Browsing by Subject "Therapy"

Now showing items 1-5 of 5

    • Alzheimer's and prion disease as disorders of protein conformation: Implications for the design of novel ... 
      Soto, Claudio (1999)
      Several lines of evidence suggest that a defective protein folding is a central event in both Alzheimer's and prion disease. Although the two disorders are very different clinically, neuropathologically, and biochemically, ...
    • CLPFFD-PEG functionalized NIR-absorbing hollow gold nanospheres and gold nanorods inhibit beta-amyloid aggregation 
      Ruff, J.; Hassan, N.; Morales Zavala, Francisco; Steitz, J.; Araya, E.; Kogan Bocian, Marcelo; Simon, U. (Royal Soc Chemistry, 2018-04-28)
      Gold nanoparticles with specific optical properties in combination with the CLPFFD peptide that exhibits selectivity for beta-amyloid (A beta) aggregates are promising photothermal absorbers for application in Alzheimer's ...
    • In vitro and in vivo antitrypanosomatid activity of 5-nitroindazoles 
      Boiani, Lucia; Gerpe, Alejandra; Arán, Vicente; Torres de Ortiz, Susana; Serna, Elva; Vera de Bilbao, Ninfa; Sanabria, Luis; Yaluff, Gloria; Nakayama, Héctor; Rojas de Arias, Antonieta; Maya Arango, Juan; Morello, J.; Cerecetto, Hugo; González, Mercedes (2009)
      Previously, we have identified a series of 5-nitroindazoles with good antiprotozoal activities, against Trypanosoma cruzi epimastigotes and Trichomonas vaginalis. Most of them have shown very low unspecific toxicity on ...
    • Mutational landscape and actionable target rates on advanced stage refractory cancer patients: a multicenter ... 
      Córdova Delgado, Miguel Angel; Pinto, Mauricio P.; Regonesi, Carlos; Cereceda, Luis; Reyes, José Miguel; Itriago, Laura; Majlis, Alejandro; Rodríguez, Pablo; Fassler, André; Mahave, Mauricio; León, María Elisa; Gallardo, Jorge; Rodríguez Z., María Paz; Berkovits, Alejandro; Manque, Patricio; Ríos, Juvenal A.; García Bloj, Benjamín; Garrido, Marcelo (MDPI, 2022)
      Major advances in sequencing technologies and targeted therapies have accelerated the incorporation of oncology into the era of precision medicine and "biomarker-driven" treatments. However, the impact of this approach on ...
    • Vaccines against components of the renin-angiotensin system 
      Garay Gutiérrez, Noé Francisco; Hernández Fuentes, Carolina; García Rivas, Gerardo; Lavandero González, Sergio; Guerrero Beltrán, Carlos Enrique (Springer, 2020)
      Even though effective drugs for treating hypertension are available, a great percentage of patients have inadequate control of their blood pressure. Unwanted side effects and inappropriate oral drug adherence are important ...