Browsing by Author "Quest, Andrew F. G."

Now showing items 41-60 of 73

    • Intracellular ca2+ increases and connexin 43 hemichannel opening are necessary but not sufficient for ... 
      Lagos Cabré, Raúl; Brenet, Marianne; Díaz, Jorge; Pérez, Ramón D.; Pérez, Leonardo A.; Herrera Molina, Rodrigo; Quest, Andrew F. G.; Leyton Campos, Lisette (MDPI AG, 2018)
      © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Under pro-inflammatory conditions, astrocytes become reactive and acquire a migratory phenotype. Our results show that hemichannels formed by connexin 43 (Cx43) ...
    • Intradermal DNA electroporation induces survivin-specific CTLs, suppresses angiogenesis and confers protection ... 
      Lladser, Álvaro; Ljungberg, Karl; Tufvesson, Helena; Tazzari, Marcella; Roos, Anna Karin; Quest, Andrew F. G.; Kiessling, Rolf (2010)
      Survivin is an intracellular tumor-associated antigen that is broadly expressed in a large variety of tumors and also in tumor associated endothelial cells but mostly absent in differentiated tissues. Naked DNA vaccines ...
    • Introduction to supramolecular complex formation in cell signaling and disease 
      Leyton Campos, Lisette; Quest, Andrew F. G. (Society of Biology of Chile, 2002)
      In summary, formation of multi-protein complexes is an essential if not defining feature of eukaryotic signaling. Clearly, we now appreciate this fact and are beginning to grasp some of the underlying guiding principles. ...
    • Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer 
      Cerda-Opazo, Paulina; Valenzuela Valderrama, Manuel; Wichmann, Ignacio; Rodríguez, Andrés; Contreras Reyes, Daniel Alberto; Fernández, Elmer A.; Carrasco Aviño, Gonzalo; Corvalán, Alejandro H.; Quest, Andrew F. G. (Impact Journals LLC, 2018)
      © Cerda-Opazo et al. BACKGROUND: The objective of the study was to determine the relationship between Survivin and Reprimo transcript/protein expression levels, and gastric cancer outcome. METHODS: In silico correlations ...
    • Inverse susceptibility to oxidative death of lymphocytes obtained from Alzheimer's patients and skin cancer ... 
      Behrens Pellegrino, María Isabel; Silva, Monica; Salech Morales, Felipe; Ponce, Daniela P.; Merino, Daniela; Sinning, Mariana; Xiong, Chengjie; Roe, Catherine M.; Quest, Andrew F. G. (2012)
      A paucity of cancer in individuals with Alzheimer's disease (AD) and low rates of AD in cancer survivors has been reported in epidemiological studies. Deregulation in opposite directions of biological mechanisms, such as ...
    • Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ... 
      Garrido, Maritza P.; Vera, Carolina; Vega Blanco, María Margarita; Quest, Andrew F. G.; Romero Osses, Carmen (SAGE Publications Inc., 2018)
      © The Author(s), 2018. Background: Epithelial ovarian cancer (EOC) is characterized by exacerbated angiogenesis regulated by proangiogenic and growth factors. Nerve growth factor (NGF) is overexpressed in EOC where it ...
    • Naked DNA immunization as an approach to target the generic tumor antigen survivin induces humoral and ... 
      Lladser, Álvaro; Párraga, Mario; Quevedo, Licarallén; Molina, Maria Carmen; Silva, Soledad; Ferreira, Arturo; Billetta, Rosario; Quest, Andrew F. G. (Elsevier GmbH, 2006)
      Survivin, a 16.5 kDa tumor associated antigen, is the smallest member of the inhibitor of apoptosis family that is abundantly expressed during development but essentially absent in normal adult tissues. Interestingly, ...
    • Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with αvβ3 ... 
      Avalos, Ana María; Valdivia, Alejandra D.; Muñoz, Nicolás; Herrera Molina, Rodrigo; Tapia, Julio C.; Lavandero González, Sergio; Chiong Lay, Mario; Burridge, Keith; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (2009)
      Clustering of αvβ3 integrin after interaction with the RGD-like integrin-binding sequence present in neuronal Thy-1 triggers formation of focal adhesions and stress fibers in astrocytes via RhoA activation. A putative ...
    • Oral dryness in Sjögren's syndrome patients. Not just a question of water 
      Castro, I.; Sepúlveda, D.; Cortés, J.; Quest, Andrew F. G.; Barrera, M. J.; Bahamondes, V.; Aguilera, S.; Urzúa, U.; Alliende, C.; Molina, C.; González, S.; Hermoso, M. A.; Leyton, C.; González, M. J. (2013)
      Sjögren's syndrome (SS) is a chronic autoimmune disease of undefined etiology. Patients with this syndrome suffer from severe alterations in both the quality and quantity of saliva and tears, due to impaired function of ...
    • Organelle communication: Signaling crossroads between homeostasis and disease 
      Bravo Sagua, Roberto; Torrealba Cárdenas, Natalia Belén; Paredes, Felipe; Morales, Pablo E.; Pennanen Saavedra, Christian; López Crisosto, Camila; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Chiong Lay, Mario; Hill, Joseph A.; Simmend, Thomas; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2014)
      Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are ...
