Now showing items 2489-2508 of 2801

    • Méndez, Diego; Urra Faúndez, Félix; Millas Vargas, Juan Pablo; Alarcón, Marcelo; Rodríguez Lavado, Julio; Palomo, Iván; Trostchansky, Andrés; Araya Maturana, Ramiro; Fuentes, Eduardo (Elsevier, 2020)
      Cardiovascular diseases are the leading cause of death in the world. Platelets have a major role in cardiovascular events as they bind to the damaged endothelium activating and forming thrombi. Although some hydroquinone ...
    • Pessoa Mahana, Hernán; Acevedo Ramos, Armando Rodrigo; Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa, D. (TAYLOR & FRANCIS INC, 2007)
      New benzothiophene arylpiperazine derivatives 8 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by treating N-[2-(chloromethyl)phenyl] ...
    • Quiroga Campano, Cinthia del Rosario; Gómez Machuca, Horacio Exequiel; Moris, S.; Jara, P.; Fuente, Julio de la; Pessoa Mahana, Hernán; Jullian Matthaei, Carolina; Saitz, C. (Elsevier, 2017)
      A new calix[4]arene thiourea derivative bearing a benzothiazolyl moiety (L) was synthetized and characterized by single crystal X-ray, NMR and ESI-TOF. The binding ability of the bifunctional receptor towards several ions ...
    • Torres Pinedo, Antonio; Santoyo González, Francisco; Saitz Barría, Claudio (GEORG THIEME VERLAG, 1999-12)
      The effective synthesis of a variety of bisthiourea-bridged calix[4]arenes substituted by carbohydrates units (D-glucose, D-mannose, D-galactose and lactose) at the narrow rim by reaction of bis(aminoethoxy)calix[4]arene ...
    • Saitz Barría, Claudio; Fuente, J. de la; Jullian Matthaei, Carolina; Pessoa Mahana, Hernán; Olea, Carolina (SCIENCE REVIEWS LTD, 2008-06)
      A novel series of calix[4]arenes bearing benzothiazole, benzoxazole, and benzoimidazole groups were obtained by the reaction of the corresponding 2-mercaptoheterocycle with 5,11,17,23-tetra-tert-butyl-25,27-bis[2-(chloroacetamido) ...
    • Pessoa Mahana, Hernán; González Lira, Christian Guillermo; Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa, D. (SOC CHILENA QUIMICA, 2009-06)
      New benzothiophene arylpiperazine derivatives 7 (a-1) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by reaction of 1-(4-aminophenyl)-4-[(4 ...
    • Dovale Rosabal, Gretel; Rodríguez Melis, Alicia; Espinosa Escalona, Berta Alejandra; Barriga Pinto, Gonzalo Andrés; Aubourg Martín, Santiago Pedro (MDPI, 2021)
      There is consistent evidence that long-chain polyunsaturated fatty acids (LCPUFA) belonging to the n-3 series, i.e., eicosapentaenoic (20:5n-3, EPA) and docosahexaenoic (22:6n-3, DHA) acids, decrease the risk of heart, ...
    • Aguilar Bolados, Héctor; Contreras Cid, Ahirton; Yazdani-Pedram Zobeiri, Mehrdad; Acosta Villavicencio, Gabriela; Flores Carrasco, Marcos; Fuentealba, Pablo; Neira Carrillo, Andrónico; Verdejo, Raquel; López Manchado, Miguel (Elsevier, 2018-08-15)
      The fluorination of two types of graphene oxides conducted by an easy and scalable deoxyfluorination reaction is reported. This reaction was carried out using diethylaminodifluorosulfinium tetrafluoroborate, a stable ...
    • Tapia, Ricardo A.; Carrasco, Claudia; Ojeda, Scarlet; Salas, Cristian; Valderrama, Jaime A.; Morello Casté, Antonio; Repetto Scaramelli, Yolanda (2002)
      The synthesis of new indazol-4,7-dione derivatives via 1,3-dipolar cycloaddition of diazomethane with 2,3-dimethyl-1,4-benzoquinone (2) and 1,4-naphthoquinone (7) followed by N-alkylation of the pyrazol nitrogen atom of ...
    • Pessoa Mahana, Hernán; Astudillo, C. I.; Araya Maturana, Ramiro (MARCEL DEKKER INC, 2002)
      Syntheses of new morpholinomethylbenzamides 6 bearing both electron-withdrawing and electron-releasing groups at the aromatic ring are described. The strategy involved synthesis of hippuric acid ethyl esters 3, their ...
