Now showing items 1-20 of 29

    • Adrenergic and vasopressinergic contributions to the cardiovascular response to acute hypoxaemia in the llama fetus 

      Giussani, Dino A.; Riquelme González, Raquel; Sanhueza, E. M.; Hanson, M. A.; Blanco, C. E.; Llanos Mansilla, Jorge (CAMBRIDGE UNIV PRESS, 1999-02-15)
      1. The effects of ft tal intravenous treatment with phentolamine or a vasopressinergic V-1-receptor antagonist on the fetal cardiovascular responses to acute hypoxaemia in the llama were investigated. 2. Six llama fetuses ...
    • Advances in Fetal and Neonatal Physiology 

      Giussani, Dino A.; Niu, Youguo; Herrera Videla, Emilio; Richter, Hans G.; Camm, Emily J.; Thakor, Avnesh S.; Kane, Andrew D.; Hansell, Jeremy A.; Brain, Kirsty L.; Skeffington, Katie L.; Itani, Nozomi; Wooding, F. B. Peter; Cross, Christine M.; Allison, Beth J. (Springer, 2014)
      The quality of the intrauterine environment interacts with our genetic makeup to shape the risk of developing disease in later life. Fetal chronic hypoxia is a common complication of pregnancy. This chapter reviews how ...
    • Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano 

      Herrera Videla, Emilio; Reyes, Roberto V.; Giussani, Dino A.; Riquelme González, Raquel; Sanhueza Reinoso, Emilia; Ebensperger Darrouy, Germán; Casanello, Paola; Méndez, Natalia; Ebensperger, Renato; Sepúlveda Kattan, Esteban; Pulgar, Víctor M.; Cabello, Gertrudis; Blanco, Carlos E.; Hanson, Mark A.; Parer, Julian T.; Llanos Mansilla, Jorge (European Society of Cardiology, 2008)
      Aims To study the nitric oxide (NO) and carbon monoxide roles in the regulation of the pulmonary circulation in lowland and highland newborn sheep and llamas. Methods and results We used neonatal sheep (Ovis aries) and ...
    • Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano 

      Herrera Videla, Emilio; Rojas, Rodrigo T.; Krause, Bernardo J.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Giussani, Dino A.; Parer, Julian T.; Llanos Mansilla, Jorge (WILEY-BLACKWELL, 2016)
      High-altitude hypoxia causes intrauterine growth restriction and cardiovascular programming. However, adult humans and animals that have evolved at altitude show certain protection against the effects of chronic hypoxia. ...
    • Chemoreflex and endocrine components of cardiovascular responses to acute hypoxemia in the llama fetus 

      Giussani, Dino A.; Riquelme, Raquel A.; Moraga, Fernando A.; McGarrigle, Hugh H.G.; Gaete, Cristián R.; Sanhueza, Emilia M.; Hanson, Mark A.; Llanos Mansilla, Jorge (1996)
      We tested the hypothesis that the llama fetus has a blunted cardiovascular chemoreflex response to hypoxemia by investigating the effects of acute hypoxemia on perfusion pressure, heart rate, and the distribution of the ...
    • Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress 

      Giussani, Dino A.; Camm, Emily J.; Niu, Youguo; Richter, Hans G.; Blanco, Carlos E.; Gottschalk, Rachel; Blake, E. Zachary; Horder, Katy A.; Thakor, Avnesh S.; Hansell, Jeremy A.; Kane, Andrew D.; Wooding, F. B.Peter; Cross, Christine M.; Herrera, Emilio A. (2012)
      Fetal hypoxia is a common complication of pregnancy. It has been shown to programme cardiac and endothelial dysfunction in the offspring in adult life. However, the mechanisms via which this occurs remain elusive, precluding ...
    • Evolving in thin air-Lessons from the llama fetus in the altiplano 

      Llanos Mansilla, Jorge; Riquelme, Raquel A.; Herrera, Emilio A.; Ebensperger Darrouy, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza, Emilia M.; Pulgar, Víctor M.; Behn, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the low fetal arterial PO2 of all species, but also the likely ...
    • Evolving in thin air—Lessons from the llama fetus in the altiplano 

      Llanos Mansilla, Jorge; Riquelme González, Raquel; Herrera Videla, Emilio; Ebensperger Darrouy, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza Reinoso, Emilia; Pulgar, Víctor M.; Behn Thiele, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (ELSEVIER, 2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the lowfetal arterial PO2 of all species, but also the likely ...
    • Fetal and postnatal pulmonary circulation in the Alto Andino 

      Llanos Mansilla, Jorge; Ebensperger Darrouy, Germán; Herrera Videla, Emilio; Reyes, R. V.; Pulgar, V. M.; Serón Ferré, María; Díaz Beneventi, Mauricio; Parer, J. T.; Giussani, Dino A.; Moraga, F. A.; Riquelme González, Raquel (Elsevier, 2011)
      Lowland mammals at high altitude constrict the pulmonary vessels, augmenting vascular resistance and developing pulmonary arterial hypertension. In contrast, highland mammals, like the llama, do not present pulmonary ...
    • High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep 

