Browsing by Subject "Calcium"

Now showing items 1-9 of 9

    • Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes 
      Gutiérrez, Tomás; Parra, Valentina; Troncoso, Rodrigo; Pennanen, Christian; Contreras Ferrat, Ariel Eduardo; Vásquez Trincado, César Alonso; Morales, Pablo E.; López Crisosto, Camila; Sotomayor Flores, Cristian Alejandro; Chiong Lay, Mario; Rothermel, Beverly A.; Lavandero González, Sergio (BioMed Central Ltd., 2014)
      © 2014 Gutierrez et al.; licensee BioMed Central Ltd. Background: Cardiac hypertrophy is characterized by alterations in both cardiac bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes ...
    • Ca2+, autophagy and protein degradation: Thrown off balance in neurodegenerative disease 
      Vicencio, José Miguel; Lavandero González, Sergio; Szabadkai, Gyorgy (ELSEVIER, 2010)
      Substantial progress has been made throughout the last decades in the elucidation of the key players and mechanisms responsible for Ca2+ signal generation in both excitable and non-excitable cells. Importantly, these ...
    • Calcium mediates the activation of the inhibitory current induced by odorants in toad olfactory receptor neurons 
      Morales, Bernardo; Madrid, Rodolfo; Bacigalupo Vicuña, Juan (1997)
      In toad olfactory neurons, a putrid odorant mixture inducing inhibitory responses increases Ca2+-activated K+ conductance, developing a hyperpolarizing receptor potential. Removal of extracellular Ca2+ or exposure to ...
    • Herpudl impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt ... 
      Navarro Márquez, Mario F.; Torrealba, Natalia; Troncoso, Rodrigo; Vásquez Trincado, César; Rodríguez, Marcelo; Morales, Pablo E.; Villalobos, Elisa; Eura, Yuka; García Nannig, Lorena; Chiong Lay, Mario; Klip, Amira; Jaimovich Pérez, Enrique; Kokame, Koichi; Lavandero González, Sergio (Elsevier, 2018)
      Skeletal muscle plays a central role in insulin-controlled glucose homeostasis. The molecular mechanisms related to insulin resistance in this tissue are incompletely understood. Herpud1 is an endoplasmic reticulum membrane ...
    • Mitochondria, myocardial remodeling, and cardiovascular disease 
      Verdejo, Hugo; Campo, Andrea del; Troncoso, Rodrigo; Gutiérrez, Tomás; Toro, Barbra; Quiroga, Clara; Pedrozo Cibils, Zully; Muñoz, Juan; García Nannig, Lorena; Castro, Pablo; Lavandero González, Sergio (2012)
      The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
    • A novel dihydropyridine with 3-aryl meta-hydroxyl substitution blocks L-type calcium channels in rat cardiomyocytes 
      Galvis Pareja, David; Zapata Torres, Gerald; Hidalgo Tapia, Jorge; Ayala, Pedro; Pedrozo Cibils, Zully; Ibarra, Cristián; Díaz Araya, Guillermo; Hall, Andrew R.; Vicencio, José Miguel; Núñez Vergara, Luis; Lavandero González, Sergio (Elsevier, 2014)
      Rationale: Dihydropyridines are widely used for the treatment of several cardiac diseases due to their blocking activity on L-type Ca2+ channels and their renowned antioxidant properties. Methods: We synthesized six novel ...
    • Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced ... 
      Chiong Lay, Mario; Parra, V.; Eisner, V.; Ibarra, C.; Maldonado, C.; Criollo Céspedes, Alfredo; Bravo, R.; Quiroga, C.; Contreras, A.; Vicencio Bustamante, José; Cea, P.; Bucarey, J.; Molgó, Jordi; Jaimovich Pérez, Enrique; Hidalgo Tapia, María Cecilia; Kroemer, G.; Lavandero González, Sergio (2010)
      Hyperosmotic stress promotes rapid and pronounced apoptosis in cultured cardiomyocytes. Here, we investigated if Ca2+ signals contribute to this response. Exposure of cardiomyocytes to sorbitol [600 mosmol (kg water)(-1)] ...
    • Polycystin-1 is required for insulin-like growth factor 1-induced cardiomyocyte hypertrophy 
      Fernández, Carolina; Torrealba, Natalia; Altamirano, Francisco; Garrido Moreno, Valeria Soraya; Vásquez Trincado, César; Flores Vergara, Raúl Alejandro; López Crisosto, Camila; Ocaranza, María Paz; Chiong Lay, Mario Martin; Pedrozo Cibils, Zully Rocío Evangelina; Lavandero González, Sergio (Public Library Science, 2021)
      Cardiac hypertrophy is the result of responses to various physiological or pathological stimuli. Recently, we showed that polycystin-1 participates in cardiomyocyte hypertrophy elicited by pressure overload and mechanical ...
    • Regulation of cardiomyocyte autophagy by calcium 
      Shaikh, Soni; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Bravo Sagua, Roberto; García Nannig, Lorena; Morselli, Eugenia; Cifuentes, Mariana; Quest, Andrew F. G.; Hill, Joseph A.; Lavandero González, Sergio (Amer Physiological Soc, 2016)
      Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion ...