Browsing by Author "Zapata Torres, Gerald"
Now showing items 1-15 of 15
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Pérez, Patricia; Zapata Torres, Gerald; Parra Mouchet, Julia; Contreras Ramos, Renato (John Wiley and Sons Inc., 1999)The effect of the basicity of methyl-amines on hydrogen bonding (HB) with HCOOH is examined in both gas and solution phases. In the gas phase, the strength of HB may be related to the proton affinity (PA) difference between ...
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Díaz Seguel, Alfredo Exequiel (Universidad de Chile, 2019)Varios estudios relacionados con el tratamiento de enfermedades neurodegenerativas (EN) han mostrado que moléculas inhibidoras de Monoamino Oxidasas (iMAO) disminuyen los efectos asociados a éstas, entre ellos se encuentra ...
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Faúndez Reyes, Erick Giovanni (Universidad de Chile, 2016)En esta tesis se estudió la complejación de los ligandos 6-([1,2,3]Triazolo[1,5-a]piridin-3-il)piridin-2-il)piridin-2-il)metanona (TPPM) y 3-(1H-benzimidazol-2-il)-7-(dietilamino) cromen-2-ona (C7) con 2,6 dimetil-β-ciclodextrina ...
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Valdebenito Silva, Silvana Abisag (Universidad de Chile, 2016)En esta tesis se estudiaron tanto las características fisicoquímicas de los complejos de inclusión de derivados de ariloxazinonas y arilnaftoxazoles en ciclodextrinas y se determinaron los parámetros termodinámicos que ...
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Zapata Torres, Gerald; Fierro, Angelica; Miranda Rojas, Sebastián; Guajardo, Carlos; Sáez Briones, Patricio; Salgado, J. Cristian; Celis Barros, Cristian (2012)Although substrate conversion mediated by human monoaminooxidase (hMAO) has been associated with the deprotonated state of their amine moiety, data regarding the influence of protonation on substrate binding at the active ...
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Zanocco, Renzo P.; Valdebenito, Silvana; Gidi, Yasser; Zapata Torres, Gerald; Lemp Miranda, Else; Nonell, Santi; Zanocco Loyola, Antonio (Blackwell Publishing Inc., 2018)© 2018 The American Society of Photobiology Naphthoxazole derivatives are small heterocyclic compounds endowed with outstanding fluorescence properties. In this work, we report a detailed study of the intense white light ...
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Berríos Cárcamo, Pablo; Rivera Meza, Mario; Herrera Marschitz, Mario; Zapata Torres, Gerald (Blackwell Publishing Ltd, 2019)(R/S)-Salsolinol is a full agonist of the μ-opioid receptor (μOR) Gi protein pathway via its (S)-enantiomer and is functionally selective as it does not promote β-arrestin recruitment. Compared to (S)-salsolinol, the ...
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Scorza, Cecilia; Carrau, Cecilia; Silveira, Rodolfo; Zapata Torres, Gerald; Cassels Niven, Bruce; Reyes Parada, Miguel (1997)The monoamine oxidase (MAO) inhibitory properties of a series of amphetamine derivatives with different substituents at or around the para position of the aromatic ring were evaluated. In in vitro studies in which a crude ...
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Galvis Pareja, David; Zapata Torres, Gerald; Hidalgo Tapia, Jorge; Ayala, Pedro; Pedrozo Cibils, Zully; Ibarra, Cristián; Díaz Araya, Guillermo; Hall, Andrew R.; Vicencio, José Miguel; Núñez Vergara, Luis; Lavandero González, Sergio (Elsevier, 2014)Rationale: Dihydropyridines are widely used for the treatment of several cardiac diseases due to their blocking activity on L-type Ca2+ channels and their renowned antioxidant properties. Methods: We synthesized six novel ...
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Rubio Gallardo, Pedro (Universidad de Chile, 2021)El CO2 es sin lugar a duda una preocupación en el contexto de la química ambiental, por su contribución al calentamiento global y por su carácter inerte. Los esfuerzos se centran en la búsqueda de formas para su reutilización ...
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Toro Sazo, Miguel Ángel (Universidad de Chile, 2019)Se sintetizó una familia de derivados de triptamina y unos pocos análogos de 5- metoxitriptamina con sustituciones diferentes en el bencilo y se realizaron ensayos in vitro de afinidad y actividad funcional para los ...
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Jullian Matthaei, Carolina; Fernández Sandoval, Samuel Esteban; Celis Barros, Cristian; Abarca, Belén; Ballestero, Rafael; Zapata Torres, Gerald (Elsevier, 2015)tThe chemosensor 3-phenyl-7-(pyrid-2-yl)-[1,2,3]triazolo[1,5-a]pyridine (PhPTP) used in combinationwith two different cyclodextrins, enable its solubilization and stabilization in aqueous solution. Thebehavior of the ...
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Pessoa Mahana, Hernán; Silva Matus, Paul Eduardo; Pessoa Mahana, Carlos David; Chung, Hery; Iturriaga-Vásquez, Patricio; Quiroz, Gabriel; Möller-Acuña, Patricia; Zapata Torres, Gerald; Saitz Barría, Claudio; Araya Maturana, Ramiro; Reyes Parada, Miguel (Wiley, 2017)A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the ...
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Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Temer, Jenny Fiedler; Zapata Torres, Gerald; Pessoa Mahana, Carlos David; Barría, Claudio Saitz; Araya Maturana, Ramiro (2012)A series of novel benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1- one derivatives 6a-f, 7a-f and their corresponding alcohols 8a-f were synthesized and evaluated for their affinity towards 5-HT 1A receptors. The ...
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Bollo Dragnic, Soledad; Jara Ulloa, Paola Andrea; Zapata Torres, Gerald; Cutiño,; Sturm,; Núñez Vergara, Luis; Squella Serrano, Juan (Elsevier Ltd, 2010)The voltammetric reduction of 1-methyl- and 1-H- 4-nitroimidazole derivatives was studied in different protic and aprotic media to investigate the influence of the N-1 substitution in the mechanism of reduction, the ...