Now showing items 1-4 of 4

    • Miranda, Melissa; Fuenzalida, Karen; Rosen, Clifford J.; Seitz, Germán; Rodríguez, J. Pablo (Wiley-Blackwell, 2016)
      Bone marrow adipose tissue (BMAT) is associated with low bone mass, although the functional consequences for skeletal maintenance of increased BMAT are currently unclear. BMAT might have a role in systemic energy metabolism, ...
    • Xian, Lingling; Wu, Xiangwei; Pang, Lijuan; Lou, Michael; Rosen, Clifford J.; Qiu, Tao; Crane, Janet; Frassica, Frank; Zhang, Liming; Rodriguez, Juan Pablo; Jia, Xiaofeng; Yakar, Shoshana; Xuan, Shouhong; Efstratiadis, Argiris; Wan, Mei; Cao, Xu (2012)
      Insulin-like growth factor 1 (IGF-1), the most abundant growth factor in the bone matrix, maintains bone mass in adulthood. We now report that IGF-1 released from the bone matrix during bone remodeling stimulates osteoblastic ...
    • Román, Flavia; Urra, Carla; Porras Espinoza, Omar; Pino, Ana María; Rosen, Clifford J.; Rodríguez, Juan Pablo (Wiley-Liss Inc., 2017)
      © 2016 Wiley Periodicals, Inc. Oxidative stress (OS) derived from an increase in intracellular reactive oxygen species (ROS) is a major determinant of aging and lifespan. It has also been associated with several age-related ...
    • Li, Xiaojuan; Shet, Keerthi; Xu, Kaipin; Rodríguez, Juan; Pino, Ana María; Kurhanewicz, John; Schwartz, Ann; Rosen, Clifford (Elsevier Inc., 2017)
      There are increasing evidences suggesting bone marrow adiposity tissue (MAT) plays a critical role in affecting both bone quantity and quality. However, very limited studies that have investigated the association between the ...