Browsing by Author "Hetz Flores, Claudio"

Now showing items 1-5 of 5

    • Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons 
      Klein, Andres; Maldonado, Carola; Vargas, Lina M.; Gonzalez, Marcela; Robledo, Fermín; Perez de Arce, Karen; Muñoz, Francisco J.; Hetz Flores, Claudio; Alvarez, Alejandra R.; Zanlungo, Silvana (2011)
      Niemann-Pick type C (NPC) is a neurodegenerative disease characterized by the intralysosomal accumulation of cholesterol leading to neuronal apoptosis. We have previously reported the activation of the c-Abl/p73 proapoptotic ...
    • Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis 
      Nassif, Melissa; Valenzuela, Vicente; Rojas Rivera, Diego; Vidal, René; Matus, Soledad; Castillo, Karen; Fuentealba, Yerko; Kroemer, Guido; Levine, Beth; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)
      Pharmacological activation of autophagy is becoming an attractive strategy to induce the selective degradation of aggregate-prone proteins. Recent evidence also suggests that autophagy impairment may underlie the pathogenesis ...
    • Rol del factor de transcripción XBP1s en la enfermedad de Alzheimer 
      Acevedo Valdivieso, Javiera Fernanda (Universidad de Chile, 2017)
      La pérdida de homeostasis proteica (proteostasis) es una de las características principales de la enfermedad de Alzheimer (EA), asociada con la generación de estrés del retículo endoplásmico (RE) y la agregación anormal ...
    • Stressing out the ER: A role of the unfolded protein response in prion-related disorders 
      Hetz Flores, Claudio; Soto, Claudio (2006)
      Transmissible Spongiform Encephalopathies are fatal and infectious neurodegenerative diseases characterized by extensive neuronal apoptosis and the accumulation of an abnormally folded form of the cellular prion protein ...
    • Targeting autophagy in neurodegenerative diseases 
      Vidal, René L.; Matus, Soledad; Bargsted, Leslie; Hetz Flores, Claudio (Elsevier Ltd, 2014)
      © 2014 Elsevier B.V. All rights reserved. The most prevalent neurodegenerative disorders involve protein misfolding and the aggregation of specific proteins. Autophagy is becoming an attractive target to treat neurodegenerative ...