Browsing by Author "9e53d4b8-3402-4486-b627-0ca912310dd5"

Now showing items 1-8 of 8

    • Angiotensin (1-7) decreases myostatin-induced NF-kappa B signaling and skeletal muscle atrophy 
      Aravena, Javier; Abrigo, Johanna; González, Francisco; Aguirre, Francisco; González, Andrea; Simon Pino, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)
      Myostatin is a myokine that regulates muscle function and mass, producing muscle atrophy. Myostatin induces the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. The main pathway that mediates ...
    • Angiotensin-(1-7) prevents lipopolysaccharide-induced autophagy via the mas receptor in skeletal muscle 
      Rivera, Juan Carlos; Abrigo, Johanna; Tacchi, Franco; Simón, Felipe; Brandan, Enrique; Santos, Robson A.; Bader, Michael; Chiong Lay, Mario; Cabello Verrugio, Claudio (MDPI, 2020)
      Skeletal muscle atrophy, which occurs in lipopolysaccharide (LPS)-induced sepsis, causes a severe muscle function reduction. The increased autophagy contributes to sepsis-induced skeletal muscle atrophy in a model of LPS ...
    • Inhibition of trpm7 protects against inflammatory cytokine overproduction, multiple organ dysfunction, and ... 
      Gatica, Sebastián; Villegas, Vicente; Vallejos, Alejandro; Cabello Verrugio, Claudio; Varela Lekanda, Diego; Simón, Felipe (Lippincott Williams & Wilkins, 2020)
    • Protective effect of Angiotensin 1–7 on Sarcopenia induced by chronic liver disease in mice 
      Aguirre, Francisco; Abrigo, Johanna; Altimiras González, Francisco; González, Andrea; Simon, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)
      Sarcopenia associated with chronic liver disease (CLD) is one of the more common extrahepatic features in patients with these pathologies. Among the cellular alterations observed in the muscle tissue under CLD is the decline ...
    • Sarcopenia induced by chronic liver disease in mice requires the expression of the bile acids membrane ... 
      Abrigo, Johanna; Campos, Fabián; González, Francisco; Aguirre, Francisco; González, Andrea; Huerta Salgado, Camila; Conejeros, Sabrina; Simon, Felipe; Arrese, Marco; Cabrera, Daniel; Elorza, Alvaro A.; Cabello Verrugio, Claudio (MDPI, 2020)
      Sarcopenia is a condition of muscle dysfunction, commonly associated with chronic liver disease (CLD), characterized by a decline in muscle strength, the activation of the ubiquitin-proteasome system (UPS), and oxidative ...
    • SARS-CoV-2/Renin–angiotensin system: Deciphering the clues for a couple with potentially harmful effects ... 
      González, Andrea; Orozco Aguilar, Josué; Achiardi, Óscar; Simon, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)
      Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has produced significant health emergencies worldwide, resulting in the declaration by the World Health Organization of the coronavirus disease 2019 (COVID-19) ...
    • TRPM Channels in Human Diseases 
      Jiménez, Ivanka; Prado, Yolanda; Marchant, Felipe; Otero, Carolina; Eltit, Felipe; Cabello Verrugio, Claudio; Cerda Arancibia, Óscar; Simón, Felipe (MDPI, 2020)
      The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been made in identifying novel members of the TRPM ...
    • TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia 
      Gatica, Sebastián; Villegas, Vicente; Vallejos, Alejandro; Olivares, Pedro; Aballai, Víctor; Lagos Meza, Felipe; Echeverría, César; Cabello Verrugio, Claudio; Varela Lekanda, Diego; Simón, Felipe (Nature Publishing Group, 2020)
      Acute kidney injury and endothelial hyperpermeability are main features observed during severe sepsis with low survival rate. Transient receptor potential melastatin 7 (TRPM7) calcium channel inhibition protects against ...