Now showing items 1-14 of 14

    • Conjugation of Kahalalide F with gold nanoparticles to enhance in vitro antitumoral activity 

      Hosta, Leticia; Pla-Roca, Mateu; Arbiol, Jordi; López Iglesias, Carmen; Samitier, Josep; Cruz, Luis; Kogan Bocian, Marcelo; Albericio, Fernando (2009)
      Two Cys-containing analogues of the anticancer drug Kahalalide F are synthesized and conjugated to 20 and 40 nm gold nanoparticles (GNPs). The resulting complexes are characterized by different analytical techniques to ...
    • Exploring the influence of diels–alder linker length on photothermal molecule release from gold nanorods 

      Vetterlein, Claudia; Vásquez Salfate, Rodrigo; Bolaños, Karen; Acosta, Gerardo A.; Guzman, Fanny; Albericio, Fernando; Celis, Freddy; Campos, Marcelo; Kogan Bocian, Marcelo; Araya, Eyleen (Elsevier, 2018-06)
      We studied the photothermal release of carboxyfluorescein (CF) linked to the gold surface of gold nanorods (GNRs) by two Diels-Alder adducts of different lengths (n = 4 and n = 9). The functionalized GNRs were irradiated ...
    • Exploring the influence of Diels–Alder linker length on photothermal molecule release from gold nanorods 

      Vetterlein, Claudia; Vásquez Salfate, Rodrigo; Bolaños, Karen; Acosta, Gerardo A.; Guzman, Fanny; Albericio, Fernando; Celis, Freddy; Campos, Marcelo; Kogan Bocian, Marcelo; Araya, Eyleen (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. We studied the photothermal release of carboxyfluorescein (CF) linked to the gold surface of gold nanorods (GNRs) by two Diels–Alder adducts of different lengths (n = 4 and n = 9). The functionalized ...
    • Gold nanoparticles as an efficient drug delivery system for GLP - 1 peptides 

      Pérez Ortiz, Magdalena; Zapata Urzua, Claudio; Acosta, Gerardo A.; Álvarez Lueje, Alejandro; Albericio, Fernando; Kogan Bocian, Marcelo (Elsevier, 2017)
      In this work, the potential application of gold nanoparticles for GLP-1 analogues delivery was studied. For this purpose, the original sequence of the incretin GLP-1 was slightly modified in the C-terminal region by adding ...
    • Gold nanoparticles as an efficient drug delivery system for GLP-1 peptides 

      Pérez Ortiz, Magdalena; Zapata Urzúa, Claudio Andrés; Acosta, Gerardo A.; Álvarez Lueje, Alejandro; Albericio, Fernando; Kogan Bocian, Marcelo (Elsevier B.V., 2017)
      © 2017 Elsevier B.V. In this work, the potential application of gold nanoparticles for GLP-1 analogues delivery was studied. For this purpose, the original sequence of the incretin GLP-1 was slightly modified in the ...
    • Gold nanoparticles for photothermally controlled drug release 

      Guerrero, Ariel R.; Hassan, Natalia; Escobar, Carlos A.; Albericio, Fernando; Kogan Bocian, Marcelo; Araya, Eyleen (Future Medicine Ltd., 2014)
      © 2014 Future Medicine Ltd. In this article, we describe how nanoparticles work in photothermally triggered drug delivery, starting with a description of the plasmon resonance and the photothermal effect, and how this is ...
    • Hantzsch dihydropyridines: Privileged structures for the formation of well-defined gold nanostars 

      Zapata Urzúa, Claudio; Pérez Ortiz, Magdalena; Acosta, Gerardo A.; Mendoza, Joan; Yedra, Lluis; Estradé, Sonia; Álvarez Lueje, Alejandro; Núñez Vergara, Luis; Albericio, Fernando; Lavilla, Rodolfo; Kogan Bocian, Marcelo (Elsevier, 2015)
      Anisotropic and branched gold nanoparticles have great potential in optical, chemical and biomedical applications. However their syntheses involve multi-step protocols and the use of cytotoxic agents. Here, we report a ...
    • Identification of peptides in flowers of Sambucus nigra with antimicrobial activity against aquaculture pathogens 

