Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level
MetadataShow full item record
We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms operating under these circumstances. Pregnant ewes were divided into two groups: conception, pregnancy, and delivery at low altitude (580 m, LLL) and conception at low altitude, pregnancy at HA (3,600 m) from 30% of gestation until delivery, and return to lowland (LHL). Pulmonary arterial pressure (PAP) was measured in vivo. Vascular reactivity and morphometry were assessed in small pulmonary arteries (SPA). Protein expression of vascular mediators was determined. LHL lambs had higher basal PAP and a greater increment in PAP after NG-nitro-L- arginine methyl ester (20.9 ± 1.1 vs. 13.7 ± 0.5 mmHg; 39.9 ± 5.0 vs. 18.3 ± 1.3 mmHg, respectively). SPA from LHL had a greater maximal contraction to K+ (1.34 ± 0.05 vs. 1.16 ± 0.05 N/m), higher sensitivity to endothelin-1 and nitroprusside, and per
Artículo de publicación SCOPUS
Quote ItemAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology, Volumen 299, Issue 6, 2018,
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile
Showing items related by title, author, creator and subject.
2-Aminoethyldiphenylborinate modiﬁes the pulmonary circulation in pulmonary hypertensive newborn lambs partially gestated at high altitude Castillo Galán, Sebastián; Quezada, S.; Moraga, F.; Ebensperger Darrouy, Germán; Herrera, E. A.; Beñaldo, F.; Hernández, I.; Ebensperger, R.; Ramírez, S.; Llanos Mansilla, Jorge; Reyes, R. V. (Amer Physiological Soc., 2016-10)Calcium signaling through store-operated channels (SOC) is involved in hypoxic pulmonary hypertension. We determined whether a treatment with 2-aminoethyldiphenylborinate (2-APB), a compound with SOC blocker activity, ...
Chromosome 22q11 deletion in a patient with pulmonary atresia, intact ventricular septum, and confluent branch pulmonary arteries Aggarwal, Varun; Imamura, Michaki; Acuña Aguirre, Carlos; Cabrera, Antonio G. (Cambridge University Press, 2018)In this study, we report a patient with pulmonary atresia with intact ventricular septum (PA/IVS), confluent pulmonary arteries supplied by an arterial duct, and chromosome 22q11.2 microdeletion. The 22q11.2 deletion ...
Melatonin decreases pulmonary vascular remodeling and oxygen sensitivity in pulmonary hypertensive newborn lambs Astorga, Cristian R.; González Candia, Alejandro; Figueroa, Esteban G.; Cañas, Daniel; Ebensperger Darrouy, Germán; Reyes Catalán, Víctor; Llanos Mansilla, Jorge; Herrera Videla, Emilio; Candia, Alejandro A. (Frontiers media SA, 2018)Background: Chronic hypoxia and oxidative stress during gestation lead to pulmonary hypertension of the neonate (PHN), a condition characterized by abnormal pulmonary arterial reactivity and remodeling. Melatonin has strong ...