    • Papel de HIF-1[alfa] en la transición desde la activación de PI3K hacia el arresto del ciclo celular ... 
      Canales Urriola, Jimena Andrea (Universidad de Chile, 2016)
      Helicobacter pylori (H. pylori) es una patógeno gástrico humano asociado al desarrollo de cáncer gástrico. En células epiteliales gástricas, la infección con H. pylori promueve la activación de diversas vías de señalización ...
    • Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic ... 
      Wehinger, Sergio; Ortiz, Rina; Díaz, María Inés; Aguirre, Adam; Valenzuela, Manuel; Llanos Vidal, Paola; Mc Master, Christopher; Leyton Campos, Lisette; Quest, Andrew F. G. (Elsevier, 2015)
      A considerable body of evidence exists implicating high levels of free saturated fatty acids in beta pancreatic cell death, although the molecular mechanisms and the signaling pathways involved have not been clearly ...
    • Pro-inflammatory cytokines enhance ERAD and ATF6 alpha pathway activity in salivary glands of Sjogren's ... 
      Barrera, María José; Aguilera, Sergio; Castro, Isabel; Cortés Araya, Juan Eliecer; Bahamondes Lorca, Verónica; Quest, Andrew F. G.; Molina, Claudio; González, Sergio; Hermoso Ramello, Marcela; Urzúa Tobar, Ulises; Leyton, Cecilia; González Burgos, María Julieta (Elsevier, 2016)
      Salivary gland (SG) acinar-cells are susceptible to endoplasmic reticulum (ER) stress related to their secretory activity and the complexity of synthesized secretory products. SGs of Sji5gren's syndrome patients (SS)-patients ...
    • Progesterone utilizes distinct membrane pools of tissue factor to increase coagulation and invasion and ... 
      Henríquez, Soledad; Calderón, Claudia; Quezada, Marisol; Oliva, Bárbara; Bravo, Maria Loreto; Aranda, Evelyn; Kato, Sumie; Cuello, Mauricio A.; Gutiérrez, Jorge; Quest, Andrew F. G.; Owen, Gareth I. (2011)
      Tissue factor (TF) serving as the receptor for coagulation factor VII (FVII) initiates the extrinsic coagulation pathway. We previously demonstrated that progesterone increases TF, coagulation and invasion in breast cancer ...
    • Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and ... 
      Yefi, Roger; Ponce, Daniela P.; Niechi, Ignacio; Silva, Eduardo; Cabello, Pablo; Rodriguez, Diego A.; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Quest, Andrew F. G.; Tapia, Julio C. (2011)
      Augmented expression of protein kinase CK2 is associated with hyperproliferation and resistance to apoptosis in cancer cells. Effects of CK2 are at least partially linked to signaling via the Wnt/β-catenin pathway, which ...
    • Rab5 is required in metastatic cancer cells for caveolin-1-enhanced Rac1 activation, migration and invasion 
      Díaz, Jorge; Mendoza, Pablo; Ortiz, Rina; Díaz, Natalia; Leyton Campos, Lisette; Stupack, Dwayne; Quest, Andrew F. G.; Torres, Vicente A. (Company of Biologists Ltd, 2014)
      Rab5 is a small GTPase that regulates early endosome trafficking and other cellular processes, including cell adhesion and migration. Specifically, Rab5 promotes Rac1 activation and cancer cell migration, but little is ...
    • Reduced sulfation of MUC5B is linked to xerostomia in patients with Sjögren syndrome 
      Alliende, C.; Kwon, Y. J.; Brito, M.; Molina, C.; Aguilera, S.; Pérez, P.; Leyton, L.; Quest, Andrew F. G.; Mandel, U.; Veerman, E.; Espinosa, M.; Clausen, H.; Leyton, C.; Romo, R.; González, M. J. (2008)
      Objectives: MUC5B contains sulfated and sialylated oligosaccharides that sequester water required for moisturising the oral mucosa. Xerostomia, in patients with Sjo¨gren syndrome, is generally associated with ...
    • Regulación de la compartimentalización de la comunicación retículo endoplásmico-mitocondria en la línea ... 
      Bravo Sagua, Roberto (Universidad de Chile, 2015)
      El retículo endoplásmico (RE) y la mitocondria son organelos celulares que entablan una continua y dinámica conversación que permite a la célula responder coordinadamente a diversas situaciones fisiopatológicas. ...
    • Rol de caveolina-1 en la quimiotaxis de las células dendríticas hacia los nódulos linfáticos 
      Cruz Gómez, Sebastián Matías (Universidad de Chile, 2017)
      Las células dendríticas (DCs) son células presentadoras de antígeno capaces de capturar y procesar antígenos que luego son presentados a linfocitos T específicos en órganos linfoides. Para activar a los linfocitos T, las ...
    • Rol de la respuesta a proteínas mal plegadas en la actividad supresora de tumores de Caveolina-1 
      Díaz Morales, María Inés (Universidad de Chile, 2015)
      El cáncer es la segunda causa de muerte a nivel mundial y en Chile luego de las enfermedades cardiovasculares. Importantemente, las muertes por cáncer van en aumento. Los avances más recientes en el entendimiento de las ...