Browsing by Author "XX600826"
Now showing items 1-20 of 79
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Activation of RANKL-induced osteoclasts and memory T lymphocytes by Porphyromonas gingivalis is serotype dependant
Vernal Astudillo, Rolando; Díaz Zúñiga, Jaime; Melgar Rodríguez, Samanta; Pujol, Myriam; Díaz Guerra, Eva; Silva, Augusto; Sanz, Mariano; García Sanz, José (Blackwell Munksgaard, 2014)Aim: Destructive periodontitis is associated with a Th1–Th17 immune response and activation of RANKL-induced osteoclasts. In addition, Porphyromonas gingivalis K1 and K2 serotypes induce a strong Th1–Th17 response. This ... -
Aggregatibacter actinomycetemcomitans Induces Autophagy in Human Junctional Epithelium Keratinocytes
Vicencio, Emiliano; Cordero, Esteban M.; Cortés, Bastián I.; Palominos, Sebastián; Parra, Pedro; Mella, Tania; Henrríquez, Constanza; Salazar, Nelda; Monasterio Ocares, Gustavo; Cafferata, Emilio A.; Murgas, Paola; Vernal Astudillo, Rolando; Cortez, Cristian (MDPI, 2020)The adverse environmental conditions found in the periodontium during periodontitis pathogenesis stimulate local autophagy responses, mainly due to a continuous inflammatory response against the dysbiotic subgingival ... -
Asociación de mayores niveles de RANKL y linfocitos T CD4+ en periodontitis
Vernal Astudillo, Rolando; Chaparro, Alejandra; Dutzan Muñoz, Nicolás; Chandía Espinosa, Sabrita; Puente Piccardo, Javier; Silva, Augusto; Gamonal Aravena, Jorge Antonio (Escuela de Odontología. Facultad de Salud. Universidad del Valle, 2004)Propósito: La periodontitis es una enfermedad infecciosa que involucra una sobre-respuesta inmune del hospedero y se caracteriza por la destrucción de los tejidos de soporte del diente.Durante su desarrollo se establece ... -
ATP Induces IL-1 β Secretion in Neisseria gonorrhoeae-Infected Human Macrophages by a Mechanism Not Related to the NLRP3/ASC/Caspase-1 Axis
Garciá, Killen; Escobar, Gisselle; Mendoza, Pablo; Beltran, Caroll; Pérez, Claudio; Arancibia, Sergio; Vernal Astudillo, Rolando; Rodas, Paula; Acunã-Castillo, Claudio; Escobar, Alejandro (Hindawi Limited, 2016)Neisseria gonorrhoeae (Ngo) has developed multiple immune evasion mechanisms involving the innate and adaptive immune responses. Recent findings have reported that Ngo reduces the IL-1𝛽 secretion of infected human ... -
ATP stimulated P2X7R enhances IL-1 beta secretion during Neisseria gonorrhoeae infection through a NLRP-3 inflammasome independent pathway
García, K.; Ortiz, C.; Escobar, G.; Mendoza, P.; Beltrán Muñoz, Caroll; Vernal Astudillo, Rolando; Escobar Álvarez, Alejandro Felipe (2016) -
Biochemical markers of bone metabolism in gingival crevicular fluid during early orthodontic tooth movement
Barbieri, German; Solano, Patricia; Alarcón, José Antonio; Vernal Astudillo, Rolando; Rios Lugo, Judith; Sanz, Mariano; Martín, Conchita (The EH Angle Education and Research Foundation, 2013)Objective: To evaluate the expression of an activator of nuclear factor-kappa (RANK), osteoprotegerin (OPG), osteopontin (OPN), and transforming growth factor ß1 (TGF-ß1) in gingival crevicular fluid (GCF) of teeth ... -
Bone resorptive activity in symptomatic and asymptomatic apical lesions of endodontic origin
Salinas Muñoz, M.; Garrido Flores, Carlos; Baeza Paredes, Mauricio; Huaman Chipana, P.; García Sesnich, Jocelyn; Bologna, R.; Vernal Astudillo, Rolando; Hernández, M. (Springer, 2017)The aim of this study is to assess the levels and diagnostic accuracy of a set of bone resorption biomarkers, including TRAP-5, RANKL, and OPG in symptomatic and asymptomatic apical lesions and controls. Apical tissues ... -
Brucella canis induces canine CD4 + T cells multi-cytokine Th1/Th17 production via dendritic cell activation
Pujol, Myriam; Borie Polanco, Consuelo; Montoya, María; Ferreira, Arturo; Vernal Astudillo, Rolando (Elsevier, 2019)Brucella canis is a small intracellular Gram-negative bacterium that frequently leads to chronic infections highly resistant to antibiotic therapy in dogs. Also, it causes mild human brucellosis compared to other zoonotic ... -
Capsular-defective Porphyromonas gingivalis mutant strains induce less alveolar bone resorption than W50 wild-type strain due to a decreased Th1/Th17 immune response and less osteoclast activity
Monasterio, Gustavo; Fernández, Baltasar; Castillo, Francisca; Rojas, Carolina; Cafferata, Emilio A.; Rojas, Leticia; Alvarez, Carla; Fernández, Alejandra; Hernández, Marcela; Bravo, Denisse; Vernal Astudillo, Rolando (Wiley-Blackwell, 2019)Background: Encapsulation of Porphyromonas gingivalis has been demonstrated as responsible of several host immunological changes, which have been associated with the pathogenesis of periodontitis. Using a murine model of ... -
CCL2 Inhibits the Apoptosis Program Induced by Growth Factor Deprivation, Rescuing Functional T Cells
