Now showing items 1-20 of 20

    • A new role for HERPUD1 and ERAD activation in osteoblast differentiation and mineralization 

      Américo-Da-Silva, Luan; Diaz, Jheimmy; Bustamante, Mario; Mancilla, Georthan; Oyarzún, Ingrid; Verdejo, Hugo E.; Quiroga, Clara (FASEB, 2018)
      © FASEB. Bone integrity depends on a finely tuned balance between bone synthesis by osteoblasts and resorption by osteoclasts. The secretion capacity of mature osteoblasts requires strict control of proteostasis. Endoplasmic ...
    • Acute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with pulmonary artery hypertension 

      Gabrielli, Luigi; Ocaranza, María Paz; Sitges, Marta; Kanacri, Andrés; Saavedra, Rodrigo; Sepúlveda, Pablo; Sepúlveda, Luis; Rossel, Víctor; Zagolin, Mónica; Verdejo, Hugo E.; Baraona, Fernando; Zalaquett, Ricardo; Chiong Lay, Mario; Lavandero González, Sergio; Castro, Pablo F. (Blackwell, 2017)
      Background: Right atrium function and ventricular function have significant prognos-tic value in pulmonary arterial hypertension patients. Acute changes in right ventricu-lar synchrony and right atrium function postiloprost ...
    • Atrial Function Assessed by Speckle Tracking Echocardiography Is a Good Predictor of Postoperative Atrial Fibrillation in Elderly Patients 

      Verdejo, Hugo E.; Becerra, Elia; Zalaquet, Ricardo; Campo, Andrea del; García Nannig, Lorena; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Marín, Arnaldo; Castro, Pablo F.; Lavandero González, Sergio; Gabrielli, Luigi A.; Corbalán, Ramón (Wiley & Sons, 2016)
      ObjectiveAdvanced age is an independent predictor of postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass surgery. We evaluated whether left atrial (LA) dysfunction assessed by strain ...
    • Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy 

      Westermeier, Francisco; Navarro Márquez, Mario F.; López Crisosto, Camila; Bravo Sagua, Roberto; Quiroga Lagos, Clara; Bustamante, Mario; Verdejo, Hugo E.; Zalaquett, Ricardo; Ibacache, Mauricio; Parra Ortíz, María Valentina; Castro, Pablo F.; Rothermel, Beverly A.; Hill, Joseph A.; Lavandero González, Sergio (Elsevier, 2015)
      Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes mellitus (T2DM) and encompasses structural, morphological, functional, and metabolic abnormalities in the heart.Myocardial energy metabolism ...
    • Effects of Trimetazidine in Nonischemic Heart Failure: A Randomized Study 

      Winter, José Luis; Castro, Pablo F.; Quintana, Juan Carlos; Altamirano, Rodrigo; Enriquez, Andrés; Verdejo, Hugo E.; Jalil Milad, Jorge; Mellado, Rose Marie; Concepción, Roberto; Sepúlveda, Pablo; Rossel Mariangel, Víctor Alejandro; Sepúlveda Morales, Luis; Chiong Lay, Mario; García Nannig, Lorena; Lavandero González, Sergio (Elsevier, 2014)
      Objectives: Heart failure (HF) is associated with changes in myocardial metabolism that lead to impairment of contractile function. Trimetazidine (TMZ) modulates cardiac energetic efficiency and improves outcomes in ...
    • Impaired cardiac autophagy in patients developing postoperative atrial fibrillation 

      García Nannig, Lorena; Verdejo, Hugo E.; Kuzmicic, Jovan; Zalaquett, Ricardo; Gonzalez, Sergio; Lavandero González, Sergio; Corbalan, Ramon (Mosby Inc., 2012)
      Objectives: Postoperative atrial fibrillation (POAF) is a common complication after on-pump heart surgery. Several histologic abnormalities, such as interstitial fibrosis and vacuolization, have been described in atrial ...
    • Increased C-reactive protein plasma levels are not involved in the onset of post-operative atrial fibrillation 

