Recent Submissions

  • Proceso constituyente Chile 2020: lectura fácil 

    Besoaín Saldaña, Álvaro; Lezana Zúñiga, Melissa; Quinteros Pino, Richard (Universidad de Chile. Núcleo de Desarrollo Inclusivo, 2020)
    Contiene información sobre el plebiscito del 25 de octubre del 2020 en Chile. Fue elaborado pensado en personas que requieren apoyo en la comprensión lectora.
  • Comment on Melatonin as a potential adjuvant treatment for COVID-19 

    Herrera Videla, Emilio; González Candia, Alejandro (Elsevier, 2020)
  • Collateral Sprouting of Peripheral Sensory Neurons Exhibits a Unique Transcriptomic Profile 

    Lemaitre, Dominique; Llavero Hurtado, Maica; De Gregorio, Cristian; Oñate, Maritza G.; Martínez Bravo, Gabriela; Catenaccio, Alejandra; Wishart, Thomas M.; Court, Felipe A. (Springer, 2020)
    Peripheral nerve injuries result in motor and sensory dysfunction which can be recovered by compensatory or regenerative processes. In situations where axonal regeneration of injured neurons is hampered, compensation by ...
  • Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca2+ transfer for survival 

    Cárdenas, César; Lovy, Alenka; Silva Pavéz, Eduardo; Urra Faúndez, Félix; Mizzoni, Craig; Ahumada Castro, Ulises; Bustos, Galdo; Jaña, Fabián; Cruz, Pablo; Farías, Paula; Mendoza, Elizabeth; Huerta, Hernán; Murgas, Paola; Hunter, Martín; Ríos, Melany; Cerda Arancibia, Oscar; Georgakoudi, Irene; Zakarian, Armen; Molgó, Jordi; Foskett, James Kevin (AAAS. American Association for the Advancement of Science, 2020)
    Spontaneous Ca2+ signaling from the InsP(3)R intracellular Ca2+ release channel to mitochondria is essential for optimal oxidative phosphorylation (OXPHOS) and ATP production. In cells with defective OXPHOS, reductive ...
  • Bodily distribution of projectile injuries in Chilean protests 

    Cox, Pablo; Riveros, Rodrigo; Leiva, Camila; Carvajal, Yuri; Fuentes, Pablo; Recasens, Jaime; Covarrubias, Álvaro; Torres, Francisco; Ramírez, Daniel; Verdugo, Marcelo; Muñoz, Pablo (Elsevier, 2020)
  • Astaxanthin counteracts excitotoxicity and reduces the ensuing increases in calcium levels and mitochondrial reactive oxygen species generation 

    García, Francisca; Lobos, Pedro; Ponce, Alejandra; Cataldo, Karla; Meza, Daniela; Farías, Patricio; Estay, Carolina; Oyarzún Ampuero, Felipe; Herrera Molina, Rodrigo; Paula Lima, Andrea; Ardiles, Álvaro O.; Hidalgo Tapia, Cecilia; Adasme, Tatiana; Muñoz, Pablo (MDPI, 2020)
    Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-beta peptide oligomers, which promote excessive ...
  • Apuntes para el estudio de la salud mental en chile actual 

    González Hernández, Gabriela (Universidad de Buenos Aires, 2020)
    The current Chilean society has shown in diverse surveys to have a bad mental health at a general level. The following text is a bibliographic review that proposes some theoretical axes on which to analyse mental health ...
  • Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications 

