar, Mario; Jalil Milad, Jorge (Oxford University Press, 1993)
      Objective: The aim was to clarify the role of cyclic AMP dependent protein kinase (PKA) and changes in mechanical heart function during development of cardiac hypertrophy induced by volume overload. Methods: Protein and ...
    • Cyclic AMP-dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction 

      Piddo Mijares, Ana María; Sánchez, María Isabel; Sapag Hagar, Mario; Corbalán, Ramón; Foncea, Rocío; Ebensperger González, Roberto; Godoy, Iván; Meléndez, Jaime; Jalil Milad, Jorge; Lavandero González, Sergio (Academic Press, 1996)
      The role of cyclic AMP-dependent protein kinase (PKA) and systolic function during the development of left ventricular hypertrophy (LVH) still remain uncertain. The aim of this work is to study PKA activity and mechanical ...
    • Effects of atorvastatin therapy in heart failure: Oxidative stress, inflammation, endothelial dysfunction and exercise capacity 

      Miranda, Rodrigo; Castro, Pablo; Verdejo, Hugo; Greig, Douglas; Alcaíno Olivares, Hernán Alejandro; Bustos Contreras, Carlos Andrés; Vukasovic Ramírez, José Luis; Godoy, Iván; Díaz Araya, Guillermo; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2007-03-06)
      Meeting Abstract
    • Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat 

      Ocaranza, María Paz; Godoy, Iván; Jalil Milad, Jorge; Varas, Manuel; Collantes, Patricia; Pinto, Melissa; Román, Maritza; Ramírez, Cristián; Copaja, Miguel; Díaz Araya, Guillermo; Castro, Pablo; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2006-10)
      The early and long-term effects of coronary artery ligation on the plasma and left ventricular angiotensin-converting enzyme (ACE and ACE2) activities, ACE and ACE2 mRNA levels, circulating angiotensin (Ang) levels [Ang ...
    • Increased Oxidative Stress Correlates With Pulmonary Vascular Response to Vasodilators in Pulmonary Artery Hypertension Patients 

      Castro Agüero, Pablo; Gabrielli, Luigi; Fasce, Fabrizio; Verdejo, Hugo; Greig, Douglas; Llevaneras, Silvana; Ferrada, Marcela; Hernández, Claudia; Godoy, Iván; García Nannig, Lorena; Mellado, Rose Marie; Sepúlveda, Pablo; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2009-03-10)
      Meeting Abstract
    • Increased rho-kinase activity in hypertensive patients with left ventricular hypertrophy 

      Gabrielli, Luigi A.; Winter, José L.; Godoy, Iván; McNab, Paul; Padilla, Ivonne; Córdova, Samuel; Rigotti, Paola; Novoa, Ulises; Mora, Italo; García Nannig, Lorena; Ocaranza, María P.; Jalil Milad, Jorge (Oxford University Press, 2014)
      background There is experimental evidence on the role of Rho-kinase (ROCK) activation in cardiac hypertrophy but no information on its role in human hypertension and left ventricular hypertrophy (LVH). We hypothesized that ...
    • Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica 

      Greig, Douglas; Castro, Pablo; Gabrielli, Luigi A.; Miranda, Rodrigo; Verdejo, Hugo; Alcaíno Gálvez, Hernán Alejandro; Bustos, Carlos; Chiong Lay, Mario; Godoy, Iván; Mellado, Rose Marie; García Nannig, Lorena; Salas, Daniela; Vivar Sánchez, Raúl; Vukasovic Ramírez, José Luis; Concepción, Roberto; Díaz Araya, Guillermo (SOC MEDICA SANTIAGO, 2008-06)
      Background: In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. ...
    • Inflammation and endothelial dysfunction in patients with chronic heart failure Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica 

      Greig, Douglas; Castro, Pablo; Gabrielli, Luigi; Miranda, Rodrigo; Verdejo, Hugo; Alcaíno Gálvez, Hernán Alejandro; Bustos, Carlos; Chiong Lay, Mario; Godoy, Iván; Mellado, Rosemarie; García Nannig, Lorena; Salas, Daniela; Vivar, Raúl; Vukasovic, José Luis; Concepción, Roberto; Díaz Araya, Guillermo (2008)
      Background: In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. ...
    • Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-1-converting enzyme deletion/deletion genotype 

