Browsing by Author "Mella Raipán, Jaime A."
Now showing items 1-7 of 7
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Vásquez, David; Lagos González, Carlos F.; Mella Raipán, Jaime A.; González, Luis; Ebensperger González, Roberto; Alvarez Figueroa, M. Javiera; Sáez, Edmundo; Pessoa Mahana, Hernán; Araya Secchi, Raúl; González Wong, Angel; Pérez-Acle, Tomás; Pessoa, D. (SOC CHILENA QUIMICA, 2007-12)A novel approach to the development of anew class of HIV-1 RT inhibitors is reported. The 1-benzoyl-2-aryl-1H-benzimidazole series was designed as a combination of two previously reported active scaffolds, the benzimidazole ...
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Mella Raipán, Jaime A.; Lagos, Carlos F.; Recabarren Gajardo, Gonzalo Iván; Espinosa Bustos, Christian; Romero Parra, Javier; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Carlos David (2013)A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 ...
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Mella Raipán, Jaime A.; Lagos, Carlos F.; Recabarren Gajardo, Gonzalo Iván; Espinosa Bustos, Christian; Romero Parra, Javier; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Carlos David (2013)A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 ...
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Espinosa Bustos, Christian; Lagos, Carlos F.; Romero Parra, Javier; Zárate, Ana M.; Mella Raipán, Jaime A.; Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Iturriaga-Vásquez, Patricio; Tapia, Ricardo A.; Pessoa Mahana, Carlos David (Wiley-VCH Verlag, 2015)© 2015 Wiley-VCH Verlag GmbH & Co. KGaA. A series of N-acyl-2,5-dimethoxyphenyl-1H-benzimidazoles were designed based on a CoMFA model for cannabinoid receptor type 1 (CB1) ligands. Compounds were synthesized and radioligand ...
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Pessoa, D.; Espinosa Bustos, Christian; Mella Raipán, Jaime A.; Canales Pacheco, Jorge; Pessoa Mahana, Hernán (ARKAT USA INC, 2009)The synthesis of 5H-benzimidazo [1,2-d] [1,4] benzodiazepin -6(7H)-ones 3a-e from readily available 2-(2-aminophenyl)-1H-benzo[d]imidazole derivatives 2a-e and 2-bromoacetyl bromide under microwave conditions is described. ...
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Pessoa Mahana, David; Núñez, Andrés; Espinosa Bustos, Christian; Mella Raipán, Jaime A.; Pessoa Mahana, Hernán (2010)The synthesis of a series of substituted arylpiperazines linked to a 2-(pyridin-3-yl)-1H-benzo[d]imidazole scaffold through an alkylic linker is reported. The novel 1-(2-(4-arylpiperazin-1-yl)alkyl)-2-(pyridin-3-yl)-1H-b ...
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Pessoa Mahana, David; Núñez, Andrés; Espinosa Bustos, Christian; Mella Raipán, Jaime A.; Pessoa Mahana, Hernán (2010)