Now showing items 1-20 of 20

    • ACE2 and vasoactive peptides: Novel players in cardiovascular/renal remodeling and hypertension 

      Mendoza Torres, Evelyn; Oyarzún, Alejandra; Mondaca Ruff, David; Azocar, Andrés; Chiong Lay, Mario; Castro, Pablo F.; Jalil Milad, Jorge; Lavandero González, Sergio; Ocaranza, María Paz (2015)
      The renin–angiotensin system (RAS) is a key component of cardiovascular physiology and homeostasis due to its influence on the regulation of electrolyte balance, blood pressure, vascular tone and cardiovascular remodeling. ...
    • Acute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with pulmonary artery hypertension 

      Gabrielli, Luigi; Ocaranza, María Paz; Sitges, Marta; Kanacri, Andrés; Saavedra, Rodrigo; Sepúlveda, Pablo; Sepúlveda, Luis; Rossel, Víctor; Zagolin, Mónica; Verdejo, Hugo E.; Baraona, Fernando; Zalaquett, Ricardo; Chiong, Mario; Lavandero González, Sergio; Castro, Pablo F. (Blackwell, 2017)
      Background: Right atrium function and ventricular function have significant prognos-tic value in pulmonary arterial hypertension patients. Acute changes in right ventricu-lar synchrony and right atrium function postiloprost ...
    • Atrial Function Assessed by Speckle Tracking Echocardiography Is a Good Predictor of Postoperative Atrial Fibrillation in Elderly Patients 

      Verdejo, Hugo E.; Becerra, Elia; Zalaquet, Ricardo; Campo, Andrea del; García Nannig, Lorena; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Marín, Arnaldo; Castro, Pablo F.; Lavandero González, Sergio; Gabrielli, Luigi A.; Corbalán, Ramón (Wiley & Sons, 2016)
      ObjectiveAdvanced age is an independent predictor of postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass surgery. We evaluated whether left atrial (LA) dysfunction assessed by strain ...
    • Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity 

      Pizarro, Marcela; Troncoso Cotal, Rodrigo; Martínez, Gonzalo J.; Chiong Lay, Mario; Castro, Pablo F.; Lavandero González, Sergio (Elsevier, 2016)
      Doxorubicin (Doxo) is one of the most effective anti-neoplastic agents but its cardiotoxicity has been an important clinical limitation. The major mechanism of Doxo-induced cardiotoxicity is associated to its oxidative ...
    • Cardiotoxicidad inducida por tratamientos oncológicos. Fundamentos para la implementación de equipos de cardio-oncología 

      Hameau, Rene; Gabrielli, Luigi; Garrido, Marcelo; Guzmán, Ana M.; Retamal, Ignacio; Vacarezza, María José; Greig, Douglas; Ocqueteau, Mauricio; Sanchez, Cesar; Pizarro, Marcela; Corvalan, Alejandro; Lavandero González, Sergio; Castro, Pablo F.; Martinez, Gonzalo (Sociedad Médica de Santiago, 2018-01)
      Recently, we have witnessed major improvements in cancer treatment. Early diagnosis and development of new therapies have reduced cancer-related mortality. However, these new therapies, along with greater patient survival, ...
    • Cardiotoxicity of anticancer therapies. Towards the implementation of cardio-oncology units Cardiotoxicidad inducida por tratamientos oncológicos. Fundamentos para la implementación de equipos de Cardio-Oncología 

      Hameau, Rene; Gabrielli, Luigi; Garrido, Marcelo; Guzmán, Ana María; Retamal, Ignacio; Vacarezza, María José; Greig, Douglas; Ocqueteau, Mauricio; Sánchez, César; Pizarro, Marcela; Corvalán, Alejandro; Lavandero González, Sergio; Castro, Pablo F.; Martínez, Gonzalo (Sociedad Medica de Santiago, 2018)
      © 2018, Sociedad Medica de Santiago. All rights reserved. Recently, we have witnessed major improvements in cancer treatment. Early diagnosis and development of new therapies have reduced cancer-related mortality. However, ...
    • Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy 

