Browsing by Author "f0295a9b-5595-4e10-8cfe-98f0765104e3"
Now showing items 21-40 of 54
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Llanos Vidal, Paola; Contreras Ferrat, Ariel Eduardo; Barrientos, Genaro; Valencia, Marco; Mears, David; Hidalgo Tapia, María Cecilia (Public Library of Science, 2015)© 2015, Public Library of Science. All rights reserved. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for ...
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Riquelme, Denise; Álvarez, Alvaro; Leal, Nancy; Adasme, Tatiana; Espinoza, Italo; Valdés, Juan Antonio; Troncoso, Natalia; Härtel, Steffen; Hidalgo Tapia, Jorge; Hidalgo Tapia, María Cecilia; Carrasco Friz, María Angélica (2011)Neuronal electrical activity increases intracellular Ca2+ concentration and generates reactive oxygen species. Here, we show that high frequency field stimulation of primary hippocampal neurons generated Ca2+ signals with ...
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Riquelme, Denise; Alvarez, Alvaro; Leal, Nancy; Adasme, Tatiana; Espinoza, Italo; Valdés, Juan Antonio; Troncoso, Natalia; Hartel, Steffen; Segura Hidalgo, Jorge Antonio; Hidalgo Tapia, María Cecilia; Carrasco, M. Angélica (2011)Neuronal electrical activity increases intracellular Ca2+ concentration and generates reactive oxygen species. Here, we show that high frequency field stimulation of primary hippocampal neurons generated Ca 2+ signals with ...
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Osorio Fuentealba, César; Valdés, Juan Antonio; Riquelme, Denise; Segura Hidalgo, Jorge Antonio; Hidalgo Tapia, María Cecilia; Carrasco, María Angélica (2009)Mammalian cells sense oxygen levels and respond to hypoxic conditions through the regulation of multiple signaling pathways and transcription factors. Here, we investigated the effects of hypoxia on the activity of two ...
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Aracena Parks, Paula; Goonasekera, Sanjeewa A.; Gilman, Charles P.; Dirksen, Robert T.; Hidalgo Tapia, María Cecilia; Hamilton, Susan L. (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2006-12-29)The skeletal muscle Ca2+-release channel ( ryanodine receptor type 1 (RyR1)) is a redox sensor, susceptible to reversible S-nitrosylation, S-glutathionylation, and disulfide oxidation. So far, Cys-3635 remains the only ...
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Haeger, Paola; Alvarez, Alvaro; Leal, Nancy; Adasme, Tatiana; Núñez González, Marco; Hidalgo Tapia, María Cecilia (2010)Iron is essential for crucial neuronal functions but is also highly toxic in excess. Neurons acquire iron through transferrin receptor-mediated endocytosis and via the divalent metal transporter 1 (DMT1). The N-terminus ...
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Adasme, Tatiana; Paula Lima, Andrea; Hidalgo Tapia, María Cecilia (Elsevier, 2015)Ryanodine is a cell permeant plant alkaloid that binds selectively and with high affinity to ryanodine receptor (RyR) Ca2þ release channels. Sub-micromolar ryanodine concentrations activate RyR channels while micromolar ...
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Hidalgo Tapia, María Cecilia; Jaimovich Pérez, Enrique (Kluwer Academic Publishers-Plenum Publishers, 1989)The role of inositol trisphosphate as a chemical messenger in excitation-contraction coupling is discussed, both in terms of positive and negative results. The evidence presented includes experiments on the effect of ...
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Adasme, Tatiana; Haeger, Paola; Paula Lima, Andrea; Espinoza, Italo; Casas-Alarcón, M. Mercedes; Carrasco Friz, María Angélica; Hidalgo Tapia, María Cecilia (NATL ACAD SCIENCES, 2011-02-15)Ryanodine receptors (RyR)amplify activity-dependent calciuminflux via calcium-induced calcium release. Calcium signals trigger postsynaptic pathways in hippocampal neurons that underlie synaptic plasticity, learning, ...