      Herrera Videla, Emilio; Pulgar, Víctor M.; Riquelme González, Raquel; Sanhueza Reinoso, Emilia; Reyes, Roberto V.; Ebensperger Darrouy, Germán; Parer, Julian T.; Valdéz, Enrique A.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A.; Llanos Mansilla, Jorge (AMER PHYSIOLOGICAL SOC, 2007-06)
      Perinatal exposure to chronic hypoxia induces sustained pulmonary hypertension and structural and functional changes in both pulmonary and systemic vascular beds. The aim of this study was to analyze consequences of ...
    • Impaired Nitric Oxide Mediated Vasodilation in the Peripheral Circulation in the R6/2 Mouse Model of Huntington's Disease 

      Kane, Andrew D.; Niu, Youguo; Herrera, Emilio A.; Morton, A. Jennifer; Giussani, Dino A. (Nature Publishing Group, 2016)
      © 2016, Nature Publishing Group. All rights reserved. Recent evidence shows that the Huntington's disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular ...
    • Impaired Nitric Oxide Mediated Vasodilation In The Peripheral Circulation In The R6/2 Mouse Model Of Huntington's Disease 

      Kane, Andrew D.; Niu, Youguo; Herrera Videla, Emilio; Morton, A. Jennifer; Giussani, Dino A. (Nature, 2016)
      Recent evidence shows that the Huntington's disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular pathology pre-dates neurological decline, however ...
    • Induction of controlled hypoxic pregnancy in large mammalian species 

      Brain, Kirsty L.; Allison, Beth J.; Niu, Youguo; Cross, Christine M.; Itani, Nozomi; Kane, Andrew D.; Herrera, Emilio A.; Giussani, Dino A. (American Physiological Society, 2015)
      © 2015 The Authors. Progress in the study of pregnancy complicated by chronic hypoxia in large mammals has been held back by the inability to measure long-term significant reductions in fetal oxygenation at values similar ...
    • Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level 

      Herrera, Emilio A.; Riquelme, Raquel A.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Ulloa, César E.; Cabello, Gertrudis; Krause, Bernardo J.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (2010)
      We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms operating under these ...
    • Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant maturation in male fetuses in late gestation 

      McGillick, Erin V.; Orgeig, Sandra; Allison, Beth J.; Brain, Kirsty L.; Niu, Youguo; Itani, Nozomi; Skeffington, Katie L.; Kane, Andrew D.; Herrera Videla, Emilio; Giussani, Dino A.; Morrison, Janna L. (Wiley, 2017)
      Chronic fetal hypoxaemia is a common pregnancy complication that may arise from maternal, placental and/or fetal factors. Respiratory outcome of the infant at birth likely depends on the duration, timing and severity of ...
    • Maternal-to-fetal allopurinol transfer and xanthine oxidase suppression in the late gestation pregnant rat 

      Kane, Andrew D.; Camm, Emily J.; Richter, Hans G.; Lusby, Ciara; Tijsseling, Deodata; Kaandorp, Joepe J.; Derks, Jan B.; Ozanne, Susan E.; Giussani, Dino A. (American Physiological Society, 2013)
      © 2013 The Authors. Fetal brain hypoxic injury remains a concern in high-risk delivery. There is significant clinical interest in agents that may diminish neuronal damage during birth asphyxia, such as in allopurinol, an ...
    • Melatonin and vitamin C increase umbilical blood flow via nitric oxide-dependent mechanisms 

      Thakor, Avnesh S.; Herrera, Emilio A.; Serón Ferré, María; Giussani, Dino A. (2010)
      Inadequate umbilical blood flow leads to intrauterine growth restriction, a major killer in perinatal medicine today. Nitric oxide (NO) is important in the maintenance of umbilical blood flow, and antioxidants increase NO ...
    • Melatonin modulates the fetal cardiovascular defense response to acute hypoxia 

      Thakor, Avnesh S.; Allison, Beth J.; Niu, Youguo; Botting, Kimberley J.; Serón Ferré, María; Herrera Videla, Emilio; Giussani, Dino A. (Wiley & Sons, 2015)
      Experimental studies in animal models supporting protective effects on the fetus of melatonin in adverse pregnancy have prompted clinical trials in human pregnancy complicated by fetal growth restriction. However, the ...
    • Nitric oxide plays a role in the regulation of adrenal blood flow and adrenocorticomedullary functions in the llama fetus 

      Sánchez, G.; Liberona, Leonel; Llanos Mansilla, Jorge; Sanhueza, E. M.; Giussani, Dino A.; Blanco, C. E.; Hanson, M. A.; Riquelme González, Raquel (CAMBRIDGE UNIV PRESS, 2002-10-01)
      The hypothesis that nitric oxide plays a key role in the regulation of adrenal blood flow and plasma concentrations of cortisol and catecholamines under basal and hypoxaemic conditions in the llama fetus was tested. At ...
    • Reduced Cystathionine g-Lyase and Increased miR-21 Expression Are Associated with Increased Vascular Resistance in Growth-Restricted Pregnancies Hydrogen Sulfide as a Placental Vasodilator 

      Cindrova Davies, Tereza; Herrera Videla, Emilio; Niu, Youguo; Kingdom, John; Giussani, Dino A.; Burton, Graham J. (Elsevier, 2013)
      Increased vascular impedance in the fetoplacental circulation is associated with fetal hypoxia and growth restriction. We sought to investigate the role of hydrogen sulfide (H2S) in regulating vasomotor tone in ...