Browsing by Author "37811f1c-81df-486f-a81b-4887f2266e96"

Now showing items 1-9 of 9

    • Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death 
      Sánchez, Gina; Berrios, Daniela; Olmedo, Ivonne; Pezoa, Javier; Riquelme, Jaime A.; Montecinos, Luis; Pedrozo Cibils, Zully; Donoso Laurent, Paulina (Public Library Science, 2016)
      Inhibitors of the ubiquitin-proteasome system improve hemodynamic parameters and decrease the infarct size after ischemia reperfusion. The molecular basis of this protection is not fully understood since most available ...
    • Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and ... 
      Vivar, Raúl; Humeres, Claudio; Varela, Marcelo; Ayala, Pedro; Guzmán, Nancy; Olmedo, Ivonne; Catalán, Mabel; Boza Fuentes, Pía; Muñoz, Claudia; Díaz Araya, Guillermo (2012)
      Cardiac fibroblast (CF) death by ischemia/reperfusion (I/R) has major implications for cardiac wound healing. Although IGF-1 has well-known cytoprotective effects, no study has been done on CF subjected to simulated ...
    • Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast 
      Catalán, Mabel; Smolic, Christian; Contreras, Ariel; Ayala, Pedro; Olmedo, Ivonne; Copaja, Miguel; Boza Fuentes, Pía; Vivar, Raúl; Avalos, Yennifer; Lavandero González, Sergio; Velarde, Victoria; Díaz Araya, Guillermo (2012)
      Kinins mediate their cellular effects through B1 (B1R) and B2 (B2R) receptors, and the activation of B2R reduces collagen synthesis in cardiac fibroblasts (CF). However, the question of whether B1R and/or B2R have a role ...
    • Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AK ... 
      Córdova, Andrés; Olmedo, Ivonne; Riquelme, J.; Barrientos, G.; Sánchez, G.; Gillette, Thomas G.; Lavandero González, Sergio; Chiong Lay, Mario; Donoso, P.; Pedrozo Cibils, Zully (Elsevier Science BV, 2018)
      The L-type calcium channel (LTCC) is an important determinant of cardiac contractility. Therefore, changes in LTCC activity or protein levels could be expected to affect cardiac function. Several studies describing LTCC ...
    • Multifunctionalized gold nanoparticles with peptides targeted to gastrin-releasing peptide receptor of a ... 
      Hosta-Rigau, Leticia; Olmedo, Ivonne; Arbiol, Jordi; Cruz, Luis J.; Kogan Bocian, Marcelo; Albericio, Fernando (2010)
      Functionalization of gold nanoparticles (AuNPs) with both a targeting peptide (an analogue of the peptide Bombesin) and a drug peptide ligand (an analogue of the RAF peptide) with the aim of improving selectivity in the ...
    • Ni/Ni oxides nanoparticles with potential biomedical applications obtained by displacement of a ... 
      Rodríguez Llamazares, Saddys; Merchán, Juan; Olmedo, Ivonne; Marambio, Héctor; Muñoz, Juan; Jara, Paul; Sturm, Juan; Chornik, Boris; Peña, Octavio; Yutronic Sáez, Nicolás; Kogan Bocian, Marcelo (2008)
      A new synthesis and stabilization method was developed for paramagnetic nanoparticles composed of nickel and nickel oxides. Nickel/nickel oxides nanoparticles were synthesized by a method based on ligand displacement of ...
    • Peptides and metallic nanoparticles for biomedical applications 
      Kogan Bocian, Marcelo; Olmedo, Ivonne; Hosta, Leticia; Guerrero, Ariel; Cruz, Luis; Albericio, Fernando (2007)
      In this review, we describe the contribution of peptides to the biomedical applications of metallic nanoparticles. We also discuss strategies for the preparation of peptide-nanoparticle conjugates and the synthesis of the ...
    • Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts 
      Copaja, Miguel; Venegas, Daniel; Aránguiz, Pablo; Canales, Jimena; Vivar, Raúl; Catalán, Mabel; Olmedo, Ivonne; Rodríguez, Andrea E.; Chiong Lay, Mario; Leyton Campos, Lisette; Lavandero González, Sergio; Díaz Araya, Guillermo (2011)
      Several clinical trials have shown the beneficial effects of statins in the prevention of coronary heart disease. Additionally, statins promote apoptosis in vascular smooth muscle cells, in renal tubular epithelial cells ...
    • TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both ... 
      Vivar, Raúl; Humeres, Claudio; Ayala, Pedro; Olmedo, Ivonne; Catalán, Mabel; García Nannig, Lorena; Lavandero González, Sergio; Díaz Araya, Guillermo (2013)
      Ischemia/reperfusion injury is a major cause of myocardial death. In the heart, cardiac fibroblasts play a critical role in healing post myocardial infarction. TGF-β1 has shown cardioprotective effects in cardiac damage; ...