      Westermeier, Francisco; Navarro Márquez, Mario F.; López Crisosto, Camila; Bravo Sagua, Roberto; Quiroga Lagos, Clara; Bustamante, Mario; Verdejo, Hugo E.; Zalaquett, Ricardo; Ibacache, Mauricio; Parra Ortíz, María Valentina; Castro, Pablo F.; Rothermel, Beverly A.; Hill, Joseph A.; Lavandero González, Sergio (Elsevier, 2015)
      Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes mellitus (T2DM) and encompasses structural, morphological, functional, and metabolic abnormalities in the heart.Myocardial energy metabolism ...
    • Effects of Trimetazidine in Nonischemic Heart Failure: A Randomized Study 

      Winter, José Luis; Castro, Pablo F.; Quintana, Juan Carlos; Altamirano, Rodrigo; Enriquez, Andrés; Verdejo, Hugo E.; Jalil Milad, Jorge; Mellado, Rose Marie; Concepción, Roberto; Sepúlveda, Pablo; Rossel Mariangel, Víctor Alejandro; Sepúlveda Morales, Luis; Chiong Lay, Mario; García Nannig, Lorena; Lavandero González, Sergio (Elsevier, 2014)
      Objectives: Heart failure (HF) is associated with changes in myocardial metabolism that lead to impairment of contractile function. Trimetazidine (TMZ) modulates cardiac energetic efficiency and improves outcomes in ...
    • ER-to-mitochondria miscommunication and metabolic diseases 

      López Crisosto, Camila; Bravo Sagua, Roberto; Rodríguez Peña, Marcelo; Mera, Claudia; Castro, Pablo F.; Quest, Andrew F. G.; Rothermel, Beverly A.; Cifuentes, Mariana; Lavandero González, Sergio (Elsevier, 2015)
      © 2015 Elsevier B.V.. Eukaryotic cells contain a variety of subcellular organelles, each of which performs unique tasks. Thus follows that in order to coordinate these different intracellular functions, a highly dynamic ...
    • Gln27→Gluβ2-adrenergic receptor polymorphism in heart failure patients: Differential clinical and oxidative response to carvedilol 

      Troncoso, Rodrigo; Moraga, Francisco; Chiong Lay, Mario; Roldán, Juan; Bravo, Roberto; Valenzuela, Rodrigo; Díaz Araya, Guillermo; Del Campo, Andrea; Sanhueza, Carlos; Rodriguez, Andrea; Vukasovic, José Luis; Mellado, Rosemarie; Greig, Douglas; Castro, Pablo F.; Lavandero González, Sergio (2009)
      We investigated the clinical response of chronic heart failure patients with β2-adrenergic receptor Gln27→Glu polymorphism treated for 6 months with carvedilol, a α/β-antagonist with antioxidant properties. The 6-min. walk ...
    • Increased active phase atrial contraction is related to marathon runner performance 

      Gabrielli, Luigi; Herrera, Sebastián; Contreras Briceño, Felipe; Vega, Julián; Ocaranza, María Paz; Yáñez, Fernando; Fernández, Rodrigo; Saavedra, Rodrigo; Sitges, Marta; García, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Castro, Pablo F. (Springer Verlag, 2018)
      © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Left atrial (LA) contraction is essential for left ventricular (LV) filling during exertion. We sought to evaluate the relationship of LA contraction ...
    • Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells 

      Parra Ortíz, María Valentina; Bravo Sagua, Roberto; Norambuena Soto, Ignacio; Hernández Fuentes, Carolina; Gómez Contreras, Andrés; Verdejo, Hugo E.; Mellado, Rosemarie; Chiong Lay, Mario; Lavandero González, Sergio; Castro, Pablo F. (Elsevier, 2017)
      Chronic hypoxia exacerbates proliferation of pulmonary arterial smooth muscle cells (PASMC), thereby reducing the lumen of pulmonary arteries. This leads to poor blood oxygenation and cardiac work overload, which are the ...
    • Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome 

      Bittner, Alex; Alcaíno Gálvez, Hernán Alejandro; Castro, Pablo F.; Pérez, Osvaldo; Corbalán, Ramón; Troncoso, Rodrigo; Chiong Lay, Mario; Mellado, Rosemarie; Moraga, Francisco; Zanolli, Diego; Winter, José L.; Zamorano, Juan J.; Díaz Araya, Guillermo; Lavandero González, Sergio (2010)
    • Mitochondria, myocardial remodeling, and cardiovascular disease 