      Jalil Milad, Jorge; Palomera Gómez, Cristián Alejandro; Ocaranza, María Paz; Godoy, Iván; Román, Maritza; Chiong Lay, Mario; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2003-09-15)
      In patients with hypertension who have the DD-ACE genotype (higher angiotensin-converting enzyme [ACE] activity), plasma levels of angiotensin-(1-7) are 4 times lower than in patients with the II-ACE genotype (lower ACE ...
    • Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure 

      Ocaranza, María Paz; Gabrielli, Luigi; Mora, Italo; García Nannig, Lorena; McNab, Paul; Godoy, Iván; Braun, Sandra; Córdova, Samuel; Castro, Pablo; Novoa, Ulises; Chiong Lay, Mario; Lavandero González, Sergio; Jalil, E. (MOSBY-ELSEVIER, 2011-05)
      Background The small guanosine triphosphatase Rho and its target Rho-kinase have significant roles in experimental remodeling and ventricular dysfunction, but no data are available on Rho-kinase activation in patients with ...
    • Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca 

      Castro, Pablo; Gabrielli, Luigi A.; Verdejo, Hugo; Greig, Douglas; Mellado, Rose Marie; Concepción, Roberto; Sepúlveda Morales, Luis; Vukasovic Ramírez, José Luis; García Nannig, Lorena; Pizarro, Marcela; Pivet, Deisy; Carrillo, Constanza; Tapia, Fabiola; Navarro, Mario; Troncoso, Rodrigo; Baraona, Fernando; Llevaneras, Silvana; Hernández, Claudia; Godoy, Iván; Jalil Milad, Jorge; Quintana, Juan Carlos; Orellana, Pilar; Chiong Lay, Mario; Lavandero González, Sergio (SOC MEDICA SANTIAGO, 2010-08)
      It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the ...
    • Pleiotropic effects of atorvastatin in heart failure: Role in oxidative stress, inflammation, endothelial function, and exercise capacity 

      Castro, P.; Miranda, Rodrigo; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Alcaíno Olivares, Hernán Alejandro; Chiong Lay, Mario; Bustos Contreras, Carlos Andrés; García Nannig, Lorena; Mellado, Rose Marie; Vukasovic Ramírez, José Luis; Godoy, Iván; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2008-04)
      Background: Increased oxidative stress, a common feature in chronic heart failure, has been associated with inflammation, endothelial dysfunction, and extracellular matrix degradation. Statins have known anti-inflammatory ...
    • Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2 

      Ocaranza, María Paz; Valderas, Patricio; Moya, Jackeline; Gabrielli, Luigi; Godoy, Iván; Córdava, Samuel; Mac Nab, Paul; García Nannig, Lorena; Farías, Luis; Jalil, Jorge E. (BMC, 2020)
      BackgroundThe intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity is increased. Besides, in preclinical models of diabetes, ...
    • Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure 

      Alcaíno Gálvez, Hernán Alejandro; Greig, Douglas; Chiong Lay, Mario; Verdejo, Hugo; Miranda, Rodrigo; Concepción, Roberto; Vukasovic Ramírez, José Luis; Díaz Araya, Guillermo; Mellado, Rose Marie; García Nannig, Lorena; Salas, Daniela; González, Leticia; Godoy, Iván; Castro, Pablo; Lavandero González, Sergio (ELSEVIER, 2008-07)
      Increased serum uric acid has been identified as an independent risk factor for cardiovascular disease. However, because of its antioxidant capacity, uric acid may play a beneficial role in endothelial function. This ...
    • Xanthine-oxidase inhibitors and statins in chronic heart failure: Effects on vascular and functional parameters 

      Greig, Douglas; Alcaíno Gálvez, Hernán Alejandro; Castro Gálvez, Pablo; García Nannig, Lorena; Verdejo, Hugo E.; Navarro, Mario; López, Rafael; Mellado, Rose Marie; Tapia Mamani, Fabiola Karina; Gabrielli, Luigi A.; Nogerol, Camilo; Chiong Lay, Mario; Godoy, Iván; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2011-04)
      Increased oxidative stress in heart failure (HF) leads to inflammation and endothelial dysfunction (ED). Both statins and allopurinol have known anti-oxidant properties, but their utility in HF has not been fully assessed.