Browsing by Title Artículos de revistas

Now showing items 1237-1256 of 2801

    • Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat 
      Sapag Muñoz de la Peña, Amalia; Irarrázaval Aguilera, Thergiorg; Lobos González, Lorena; Muñoz Brauning, Carlos; Quintanilla González, María Elena; Tampier de Jong, Lutske (Nature Publishing Group, 2016)
      Ribozyme genes were designed to reduce voluntary alcohol drinking in a rat model of alcohol dependence. Acetaldehyde generated from alcohol in the liver is metabolized by the mitochondrial aldehyde dehydrogenase (ALDH2) ...
    • Halogenated monoterpenes of the red alga Shottera nicaensis 
      Cancino Rivera, Patricio Antonio; Astudillo, Luis; Rovirosa, Juana; San Martín Barrientos, Aurelio (1987)
    • Hantzsch dihydropyridines: Privileged structures for the formation of well-defined gold nanostars 
      Zapata Urzúa, Claudio; Pérez Ortiz, Magdalena; Acosta, Gerardo A.; Mendoza, Joan; Yedra, Lluis; Estradé, Sonia; Álvarez Lueje, Alejandro; Núñez Vergara, Luis; Albericio, Fernando; Lavilla, Rodolfo; Kogan Bocian, Marcelo (Elsevier, 2015)
      Anisotropic and branched gold nanoparticles have great potential in optical, chemical and biomedical applications. However their syntheses involve multi-step protocols and the use of cytotoxic agents. Here, we report a ...
    • Harmonic Analysis of Radon Filtrations for Sn and GLn(q) 
      Yañez Valdés, María Francisca (2014)
      We present a unified approach to the study of Radon transforms related to symmetric groups and to general linear groups GLn(q), regarded as q−analogues of the former. In both cases, we define a sequence of generalized ...
    • HEADSPACE-MASS SPECTROMETRY WITH ALTERNATIVE CHROMATOGRAPHIC SEPARATION USING A COLUMN SWITCHING SYSTEM FOR ... 
      Toledo, Carla; Enríquez, Pedro; Garrido, Mariano; Fernández-Band, Beatríz; Richter Duk, Pablo (TAYLOR & FRANCIS INC, 2010)
      A headspace-mass spectrometry with alternative chromatographic separation using a column switching system was developed for the screening and confirmation of BTEX and styrene in comestible oils. According to the position ...
    • Health-promoting activities of edible seaweed extracts from Chilean coasts: assessment of antioxidant, ... 
      García, Vivian; Uribe, Elsa; Vega Gálvez, Antonio; Delporte Vergara, Carla; Valenzuela Barra, Gabriela; López, Jéssica; Pasten, Alexis (Sociedad Chilena de Nutrición, 2020)
      The aim of this study was to evaluate the antioxidant, antidiabetic, anti-inflammatory and antimicrobial activities of three edible seaweed extracts from Chilean coasts: Pyropia orbicularis, Ulva spp, and Durvillaea ...
    • The heat released during catalytic turnover enhances the diffusion of an enzyme 
      Riedel, Clement; Gabizon, Ronen; Wilson Moya, Christian; Hamadani, Kambiz; Tsekouras, Konstantinos; Marqusee, Susan; Presse, Steve; Bustamante, Carlos (Macmillan, 2015)
      Recent studies have shown that the diffusivity of enzymes increases in a substrate-dependent manner during catalysis1,2. Although this observation has been reported and characterized for several different systems3–10, ...
    • Heavy metals in rivers and soils of central Chile 
      Schalscha B., Eduardo; Ahumada Torres, Aída Inés de Lourdes (PERGAMON-ELSEVIER SCIENCE LTD, 1998)
      Industrial and domestic waste waters in Chile are discharged without previous treatment into rivers and other inland waters which are used to irrigate agricultural lands. The present study reports on results obtained when ...
    • Helicobacter pylori and epigenetic mechanisms underlying gastric carcinogenesis 
      Valenzuela, Manuel A.; Canales, Jimena; Corvalán, Alejandro H.; Quest, Andrew F. G. (Baishideng Publishing Group Inc., 2015)
      The sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". This cascade is a dynamic process that includes lesions, such as atrophic gastritis, ...
    • The hemolytic effect of Salmonella typhi T y 2 porins 
      Calderón, Inés; Lobos, S.; Mora, Guido C. (Springer-Verlag, 1984)
      Two outer membrane proteins of Salmonella typhi T y 2 were extensively co-purified. According to their migration in dodecyl sulfate/polyacrylamide gel electrophoresis and solubility characteristics, these proteins are ...
    • Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression 
      Olivares Silva, Francisco Javier; Landaeta, Rodolfo; Aránguiz, Pablo; Bolivar, Samir; Humeres Martínez, Claudio; Anfossi, Renatto; Vivar Sánchez, Raúl; Boza Fuentes, Pía; Muñoz Jofré, Claudia; Pardo Jiménez, Viviana Gladys; Peiro, Concepción; Sánchez Ferrer, Carlos; Díaz Araya, Guillermo (Elsevier, 2018)
      Cardiac fibroblasts (CF) act as sentinel cells responding to chemokines, cytokines and growth factors released in cardiac tissue in cardiac injury events, such as myocardial infarction (MI). Cardiac injury involves the ...