    Carrillo Reixach, Juan; Torrens, Laura; Simon Coma, Marina; Royo, Laura; Domingo Sàbat, Montserrat; Abril Fornaguera, Jordi; Akers, Nicholas; Sala, Margarita; Ragull, Sonia; Arnal, Magdalena; Villalmanzo, Núria; Cairo, Stefano; Villanueva, Alberto; Kappler, Roland; Garrido, Marta; Guerra, Laura; Sábado, Constantino; Guillén, Gabriela; Mallo, Mar; Piñeyro, David; Vázquez Vitali, María; Kuchuk, Olga; Mateos, María Elena; Ramírez, Gema; López Santamaría, Manuel; Mozo, Yasmina; Soriano, Aroa; Grotzer, Michael; Branchereau, Sophie; García de Andoin, Nagore; López Ibor, Blanca; López Almaraz, Ricardo; Salinas, José Antonio; Torres, Bárbara; Hernández, Francisco; Uriz, José Javier; Fabre, Monique; Blanco, Julià; Paris Domínguez, Claudia; Bajčiová, Viera; Laureys, Geneviève; Masnou, Helena; Clos, Ariadna; Belendez, Cristina; Guettier, Catherine; Sumoy, Lauro; Planas, Ramón; Jordà, Mireia; Nonell, Lara; Czauderna, Piotr; Morland, Bruce; Sia, Daniela; Losic, Borjan; Buendia, Marie Annick; Sarrias, María Rosa; Llovet, Josep M.; Armengol, Carolina (Elsevier, 2020)
    Background & Aims: Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the predominant pediatric liver cancer, with limited therapeutic options for patients with aggressive tumors. Herein, we aimed to uncover the ...
  • Results of the endovascular treatment system for occluded native arteriovenous fistula 

    Leo, Christopher Cheang Han; Cassorla, Gabriel Jaime; Swinnen, Ian (Wiley, 2020)
    Background Arteriovenous fistula is the definitive vascular access for patients on long-term haemodialysis. The aim of this study is to present the techniques and results of the Endovascular Treatment System that we have ...
  • Protein kinase CK2 in cancer energetics 

    Silva Pavez, Eduardo; Tapia Pineda, Julio (Frontiers Media, 2020)
    Protein kinase CK2 (formerly known as casein kinase 2) is abnormally elevated in many cancers. This may increase tumor aggressiveness through CK2-dependent phosphorylation of key proteins in several signaling pathways. In ...
  • Pandemia y vacunas, ¿quimera o realidad? 

    George Carreño, Sergio; Torres Torreti, Juan Pablo; O'Ryan Gallardo, Miguel (Sociedad Médica Santiago, 2020)
  • Neonatal diabetes due to potassium channel mutation: Response to sulfonylurea according to the genotype 

    Garcin, Laure; Mericq Guila, Verónica; Fauret Amsellem, Anne Laure; Cave, Helene; Polak, Michel; Beltrand, Jaques (Wiley, 2020)
    Objective A precision medicine approach is used to improve treatment of patients with monogenic diabetes. Herein, we searched SU efficiency according to the genotype-phenotype correlation, dosage used, and side effects. ...
  • Conocimiento y uso de mecanismos de coordinación clínica de servicios de salud de Latinoamérica 

    Miranda Mendizábal, Andrea; Vargas, Ingrid; Mogollón Pérez, Amparo Susana; Eguiguren Bravo, Pamela; Ferreira de Medeiros Mendes, Marina; López, Julieta; Bertolotto, Fernando; Amarilla, Delia; Vázquez Navarretea, María Luisa (Elsevier, 2020)
    Objetivo: Analizar el nivel de conocimiento y uso, y las características del uso, de los mecanismos de coordinación clínica entre niveles de atención en redes de servicios de salud de seis países de Latinoamérica.Método: ...
  • Knobloch syndrome in a patient from Chile 

    Nakousi Capurro, Nicole; Huserman, Jonathan; Castillo, Silvia; Gavia Herrera, Luisa; Romero, Pablo; Pizarro, Felipe; Quezada, Cristian; Cea, Francisco (Wiley, 2020)
    Knobloch Syndrome (KS) is a rare autosomal recessive hereditary disease. Despite its clinical heterogeneity, it is characterized by vitreoretinal degeneration and high myopia, with or without occipital skull defects. It ...
  • Interactive guidance intervention to address sustained social withdrawal in preterm infants in Chile: Protocol for a randomized controlled trial 