      Álvarez, Claudio; Barriga, Andrés; Albericio, Fernando; Romero, María; Guzman, Fanny (MDPI, 2018-05)
      The elder (Sambucus spp.) tree has a number of uses in traditional medicine. Previous studies have demonstrated the antimicrobial properties of elderberry liquid extract against human pathogenic bacteria and also influenza ...
    • Improving gold nanorod delivery to the central nervous system by conjugation to the shuttle Angiopep-2 

      Velasco Aguirre, Carolina; Morales Zavala, Francisco; Salas Huenuleo, Edison; Gallardo Toledo, Eduardo; Andonie, Oscar; Muñoz, Luis; Rojas, Ximena; Acosta, Gerardo; Sánchez Navarro, Macarena; Giralt, Ernest; Araya, Eyleen; Albericio, Fernando; Kogan Bocian, Marcelo (Future Medicine, 2017)
      Aim: To improve the in vivo delivery of gold nanorods (GNRs) to the central nervous system of rats, these gold nanoparticles were conjugated to Angiopep-2, a shuttle peptide that can cross the blood-brain barrier. Materials ...
    • Improving the brain delivery of gold nanoparticles by conjugation with an amphipathic peptide 

      Guerrero, Simon; Araya, Eyleen; Fiedler Temer, Jenny; Arias, J.; Adura, Carolina; Albericio, Fernando; Giralt, Ernest; Arias, José; Fernández, María Soledad; Kogan Bocian, Marcelo (2010)
      Background & aims: Gold nanoparticles (GNPs) have promising applications for drug delivery as well as for the diagnosis and treatment of several pathologies, such as those related to the CNS. However, GNPs are retained in ...
    • Multifunctionalized gold nanoparticles with peptides targeted to gastrin-releasing peptide receptor of a tumor cell line 

      Hosta-Rigau, Leticia; Olmedo, Ivonne; Arbiol, Jordi; Cruz, Luis J.; Kogan Bocian, Marcelo; Albericio, Fernando (2010)
      Functionalization of gold nanoparticles (AuNPs) with both a targeting peptide (an analogue of the peptide Bombesin) and a drug peptide ligand (an analogue of the RAF peptide) with the aim of improving selectivity in the ...
    • Peptides and metallic nanoparticles for biomedical applications 

      Kogan Bocian, Marcelo; Olmedo, Ivonne; Hosta, Leticia; Guerrero, Ariel; Cruz, Luis; Albericio, Fernando (2007)
      In this review, we describe the contribution of peptides to the biomedical applications of metallic nanoparticles. We also discuss strategies for the preparation of peptide-nanoparticle conjugates and the synthesis of the ...
    • Stable Conjugates of Peptides with Gold Nanorods for Biomedical Applications with Reduced Effects on Cell Viability 

      Adura, Carolina; Guerrero, Simón; Salas, Edison; Medel, Luis; Riveros, Ana; Mena, Juan; Arbiol, Jordi; Albericio, Fernando; Giralt, Ernest; Kogan Bocian, Marcelo (American Chemical Society, 2013)
      Gold nanorods used in therapy and diagnosis must be nontoxic and stable in biological media and should be specific for the target. The complete combination of these three factors has hindered the use of gold nanorods ...
    • Synthesis and in vivo evaluation of the biodistribution of a 18F-labeled conjugate gold-nanoparticle-peptide with potential biomedical application 

      Guerrero, Simon; Herance, José; Rojas, Santiago; Mena, Juan; Gispert, Juan; Acosta, Gerardo; Albericio, Fernando; Kogan Bocian, Marcelo (2012)
      Gold nanoparticles (AuNPs) have been extensively used in biological applications because of their biocompatibility, size, and ease of characterization, as well as an extensive knowledge of their surface chemistry. These ...