Now showing items 1-10 of 10

    • Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes 

      Ávalos, Ana María; Arthur, William T.; Schneider, Pascal; Quest, Andrew F. G.; Burridge, Keith; Leyton Campos, Lisette (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2004-09-10)
      Thy-1, a cell adhesion molecule abundantly expressed in mammalian neurons, binds to a beta(3)-containing integrin on astrocytes and thereby stimulates the assembly of focal adhesions and stress fibers. Such events lead to ...
    • alpha (V) beta (3) Integrin regulates astrocyte reactivity 

      Lagos Cabre, Raúl; Álvarez, Álvaro; Kong, Milene; Burgos Bravo, Francesca; Cárdenas, Areli; Rojas Mancilla, Edgardo; Pérez Núñez, Ramón; Herrera Molina, Rodrigo; Rojas, Fabiola; Schneider, Pascal; Herrera-Marschitz Muller, Mario; Quest, Andrew F. G.; van Zundert, Brigitte; Leyton Campos, Lisette (BIOMED Central Ltd., 2017)
      Background: Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging alpha(V)beta(3) Integrin and Syndecan-4. Primary astrocytes express ...
    • alpha(V)beta(3) Integrin regulates astrocyte reactivity 

      Lagos Cabre, Raúl; Álvarez Martínez, Alvaro; Kong Rojas, Milene; Burgos Bravo, Francesca; Cárdenas Oyarzo, Areli; Rojas Mancilla, Edgardo; Pérez Núñez, Ramón; Herrera Molina, Rodrigo; Rojas, Fabiola; Schneider, Pascal; Herrera Marschitz, Mario; Quest, Andrew F. G.; van Zundert, Brigitte; Leyton Campos, Lisette (BMC, 2017)
      Background: Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging alpha(V)beta(3) Integrin and Syndecan-4. Primary astrocytes express ...
    • Astrocytic α vβ 3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering thy-1 

      Herrera Molina, Rodrigo; Frischknecht, Renato; Maldonado, Horacio; Seidenbecher, Constanze I.; Gundelfinger, Eckart D.; Hetz Flores, Claudio; Aylwin Ostale, María de la Luz; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (2012)
      Thy-1 is a membrane glycoprotein suggested to stabilize or inhibit growth of neuronal processes. However, its precise function has remained obscure, because its endogenous ligand is unknown. We previously showed that Thy-1 ...
    • ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation 

      Henríquez, Mauricio; Herrera Molina, Rodrigo; Valdivia, Alejandra; Alvarez, Alvaro; Kong, Milene; Muñoz, Nicolás; Eisner, Verónica; Jaimovich Pérez, Enrique; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (2011)
      Thy-1, an abundant mammalian glycoprotein, interacts with avβ3 integrin and syndecan-4 in astrocytes and thus triggers signaling events that involve RhoA and its effector p160ROCK, thereby increasing astrocyte adhesion to ...
    • Direct Thy-1/alpha(V)beta(3) integrin interaction mediates neuron to astrocyte communication 

      Hermosilla, Tamara; Muñoz, Daniel; Herrera Molina, Rodrigo; Valdivia, Alejandra; Muñoz, Nicolás; Nham, Sang-Uk; Schneider, Pascal; Burridge, Keith; Quest, Andrew F. G.; Leyton Campos, Lisette (ELSEVIER, 2008-06)
      Thy-1 is an abundant neuronal glycoprotein of poorly defined function. We recently provided evidence indicating that Thy-1 clusters a beta(3)-containing integrin in astrocytes to induce tyrosine phosphorylation, RhoA ...
    • Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration 

      Álvarez, Álvaro; Lagos Cabré, Raúl; Kong, Milene; Cárdenas, Areli; Burgos Bravo, Francesca; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (Elsevier, 2016)
      Our previous reports indicate that ligand-induced alpha(v)beta(3) integrin and Syndecan-4 engagement increases focal adhesion formation and migration of astrocytes. Additionally, ligated integrins trigger ATP release through ...
    • Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with αvβ3 integrin that activates PKCα and RhoA 

      Avalos, Ana María; Valdivia, Alejandra D.; Muñoz, Nicolás; Herrera Molina, Rodrigo; Tapia, Julio C.; Lavandero González, Sergio; Chiong Lay, Mario; Burridge, Keith; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (2009)
      Clustering of αvβ3 integrin after interaction with the RGD-like integrin-binding sequence present in neuronal Thy-1 triggers formation of focal adhesions and stress fibers in astrocytes via RhoA activation. A putative ...
    • Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4 

      Kong, Milene; Muñoz, Nicolás; Valdivia, Alejandra; Alvarez, Alvaro; Herrera Molina, Rodrigo; Cárdenas, Areli; Schneider, Pascal; Burridge, Keith; Quest, Andrew F. G.; Leyton Campos, Lisette (2013)
      Cell adhesion to the extracellular matrix proteins occurs through interactions with integrins that bind to Arg-Gly-Asp (RGD) tripeptides, and syndecan-4, which recognizes the heparin-binding domain of other proteins. Both ...
    • Thy-1-mediated cell–cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4 

      Kong, Milene; Muñoz, Nicolás; Valdivia, Alejandra; Álvarez, Ávaro; Herrera Molina, Rodrigo; Cárdenas, Areli; Schneider, Pascal; Burridge, Keith; Quest, Andrew F. G.; Leyton Campos, Lisette (Elsevier, 2013)
      Cell adhesion to the extracellular matrix proteins occurs through interactions with integrins that bind to Arg-Gly-Asp (RGD) tripeptides, and syndecan-4, which recognizes the heparin-binding domain of other proteins. ...