Browsing by Author "Porcal, Williams"

Now showing items 1-5 of 5

    • Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, ... 
      Castro, Diego; Boiani, Lucía; Benítez, Diego; Hernández, Paola; Merlino, Alicia; Gil, Carmen; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo; Porcal, Williams (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2009-12)
      Hybrid vinylthio-, vinylsulfinyl-, vinylsulfonyl- and vinylketo-benzofuroxans developed as anti-trypanosomatid agents, against Trypanosoma cruzi and Leishmania spp., have showed low micromolar IC50 values. The synthetic ...
    • Electrochemical and microsomal production of free radicals from 1,2,5-oxadiazole N-oxide as potential ... 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Briones, Rodolfo; Cerecetto, Hugo; Di Maio, R.; Risso, Mariela; González, M.; Porcal, Williams (PERGAMON-ELSEVIER SCIENCE LTD, 2003-01-01)
      The electron spin resonance (ESR) spectra of free radicals obtained by electrolytic or microsomal reduction of several potential antiprotozoal 1,2,5-oxadiazoles were characterized and analyzed. Ab initio molecular orbital ...
    • ESR and spin trapping studies of two new potential antitrypanosomal drugs 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Opazo, L.; Morello Casté, Antonio; Maya Arango, Juan; Repetto Scaramelli, Yolanda; Aguirre, G.; Cerecetto, Hugo; Di Maio, R.; González, M.; Porcal, Williams (SOCIEDAD CHILENA DE QUIMICA, 2003-12)
      The Electron Spin Resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by Trypanosoma cruzi reduction were analyzed. DMPO Spin Trapping was used to investigate the possible formation ...
    • New heteroaryl nitrones with spin trap properties: Identification of a 4-furoxanyl derivative with excellent ... 
      Barriga, Germán; Olea Azar, Claudio; Norambuena, Ester; Castro, Ana; Porcal, Williams; Gerpe, Alejandra; González, Mercedes; Cerecetto, Hugo (ELSEVIER, 2010)
      A new series of heteroaryl nitrones, 1–7, bearing furoxanyl and thiadiazolyl moieties, were evaluated for their free radical-trapping properties. The physicochemical characterization by electron paramagnetic resonance ...
    • Spin Trapping: An Essential Tool for the Study of Diseases Caused by Oxidative Stress 
      Barriga González, Germán; Olea Azar, Claudio; Zúñiga López, María C.; Folch Cano, Christian; Aguilera Venegas, Benjamín; Porcal, Williams; González, Mercedes; Cerecetto, Hugo (Bentham Science Publ, 2015)
      Electron spin resonance (ESR), called also electron paramagnetic resonance (EPR) together with the spin trapping technique, has allowed us to study and understand how free radicals are involved in various pathologies. In ...