    • Insuasty, B. A.; Torres, H.; Quiroga, J.; Abonia, R.; Rodríguez, R.; Nogueras, M.; Sánchez, A.; Saitz, C.; Alvarez, S.L.; Zacchino, S.A. (FREUND PUBLISHING HOUSE LTD, 2000)
      The reaction of 4-amino-3-aryl-5-benzylaminopyrazoles (1a,b) with 3-dimethylaminopropiophenones (2) in ethanol with acetic acid gave 1-benzyl-4,6-diaryl-2,3-dihydropyrazolo[3,4-b] [1,4]diazepines (3a-h). The structure ...
    • Santander Gutiérrez, Ingrid Paola; Núñez Vergara, Luis; Squella Serrano, Juan; Navarrete Encina, Patricio (GEORG THIEME VERLAG KG, 2003-12-18)
      The synthesis and characterization of a series of 4-nitrosophenyl-1.4-dihydropyridines derived from the respective nitro compounds of pharmacological interest is described. The complete synthetic pathway is based on the ...
    • Santander Gutierrez, Ingrid Paola; Núñez Vergara, Luis; Squella Serrano, Juan; Navarrete Encina, Patricio (GEORG THIEME VERLAG KG, 2003-12-18)
      The synthesis and characterization of a series of 4-nitrosophenyl-1.4-dihydropyridines derived from the respective nitro compounds of pharmacological interest is described. The complete synthetic pathway is based on the ...
    • Retuert, Jaime; Nuñez, Alicia; Martínez, Francisco; Yazdani-Pedram Zobeiri, Mehrdad (Wiley-VCH Verlag, 1997)
      This work reports the synthesis of a novel polymeric organic-inorganic hybrid. The inorganic component is a silica network obtained by controlled hydrolysis of tetraethyl orthosilicate via sol-gel process and the organic ...
    • Quiroga, Jairo; Hormaza, Angelina; Insuasty, Braulio; Saitz Barría, Claudio; Jullian Matthaei, Carolina; Cañete, Alvaro (HeteroCorporation, 1998)
      A series of pyrazolo[1,5-a]pyrimidin-3-ones 3 was prepared from Meldrum's acid and 5-amino-3-arylpyrazoles 1 by cyclization in nitrobenzene of the corresponding 5-pyrazolylaminomethylene Meldrum's acid derivatives 2. The ...
    • Pilaquinga, Fernanda; Amaguana, Dennis; Morey, Jeroni; Moncada-Basualto, Mauricio; Pozo Martínez, Josué; Olea Azar, Claudio; Fernández, Lenys; Espinoza Montero, Patricio; Jara Negrete, Elisa; Meneses, Lorena; López, Fernanda; Debut, Alexis; Piña, Nieves (MDPI, 2020)
      The search for sensitive and rapid analytical techniques for the determination of natural antioxidants is an area in constant growth due, among other aspects, to the complexity of plant matrices. In this study, silver ...
    • Navarrete Encina, Patricio; Squella Serrano, Juan; Carbajo, J.; Conde, B.; Núñez Vergara, Luis (TAYLOR & FRANCIS INC, 2007)
      A series of C-3,4,5-substituted 2,6-dimethyl-1,4-dihydropyridines ( 1,4-DHPs) with pharmacological properties were prepared by a variation from the classical Hantzsch synthesis. The procedure involves treatment of the ...
    • Romero Parra, Javier; Mella Ralpán, Jaime; Palmieri, Vittoria; Allara, Marco; Torres, María José; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Escobar, Rossy; Faúndez, Mario; Di Marzo, Vincenzo; Pessoa Mahana, Carlos David (Elsevier, 2016)
      Herein we report the design, synthesis, bioinformatic and biological studies of benzimidazole and benzothiophene derivatives as new cannabinoid receptor ligands. To test the hypothesis that the lack of a hydrogen bond ...
    • Parada Aliste, José; Atria Salas, Ana María; Wiese, Guillermo; Rivas, Elizabeth; Corsini, Gino (Soc Chilena Química, 2014)
      The mononuclear cobalt(III) complex derived from 1,10-phenanthroline and maltose ([Co(phen)(2)maltose]Cl-2 center dot 3H(2)O) (1) has been synthesized and characterized in aqueous solution. Its characterization was based ...
    • Insuasty, B.; Torres, H.; Quiroga, J.; Abonia, R.; Rodríguez, R.; Nogueras, M.; López Sánchez, A.; Saitz Barría, Claudio; Alvarez, S. L.; Zacchino, Susana (Sociedad Chilena de Química, 2006)
      The synthesis of a series of new benzimidazo [1,2-c]quinazolines starting from 2-nitrobenzaldehyde and o-phenylendiamine is decsribe. The structure elucidation of the products is based on detailed NMR analysis of experiments ...