Díaz Guerra, Eva; Vernal Astudillo, Rolando; Prete, M. Julieta del; Silva, Augusto; García Sanz, José A. (American Association of Immunologists, 2007)The precise mechanisms involved in the switch between the clonal expansion and contraction phases of a CD8 T cell response remain to be fully elucidated. One of the mechanisms implicated in the contraction phase is ... -
CCR7 in periodontal lymphoid-like structures formation
Álvarez Rivas, C.; Rojas, L.; Monasterio, G.; García, K.; Pujol, M.; Carvajal, P.; Vernal Astudillo, Rolando (2016) -
Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells
Silva Steffens, Nora; Dutzan Muñoz, Nicolás; Hernández Ríos, Emma; Dezerega Piwonka, Andrea; Rivera Escobar, Oriana; Aguillón Gutiérrez, Juan Carlos; Aravena, Octavio; Lastres, Pedro; Pozo, Patricia; Vernal Astudillo, Rolando; Gamonal Aravena, Jorge Antonio (Blackwell, 2008)Background and aims: Periodontitis is an infection with an episodic nature of tissue support destruction. The aim of this work was to determine the levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal ... -
Development of a self report questionnaire designed for population based surveillance of gingivitis in adolescents: assessment of content validity and reliability
Quiróz, Viviana; Reinero Núñez, Daniela; Hernández Ríos, Patricia; Contreras Balbontín, Johanna; Vernal Astudillo, Rolando; Carvajal, Paola (Universidade de São Paulo, 2017)The major infectious diseases in Chile encompass the periodontal diseases, with a combined prevalence that rises up to 90% of the population. Thus, the population-based surveillance of periodontal diseases plays a central ... -
Development of a self-report questionnaire designed for populationbased surveillance of gingivitis in adolescents: Assessment of content validity and reliability
Quiroz, Viviana; Reinero, Daniela; Hernández, Patricia; Contreras, Johanna; Vernal Astudillo, Rolando; Carvajal, Paola (Faculdade de Odontologia de Bauru, 2017)The major infectious diseases in Chile encompass the periodontal diseases, with a combined prevalence that rises up to 90% of the population. Thus, the population-based surveillance of periodontal diseases plays a central ... -
Differential cytokine expression by human dendritic cells in response to different Porphyromonas gingivalis capsular serotypes
Vernal Astudillo, Rolando; León, Rubén; Silva, Augusto; Van Winkelhoff, Arie; García Sanz, José; Sanz, Mariano (2009)Aim: Capsular polysaccharides play an important role in the virulence of Grampositive and Gram-negative bacteria. In Porphyromonas gingivalis, six serotypes have been described based on capsular antigenicity and its ... -
Differential expression of CC chemokines (CCLs) and receptors (CCRs) by human T lymphocytes in response to different Aggregatibacter actinomycetemcomitans serotypes
Alvarez, Carla; Benítez, Alvaro; Rojas, Leticia; Pujol, Myriam; Carvajal Pavez, Paola; Díaz Zúñiga, Jaime; Vernal Astudillo, Rolando (Univ. Sao Paulo, 2015)In Aggregatibacter actinomycetemcomitans, different serotypes have been described based on LPS antigenicity. Recently, our research group has reported a differential immunogenicity when T lymphocytes were stimulated with ... -
Differential expression of CC chemokines (CCLs) and receptors (CCRs) by human T lymphocytes in response to different Aggregatibacter actinomycetemcomitans serotypes
Alvarez Rivas, Carla; Benítez Cravero, Alvaro; Rojas, Leticia; Pujol, Myriam; Carvajal Pavez, Paola; Díaz Zúñiga, Jaime; Vernal Astudillo, Rolando (Univ Sao Paulo Fac Odontologia Bauru, 2015)In Aggregatibacter actinomycetemcomitans, different serotypes have been described based on LPS antigenicity. Recently, our research group has reported a differential immunogenicity when T lymphocytes were stimulated with ... -
Differential human Th22-lymphocyte response triggered by Aggregatibacter actinomycetemcomitans serotypes
Díaz Zúñiga, Jaime; Melgar Rodríguez, Samanta; Monasterio, Gustavo; Pujol, Myriam; Rojas, Leticia; Alvarez, Carla; Carvajal, Paola; Vernal Astudillo, Rolando (Elsevier Ltd, 2017)Objective: In Aggregatibacter actinomycetemcomitans, different serotypes have been described based on lipopolysaccharide (LPS) antigenicity. When T lymphocytes were stimulated with these serotypes, different patterns of ... -
Differential response of dendritic cells upon co-infection with different Aggregatibacter actinomycetemcomitans serotypes
Rojas, L.; Álvarez, C.; Melgar Rodríguez, Samanta Azucena; Pujol, M.; Monasterio, G.; García, K.; Díaz Zúñiga, J.; Fariña, V.; Hernández, M.; Vernal Astudillo, Rolando (2016) -
Distinct human T-lymphocyte responses triggered by Porphyromonas gingivalis capsular serotypes
Vernal Astudillo, Rolando; Diaz Guerra, Eva; Silva, Augusto; Sanz, Mariano; García Sanz, José A. (John Wiley & Sons, 2014)Aim: Porphyromonas gingivalis can synthesize an extracellular capsule and different serotypes have been described based on capsular antigenicity. On dendritic cells (DCs), the type of capsule present plays a role on the ...