    Bustamante Loyola, Jorge; Pérez Retamal, Marcelo; Morgues Nudman, Mónica Isabel; Maturana, Andrés; Salinas González, Ricardo; Cox, Horacio; González Mas, José Miguel; Muñoz, Lucía; López, Lilian; Mendiburo Seguel, Andrés; Simó, Sandra; Palau Subiela, Pascual; Guedeney, Antoine (2020)
    Background: Preterm newborns can be exposed early to significant perinatal stress, and this stress can increase the risk of altered socioemotional development. Sustained social withdrawal in infants is an early indicator ...
  • In vitro Treatment of a Murine Mammary Adenocarcinoma Cell Line with Recombinant Trypanosoma cruzi Calreticulin Promotes Immunogenicity and Phagocytosis 

    Sosoniuk Roche, Eduardo Rodrigo; Cruz, Pamela; Maldonado, Ismael; Duaso, Leonora; Pesce Reyes, Bárbara; Michalak, Marek; Valck Calderón, Carolina Eliana; Ferreira Vigouroux, Arturo (Elsevier, 2020)
    American Trypanosomiasis, a parasitic disease produced by Trypanosoma cruzi (T. cruzi), endemic in Latin America, infects about 6 million people. During the chronic stage of the infection, approximately 30% of infected ...
  • In vitro activity of isavuconazole against clinically isolated yeasts from Chile 

    Álvarez Duarte, Eduardo; Salas Duguet, Valentina (Springer, 2020)
    Isavuconazole is the last antifungal agent approved by the FDA and available for treatment of fungal infections. In the present study, the in vitro activity of isavuconazole against several yeasts was investigated. Two ...
  • Litoplastía iliaco-femoral para implante transcatéter de válvula aórtica 

    Veas, Nicolás; Soriano, Francesco; Winter, José; Nava, Stefano; Hameau, René; Lidefjeld, Dante; Valdebenito, Martín; Muñoz, Rodrigo; Oreglia, Jacopo (Sociedad Médica Santiago, 2020)
    Transcatheter aortic valve implantation (TAVI) has a lower perioperative risk than traditional surgery mostly when the transfemoral access is used. Some patients have anatomical conditions that contraindicate the use of ...
  • Hypoxia-related parameters during septic shock resuscitation: Pathophysiological determinants and potential clinical implications 

    Lorca Pavez, Nicolás; Kattan, Eduardo; Vera, Magdalena; Ferri, Giorgio; Valenzuela, Emilio Daniel; Alegría, Leyla; Bravo, Sebastián; Pairumani Medrano, Ronald; Santis Fuentes, César; Oviedo, Vanessa; Soto, Dagoberto; Ospina Tascón, Gustavo; Bakker, Jan; Hernández, Glenn; Castro, Ricardo (AME, 2020)
    Background: Assessment of tissue hypoxia at the bedside has yet to be translated into daily clinical practice in septic shock patients. Perfusion markers are surrogates of deeper physiological phenomena. Lactate-to-pyruvate ...
  • Global perspectives on immunization during pregnancy and priorities for future research and development: An international consensus statement 

    Abu-Raya, Bahaa; Maertens, Kirsten; Edwards, Kathryn M.; Omer, Saad B.; Englund, Janet A.; Flanagan, Katie L.; Snape, Matthew D.; Amirthalingam, Gayatri; Leuridan, Elke; Van Damme, Pierre; Papaevangelou, Vana; Launay, Odile; Dagan, Ron; Campins, Magda; Franca Cavaliere, Anna; Frusca, Tiziana; Guidi, Sofia; O’Ryan, Miguel; Heininger, Ulrich; Tan, Tan; Alsuwaidi, Ahmed R.; Safadi, Marco. A.; Vilca, Luz M.; Wanlapakorn, Nasamon; Madhi, Shabir A.; Giles, Michelle L.; Prymula, Roman; Ladhani, Shamez; Martinón Torres, Federico; Tan, Litjen; Michelin, Lessandra; Scambia, Giovanni; Principi, Nicola; Esposito, Susanna (Frontiers Media, 2020)
    Immunization during pregnancy has been recommended in an increasing number of countries. The aim of this strategy is to protect pregnant women and infants from severe infectious disease, morbidity and mortality and is ...

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