Browsing by Author "1a297a98-4876-4a1f-8921-c55a9d1cad9e"

Now showing items 1-6 of 6

    • Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation 
      Silva, Patricio; Soto, Nicolás; Díaz, Jorge; Mendoza, Pablo; Díaz, Natalia; Quest, Andrew F. G.; Torres Gómez, Vicente (Elsevier, 2015)
      The early endosomal protein Rab5 is highly expressed in tumor samples, although a causal relationship between Rab5 expression and cell transformation has not been established. Here, we report the functional effects of ...
    • Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis 
      Silva, Patricio; Mendoza, Pablo; Rivas, Solange; Díaz, Jorge; Moraga, Carolina; Quest, Andrew F. G.; Torres, V. A. (Oncotarget, 2016)
      Hypoxia, a common condition of the tumor microenvironment, is associated with poor patient prognosis, tumor cell migration, invasion and metastasis. Recent evidence suggests that hypoxia alters endosome dynamics in tumor ...
    • Loss of caveolin-1 is associated with a decrease in beta cell death in mice on a high fat diet 
      Lillo Urzúa, Paloma; Núñez Murillo, Olinda; Castro Sepúlveda, Mauricio; Torres Quintana, María Angélica; Lladser Caldera, Álvaro; Quest, Andrew F. G.; Espinoza Robles, Carolina; Llanos Vidal, Paola; Wehinger, Sergio (MDPI, 2020)
      Elevated free fatty acids (FFAs) impair beta cell function and reduce beta cell mass as a consequence of the lipotoxicity that occurs in type 2 diabetes (T2D). We previously reported that the membrane protein caveolin-1 ...
    • MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjögren's syndrome 
      Sung, H. H.; Castro, I.; González, S.; Aguilera, S.; Smorodinsky, N. I.; Quest, Andrew F. G.; Bahamondes, V.; Alliende, C.; Cortés, J.; Molina, C.; Urzúa, U.; Barrera, M. J.; Hermoso Ramello, Marcela; Herrera, L.; Leyton, C.; González, M. J. (Blackwell, 2015)
      ORIGINAL ARTICLEMUC1/SEC and MUC1/Y overexpression is associatedwith inflammation in Sj€ogren’s syndromeHH Sung1,*, I Castro1,*, S Gonz alez2, S Aguilera3, NI Smorodinsky4, AFG Quest1,5, V Bahamondes1,C Alliende1, J Cort ...
    • The Porphyromonas gingivalis O antigen is required for inhibition of apoptosis in gingival epithelial cells ... 
      Soto, Cristopher; Bugueño Valdebenito, Isaac; Hoare Teuche, Anilei; González, S.; Vengas Díaz, Darna; Melgar Rodríguez, Samanta; Vernal Astudillo, Rolando; Gamonal Aravena, Jorge Antonio; Quest, Andrew F. G.; Pérez Donoso, José; Bravo Rodríguez, Denisse (Wiley Blackwell, 2016)
      Background and ObjectivePorphyromonas gingivalis infection induces apoptosis inhibition in gingival epithelial cells; however, it is not fully understood which bacterial effectors are involved in this process. The aim of ...
    • The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells 
      Rivas, Solange; Silva, Patricio; Reyes Rojas, Montserrat; Sepúlveda, Hugo; Solano, Luis; Acuña, Juan; Guerrero, Marisol; Varas Godoy, Manuel; Quest, Andrew F. G.; Montecino, Martín; Torres Gómez, Vicente (Nature, 2020)
      Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and ...