Now showing items 1-20 of 27

    • Núñez Vergara, Luis; Donoso, G.; Roman, A.; Squella Serrano, Juan (1988)
      The apparent permeation rate constants and amount of ranitidine transferred in 1 h were measured through everted rat intestine using a perfusion apparatus. The effects of pH and 5% or 10% ethanol on the apparent permeation ...
    • Álvarez Lueje, Alejandro; Núñez Vergara, Luis; Vicuna,; Squella Serrano, Juan (1996)
      The electrochemical oxidation of acyclovir at different pH and concentrations using both differential pulse and cyclic voltammetry was studied. Acyclovir exhibits one differential pulse voltammetric peak at the glassy ...
    • Squella Serrano, Juan; Silva,; Núñez Vergara, Luis (1981)
      The hydrolysis of flucloxacillin at pH 4.9 yields a degradation product which is polarographically oxidizable. This derivative has not been identified, but would seem to contain a thiol group. It gives a diffusion-controlled ...
    • Squella Serrano, Juan; Mosre, J.; Blázquez, M.; Núñez Vergara, Luis (1991)
      Electrochemical studies on nitrendipine using mixed aqueous/dimethylformamide (DMF) solvent have allowed us to generate the one-electron reduction product, the nitro radical anion, RNO.-2. The voltammetric technique has ...
    • Squella Serrano, Juan; Borges, Y.; Bobadilla, L.; Núñez Vergara, Luis (1990)
      A new differential pulse polarographic method for the determination of buspirone pharmaceutical formulations is proposed. The method is based on the CN bond electroactivity of buspirone pirimidinic ring. Recovery study ...
    • Squella Serrano, Juan; Iribarren, Anny E.; Sturm, Juan C.; Núñez Vergara, Luis (1999)
      Lacidipine is an antihypertensive drug that is oxidizable at the glassy carbon electrode. The voltammetric oxidation of lacidipine in aqueous-alcoholic solutions (70 + 30) produces a well-defined voltammetric peak when ...
    • Núñez Vergara, Luis; Squella Serrano, Juan (1983)
      The a.c polarographic method has been applied in the study of the glutathione-ampicillin interaction at pH 7.4 and 37°C. Ampicillin shifted the peak potentials of glutathione to less negative values. A linear relation was ...
    • Squella Serrano, Juan; Cassels Niven, Bruce; Arata, M.; Bavestrello, M. P.; Núñez Vergara, Luis (Pergamon Press Ltd., 1993-03-23)
      Four amphetamine derivatives bearing a methylenedioxy group at positions 3 and 4 of the benzene ring and differing in their substitution at C(6) were studied by differential pulse voltammetry in aqueous media. These ...
    • Squella Serrano, Juan; Cassels Niven, Bruce; Arata, M.; Bavestrello, M. P.; Núñez Vergara, Luis (1993)
      Four amphetamine derivatives bearing a methylenedioxy group at positions 3 and 4 of the benzene ring and differing in their substitution at C(6) were studied by differential pulse voltammetry in aqueous media. These ...
    • Sturm, J. C.; Núñez Vergara, Luis; Squella Serrano, Juan (1992)
      Electrochemical reduction of nicergoline was studied at different pH and concentrations using differential pulse polarography and linear sweep voltammetry. Both techniques reveal that the reduction process occurs with ...
    • Squella Serrano, Juan; Berguecio, María; Hernández, A.; Cassels Niven, Bruce; Núñez Vergara, Luis (Elsevier , Science Ltd., 1991-11-26)
      A set of 2,5-dimethoxyamphetarnines differing in their substitution at C4 was studied by differential pulse voltammetry and linear scan cyclic voltammetry in aqueous media. These experiments showed a single oxydation ...
    • Squella Serrano, Juan; Sturm, J. C.; Weiss López, Boris; Bontá, M.; Núñez Vergara, Luis (Elsevier Sequoia SA, 1999)
      The electrochemical reduction of a series of β-nitrostyrene and β-methyl-β-nitrostyrene derivatives by tast and differential pulse polarography and cyclic voltammetry over a wide pH range was studied. The reduction potentials ...
    • De Souza, Antonio A.; De Moura, Maria Aline B.F.; De Abreu, Fabiane C.; Goulart, Marília O. F.; Da Silva, Eufrânio N.; Pinto, Antonio V.; Ferreira, Vitor F.; Moscoso Cabello, Raúl Andrés; Núñez Vergara, Luis; Squella Serrano, Juan (2010)
      The electrochemistry of 2,2-dimethyl-(3H)-3-(N-3'-nitrophenylamino) naphtho[1,2-b]furan-4,5-dione ([Q]-PhNO2), on mercury was investigated. The first peak is consistent with a quasi-reversible one-electron reduction of the ...
    • Núñez Vergara, Luis; García, F.; Domínguez, M. M.; Fuente Urrutia, Julio de la; Squella Serrano, Juan (1995)
    • Squella Serrano, Juan; Núñez Vergara, Luis; Barría, J.; Echegaray, E. (1983)
      The interaction of glutathione with cloxacillin was investigated by a new a.c. polarographic procedure. The theoretical treatment used to describe the interaction is strongly consistent with the experimental results. The ...
    • Squella Serrano, Juan; Borges, Y.; Celedon, C.; Peredo, P.; Núñez Vergara, Luis (1991)
      A new differential pulse polarographic method is proposed for the determination of nicardipine, based on the electroactivity of the nitroaromatic group of the molecule. The proposed method is applied in the determination ...
    • Núñez Vergara, Luis; Bollo Dragnic, Soledad; Alvarez, A. F.; Squella Serrano, Juan; Blazquez, M. (1993)
      Voltammetric studies of nimodipine using a mixed aqueous dimethylformamide (DMF) solvent have allowed us to generate the one-electron reduction product, the nitro radical anion RNO2 .. The cyclic voltammetry technique has ...
    • Núñez Vergara, Luis; Matus, C.; Álvarez Lueje, Alejandro; Cassels Niven, Bruce; Squella Serrano, Juan (VCH Publishers. Inc., 1994)
      The cyclic voltammetric characteristics of two nitroamphetamine derivatives (2-nitro-4,5dimethoxyamphetamine and 2-nitro-4,5-methylenedioxyamphetamine) have been investigated in different media. In mixed media (aqueous ...
    • Núñez Vergara, Luis; Matus, C.; Álvarez Lueje, Alejandro; Cassels Niven, Bruce; Squella Serrano, Juan (1994)
      The cyclic voltammetric characteristics of two nitroamphetamine derivatives (2‐nitro‐4,5‐dimethoxyamphetamine and 2‐nitro‐4,5‐methylenedioxyamphetamine) have been investigated in different media. In mixed media (aqueous ...
    • Núñez Vergara, Luis; Sunkel, Carlos; Squella Serrano, Juan (1994)
      The photodecomposition of new 1,4‐dihydropyridine, furnidipine (CRE‐319); 2,6‐dimethyl‐4‐(2‐nitrophenyl)‐1,4‐dihydropy‐ridine‐3,5‐dicarboxylic acid 3‐tetrahydrofurfuryl (5‐methyl diester) was studied by voltammetric, UV‐vis ...