    • Hepcidin inhibits apical iron uptake in intestinal cells 
      Mena, Natalia P.; Esparza, Andrés; Tapia, Victoria; Valdés, Pamela; Núñez González, Marco (2007)
      Hepcidin (Hepc) is considered a key mediator in iron trafficking. Although the mechanism of Hepc action in macrophages is fairly well established, much less is known about its action in intestinal cells, one of the main ...
    • Herbal extracts differentially inhibit oxidative effects caused by the biotransformation of nifurtimox, ... 
      Letelier, María E.; Iturra Montecinos, Pablo; Gallardo Garrido, Carlos (Universidad de Santiago de Chile, 2017)
      Inflammation is a cellular defensive mechanism associated to oxidative stress. The administration of nitrofurantoin, nifurtimox and acetaminophen generates oxidative stress by their biotransformation through CYP450 system. ...
    • HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol ... 
      Paredes, Felipe; Parra, Valentina; Torrealba, Natalia; Navarro Márquez, Mario F.; Gatica, Damián; Bravo Sagua, Roberto; Troncoso, Rodrigo; Pennanen, Christian; Quiroga, Clara; Chiong Lay, Mario; Caesar, Christa; Taylor, W. Robert; Molgó, Jordi; San Martín, Alejandra; Jaimovich Pérez, Enrique; Lavandero González, Sergio (Elsevier, 2016)
      Homocysteine-inducible, endoplasmic reticulum (ER) stress-inducible, ubiquitin-like domain member 1 (HERPUD1), an ER resident protein, is upregulated in response to ER stress and Ca2(+) homeostasis deregulation. HERPUD1 ...
    • Herpudl impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt ... 
      Navarro Márquez, Mario F.; Torrealba, Natalia; Troncoso, Rodrigo; Vásquez Trincado, César; Rodríguez, Marcelo; Morales, Pablo E.; Villalobos, Elisa; Eura, Yuka; García Nannig, Lorena; Chiong Lay, Mario; Klip, Amira; Jaimovich Pérez, Enrique; Kokame, Koichi; Lavandero González, Sergio (Elsevier, 2018)
      Skeletal muscle plays a central role in insulin-controlled glucose homeostasis. The molecular mechanisms related to insulin resistance in this tissue are incompletely understood. Herpud1 is an endoplasmic reticulum membrane ...
    • Heteroarylnitrones as Drugs for Neurodegenerative Diseases: Synthesis, Neuroprotective Properties, and Free ... 
      Porcal, Williams; Hernández, Paola; González, Mercedes; Ferreira, Ana; Olea Azar, Claudio; Cerecetto, Hugo; Castro, Ana (American Chemical Society, 2008-09)
      New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective agents on a human neuroblastoma (SH-SY5Y) cells model. They inhibited at low micromolar concentrations the oxidative ...
    • Heterocyclic curcumin derivatives of pharmacological interest: Recent progress 
      Martínez Cifuentes, Maximiliano; Weiss López, Boris; Santos, Leonardo S.; Araya Maturana, Ramiro (Bentham Science Publishers B.V., 2015)
      © 2015, Bentham Science Publishers. Curcumin, a natural yellow polyphenol, is isolated from the herb Curcuma longa L. (turmeric), a member of the ginger family. It has been extensively studied due to their multiple ...
    • Heterocyclization of 3-deoxy-D-erythro-hexos-2-ulose-1,2-bis(thiosemicarbazone). Crystal structure of the ... 
      Martins Alho, Miriam A.; Baggio, Ricardo; Garland, María Teresa; D'Accorso, Norma B.; Varela, Oscar (2002)
      Both thiosemicarbazone groups of the derivative 1 of 3-deoxy-D-erythro-hexos-2-ulose underwent, on acetylation, a heterocyclization process to give (5R,5′R)-2,2′-diacetamido-4,4′-di-N-acetyl-5′-(1- deoxy-2,3,4-tri-O-acet ...
    • Heterologous expression of an α‑amylase inhibitor from common bean (Phaseolus vulgaris) in Kluyveromyces ... 
      Brain Isasi, Stephanie; Álvarez Lueje, Alejandro; Higgins, Thomas Joseph V. (BioMed Central, 2017-06-15)
      Background: Phaseolamin or alpha-amylase inhibitor 1 (alpha AI) is a glycoprotein from common beans (Phaseolus vulgaris L.) that inhibits some insect and mammalian alpha-amylases. Several clinical studies support the ...
    • Heterologous microsatellite-based genetic diversity in blue mussel (Mytilus chilensis) and differentiation ... 
      Larraín Barth, María Angélica; Díaz, Nelson F.; Lamas, Carmen; Uribe, Carla; Jilberto, Felipe; Araneda Tolosa, Cristian (PUCV, 2015)
      Mussels (Mytilus spp.) are one of the most cultivated and commercialized bivalves in southern Chile; culture is currently supplied almost entirely from wild-caught seed obtained from relatively few collection centers. The ...