      Campo, Andrea del; Roldán, Juan; Verdejo, Hugo E.; Zalaquett, Ricardo; Becerra, Elia; Navarro Márquez, Mario; Mellado, Rosemarie; Lavandero González, Sergio; Corbalán, Ramón; García Nannig, Lorena; Chiong Lay, Mario (Elsevier, 2017)
      Background: Increased inflammation biomarkers plasma levels, including C-reactive protein (CRP), have been associated with the initiation and perpetuation of atrial fibrillation (AF). However, it is not known whether an ...
    • Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress 

      Bravo Méndez, Roberto; Vicencio Bustamante, José Miguel; Parra Ortíz, María Valentina; Troncoso, Rodrigo; Muñoz, Juan Pablo; Bui, Michael; Quiroga Lagos, Clara; Rodríguez Villarroel, Andrea Elizabeth; Verdejo, Hugo E.; Ferreira Parker, Jorge; Iglewski, Miriam; Chiong Lay, Mario; Simmen, Thomas; Zorzano, Antonio; Hill, Joseph A.; Rothermel, B. A.; Szabadkai, Gyorgy; Lavandero González, Sergio (COMPANY OF BIOLOGISTS LTD., 2011-07-15)
      Increasing evidence indicates that endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR), but that beyond a certain degree of ER damage, this response triggers apoptotic pathways. The ...
    • Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells 

      Parra Ortíz, María Valentina; Bravo Sagua, Roberto; Norambuena Soto, Ignacio; Hernández Fuentes, Carolina; Gómez Contreras, Andrés; Verdejo, Hugo E.; Mellado, Rosemarie; Chiong Lay, Mario; Lavandero González, Sergio; Castro, Pablo F. (Elsevier, 2017)
      Chronic hypoxia exacerbates proliferation of pulmonary arterial smooth muscle cells (PASMC), thereby reducing the lumen of pulmonary arteries. This leads to poor blood oxygenation and cardiac work overload, which are the ...
    • Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the AktmTOR-NFkB-Opa-1 signaling pathway 

      Parra, Valentina; Verdejo, Hugo E.; Iglewski, Myriam; Del Campo, Andrea; Troncoso, Rodrigo; Jones, Deborah; Zhu, Yi; Kuzmicic Previtali, Jovan Paolo; Pennanen, Christian; López Crisosto, Camila; Jaña, Fabián; Ferreira, Jorge; Noguera, Eduard; Chiong Lay, Mario; Bernlohr, David A.; Klip, Amira (2014)
      Insulin regulates heart metabolism through the regulation of insulin-stimulated glucose uptake. Studies have indicated that insulin can also regulate mitochondrial function. Relevant to this idea, mitochondrial function ...
    • Label-Free Graphene Oxide-Based Surface Plasmon Resonance Immunosensor for the Quantification of Galectin-3, a Novel Cardiac Biomarker 

      Primo, Emiliano N.; Kogan Bocian, Marcelo; Verdejo, Hugo E.; Bollo Dragnic, Soledad; Rubianes, María D.; Rivas, Gustavo A. (American Chemical Society, 2018)
      © 2018 American Chemical Society. We report the first optical biosensor for the novel and important cardiac biomarker, galectin-3 (Gal3), using the anti-Gal3 antibody as a biorecognition element and surface plasmon resonance ...
    • Mitochondria, myocardial remodeling, and cardiovascular disease 

      Verdejo, Hugo E.; Del Campo, Andrea; Troncoso, Rodrigo; Gutiérrez, Tomás; Toro, Barbra; Quiroga, Clara; Pedrozo Cibils, Zully; Muñoz, Juan Pablo; García, Lorena; Castro, Pablo F.; Lavandero González, Sergio (2012)
      The process of muscle remodeling lies at the core ofmost cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
    • Mitochondrial dynamics: A potential new therapeutic target for heart failure Dinámica mitocondrial: un potencial nuevo blanco terapéutico para la insuficiencia cardiaca 

      Kuzmicic, Jovan; Del Campo, Andrea; López Crisosto, Camila; Morales, Pablo E.; Pennanen, Christian; Bravo Sagua, Roberto; Hechenleitner, Jonathan; Zepeda, Ramiro; Castro, Pablo F.; Verdejo, Hugo E.; Parra, Valentina; Chiong Lay, Mario; Lavandero González, Sergio (2011)
      Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. ...
    • Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake 