      Verdejo, Hugo E.; Del Campo, Andrea; Troncoso, Rodrigo; Gutiérrez, Tomás; Toro, Barbra; Quiroga, Clara; Pedrozo Cibils, Zully; Muñoz, Juan Pablo; García, Lorena; Castro, Pablo F.; Lavandero González, Sergio (2012)
      The process of muscle remodeling lies at the core ofmost cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
    • Mitochondrial dynamics: A potential new therapeutic target for heart failure Dinámica mitocondrial: un potencial nuevo blanco terapéutico para la insuficiencia cardiaca 

      Kuzmicic, Jovan; Del Campo, Andrea; López Crisosto, Camila; Morales, Pablo E.; Pennanen, Christian; Bravo Sagua, Roberto; Hechenleitner, Jonathan; Zepeda, Ramiro; Castro, Pablo F.; Verdejo, Hugo E.; Parra, Valentina; Chiong Lay, Mario; Lavandero González, Sergio (2011)
      Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. ...
    • Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: Evolution toward prospective theranostic approaches 

      Bejarano, Julian; Navarro Márquez, Mario F.; Morales Zavala, Francisco; Morales, Javier O.; García Carvajal, Ivonne; Araya Fuentes, Eyleen; Flores, Yvo; Verdejo, Hugo E.; Castro, Pablo F.; Lavandero González, Sergio; Kogan Bocian, Marcelo (Ivyspring International Publisher, 2018)
      © Ivyspring International Publisher. Cardiovascular diseases are the leading cause of death worldwide. Despite preventive efforts, early detection of atherosclerosis, the common pathophysiological mechanism underlying ...
    • New Molecular Insights of Insulin in Diabetic Cardiomyopathy 

      Westermeier, Francisco; Riquelme, Jaime A.; Pavez, Mario; Garrido, Valeria; Díaz, Ariel; Verdejo, Hugo E.; Castro, Pablo F.; García Nannig, Lorena; Lavandero González, Sergio (Frontiers Media S.A., 2016-04)
      Type 2 diabetes mellitus (T2DM) is a highly prevalent disease worldwide. Cardiovascular disorders generated as a consequence of T2DM are a major cause of death related to this disease. Diabetic cardiomyopathy (DCM) is ...
    • Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024 

      Ferreccio, Catterina; Roa, Juan Carlos; Bambs, Claudia; Vives, Alejandra; Corvalán, Alejandro H.; Cortés, Sandra; Foerster, Claudia; Acevedo, Johanna; Huidobro, Andrea; Passi, Alvaro; Toro, Pablo; Covacevich, Yerko; Cruz, Rolando de la; Koshiol, Jill; Olivares, Mauricio; Miquel, Juan Francisco; Cruz, Francisco; Silva, Raúl; Quest, Andrew F. G.; Kogan Bocian, Marcelo; Castro, Pablo F.; Lavandero González, Sergio (BioMed Central, 2016)
      Background: Maule Cohort (MAUCO), a Chilean cohort study, seeks to analyze the natural history of chronic diseases in the agricultural county of Molina (40,000 inhabitants) in the Maule Region, Chile. Molina's population ...
    • Systemic oxidative stress and endothelial dysfunction is associated with an attenuated acute vascular response to inhaled prostanoid in pulmonary artery hypertension patients 

      Gabrielli, Luigi A.; Castro, Pablo F.; Godoy, Ivan; Mellado, Rosemarie; Bourge, Robert C.; Alcaíno Gálvez, Hernán Alejandro; Chiong Lay, Mario; Greig, Douglas; Verdejo, Hugo E.; Navarro, Mario; Lopez, Rafael; Toro, Barbra; Quiroga, Clara; Díaz Araya, Guillermo; Lavandero González, Sergio; Garcia, Lo (2011)
      Background: Systemic endothelial dysfunction and increased oxidative stress have been observed in pulmonary arterial hypertension (PAH). We evaluate whether oxidative stress and endothelial dysfunction are associated with ...
    • Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes 

      Kuzmicic Previtali, Jovan Paolo; Parra, Valentina; Verdejo, Hugo E.; López Crisosto, Camila; Chiong Lay, Mario; García, Lorena; Jensen, Michael D.; Bernlohr, David A.; Castro, Pablo F.; Lavandero González, Sergio (Elsevier Inc., 2014)
      © 2014 Elsevier Inc. All rights reserved. Metabolic and cardiovascular disease patients have increased plasma levels of lipids and, specifically, of palmitate, which can be toxic for several tissues. Trimetazidine (TMZ), ...