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Jaimovich Pérez, Enrique; Donoso Laurent, Paulina; Liberona Leppe, José; Hidalgo Tapia, María Cecilia (Elsevier, 1986)The presence of four cation pathways in membrane vesicles isolated from transverse tubules of frog and rabbit skeletal muscle was studied by measuring binding of specific blockers. Transverse tubules purified from frog ...
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Bull Simpfendorfer, Ricardo; Finkelstein, José Pablo; Gálvez, Jorge; Sánchez, Gina; Donoso Laurent, Paulina; Behrens Pellegrino, María Isabel; Hidalgo Tapia, María Cecilia (2008)Cerebral ischemia stimulates Ca2+influx and thus increases neuronal intracellular free [Ca2+. Using a rat model of cerebral ischemia without recirculation, we tested whether ischemia enhances the activation by Ca2+ of ...
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Sánchez, Gina; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (Biophysical Society, 2003)Fast Ca2+ release kinetics were measured in cardiac sarcoplasmic reticulum vesicles actively loaded with Ca2+. Release was induced in solutions containing 1.2 mM free ATP and variable free [Ca2+] and [Mg2+]. Release rate ...
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Donoso Laurent, Paulina; Beltrán, Marianela; Hidalgo Tapia, María Cecilia (1996)Calcium binding to triads isolated from rabbit skeletal muscle followed a single hyperbolic function in the pH range 5.5-8.0. Maximal binding was obtained at pH 8.0; decreasing the pH decreased the binding capacity and, ...
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Torres, Rodrigo F.; Hidalgo Tapia, María Cecilia; Kerr, Bredford (Frontiers Media SA, 2017)Mecp2 is a DNA methylation reader that plays a critical role in experience-dependent plasticity. Increasing evidence supports a role for epigenetic modifications in activity-induced gene expression. Hence, candidate genes ...
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Espinosa, Alejandra; Leiva, Aída; Peña, Marisol; Müller, Mariolly; Debandi Cuadra, Aníbal; Hidalgo Tapia, María Cecilia; Carrasco Friz, María Angélica; Jaimovich Pérez, Enrique (WILEY-LISS, DIV JOHN WILEY & SONS INC, 2006-11)Controlled generation of reactive oxygen species (ROS) may contribute to physiological intracellular signaling events. We determined ROS generation in primary cultures of rat skeletal muscle after field stimulation (4001-ms ...
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Plaza Briceño, Wladimir; Estay, Sebastián; Fuente Ortega, Erwin de la; Gutiérrez, Camilo; Sánchez Vergara, Gina; Hidalgo Tapia, María Cecilia; Chávez, Andrés; Haeger, Paola (Mary Ann Liebert, 2020)Aims: Pre- and/or early postnatal ethanol exposure (prenatal alcohol exposure [PAE]) impairs synaptic plasticity as well as memory formation, but the mechanisms underlying these effects remain unclear. Both long-term ...
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Espinosa, Alejandra; García, Alejandra; Härtel, Steffen; Hidalgo Tapia, María Cecilia; Jaimovich Pérez, Enrique (2009)Skeletal muscle is one of the main physiological targets of insulin, a hormone that triggers a complex signaling cascade and that enhances the production of reactive oxygen species (ROS) in different cell types. ROS, ...
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Carrasco, María Angélica; Sierralta, Jimena; Hidalgo Tapia, María Cecilia (1993)Highly purified triads and transverse tubules, as well as a soluble fraction isolated from frog skeletal muscle, hydrolyze exogenous phosphatidylinositol 4,5-bisphosphate forming inositol 1,4,5-trisphosphate with maximal ...
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Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina; Rodriguez, Patricio H. (Biophysical Society, 1996)Calsequestrin, a high-capacity, intermediate-affinity, calcium-binding protein present in the lumen of sarcoplasmic reticulum, undergoes extensive calcium-induced conformational changes at neutral pH that cause distinct ...
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Hidalgo Tapia, María Cecilia; Carrasco, M. Angélica (2011)Calcium ion is a highly versatile cellular messenger. Calcium signals-defined as transient increments in intracellular-free calcium concentration-elicit a multiplicity of responses that depend on cell type and signal ...