      Del Campo Sfeir, Andrea Estefanía; Parra Ortíz, María Valentina; Vásquez Trincado, César Alonso; Gutiérrez, Tomás; Morales, Pablo E.; López Crisosto, Camila; Bravo Sagua, Roberto; Navarro Márquez, Mario F.; Verdejo, Hugo E.; Contreras Ferrat, Ariel Eduardo; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Lavandero González, Sergio (American Physiological Society, 2014)
      Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural remodeling in order to cope with these ...
    • Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake 

      Del Campo, Andrea; Parra, Valentina; Vásquez Trincado, César Alonso; Gutiérrez, Tomás; Morales, Pablo E.; López Crisosto, Camila; Bravo Sagua, Roberto; Navarro Márquez, Mario F.; Verdejo, Hugo E.; Contreras Ferrat, Ariel Eduardo; Troncoso, Rodrigo; Chiong Lay, Mario; Lavandero González, Sergio (2014)
      Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural remodeling in order to cope with these ...
    • Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: Evolution toward prospective theranostic approaches 

      Bejarano, Julian; Navarro Márquez, Mario F.; Morales Zavala, Francisco; Morales, Javier O.; García Carvajal, Ivonne; Araya Fuentes, Eyleen; Flores, Yvo; Verdejo, Hugo E.; Castro, Pablo F.; Lavandero González, Sergio; Kogan Bocian, Marcelo (Ivyspring International Publisher, 2018)
      © Ivyspring International Publisher. Cardiovascular diseases are the leading cause of death worldwide. Despite preventive efforts, early detection of atherosclerosis, the common pathophysiological mechanism underlying ...
    • New Molecular Insights of Insulin in Diabetic Cardiomyopathy 

      Westermeier, Francisco; Riquelme, Jaime A.; Pavez, Mario; Garrido, Valeria; Díaz, Ariel; Verdejo, Hugo E.; Castro, Pablo F.; García Nannig, Lorena; Lavandero González, Sergio (Frontiers Media S.A., 2016-04)
      Type 2 diabetes mellitus (T2DM) is a highly prevalent disease worldwide. Cardiovascular disorders generated as a consequence of T2DM are a major cause of death related to this disease. Diabetic cardiomyopathy (DCM) is ...
    • Systemic oxidative stress and endothelial dysfunction is associated with an attenuated acute vascular response to inhaled prostanoid in pulmonary artery hypertension patients 

      Gabrielli, Luigi A.; Castro, Pablo F.; Godoy, Ivan; Mellado, Rosemarie; Bourge, Robert C.; Alcaíno Gálvez, Hernán Alejandro; Chiong Lay, Mario; Greig, Douglas; Verdejo, Hugo E.; Navarro, Mario; Lopez, Rafael; Toro, Barbra; Quiroga, Clara; Díaz Araya, Guillermo; Lavandero González, Sergio; Garcia, Lo (2011)
      Background: Systemic endothelial dysfunction and increased oxidative stress have been observed in pulmonary arterial hypertension (PAH). We evaluate whether oxidative stress and endothelial dysfunction are associated with ...
    • Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes 

      Kuzmicic Previtali, Jovan Paolo; Parra, Valentina; Verdejo, Hugo E.; López Crisosto, Camila; Chiong Lay, Mario; García, Lorena; Jensen, Michael D.; Bernlohr, David A.; Castro, Pablo F.; Lavandero González, Sergio (Elsevier Inc., 2014)
      © 2014 Elsevier Inc. All rights reserved. Metabolic and cardiovascular disease patients have increased plasma levels of lipids and, specifically, of palmitate, which can be toxic for several tissues. Trimetazidine (TMZ), ...
    • Xanthine-oxidase inhibitors and statins in chronic heart failure: Effects on vascular and functional parameters 

      Greig, Douglas; Alcaíno Gálvez, Hernán Alejandro; Castro Gálvez, Pablo; García Nannig, Lorena; Verdejo, Hugo E.; Navarro, Mario; López, Rafael; Mellado, Rose Marie; Tapia Mamani, Fabiola Karina; Gabrielli, Luigi A.; Nogerol, Camilo; Chiong Lay, Mario; Godoy, Iván; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2011-04)
      Increased oxidative stress in heart failure (HF) leads to inflammation and endothelial dysfunction (ED). Both statins and allopurinol have known anti-oxidant properties, but their utility in HF has not been fully assessed.