Now showing items 21-40 of 55

    • Vernal Astudillo, Rolando; Dutzan Muñoz, Nicolás; Hernández Ríos, Emma; Chandía Espinosa, Sabrita; Puente Piccardo, Javier; León Berríos, Rubén; García, Leyre; Valle, Ignacio del; Silva, Augusto; Gamonal Aravena, Jorge Antonio (American Academy of Periodontology, 2006-10)
      Background: Chronic periodontitis is an infectious disease characterized by alveolar bone destruction and teeth loss. Receptor activator of nuclear factor-kappa B ligand (RANKL) is an osteoclastogenic cytokine, a central ...
    • Cavalla, Franco; Reyes, Montserrat; Vernal Astudillo, Rolando; Álvarez, Carla; Paredes, Rodolfo; García Sesnich, Jocelyn; Infante, Magdalena; Fariña, Valeska; Barrón, Ignacio; Hernández, Marcela (2013)
      INTRODUCTION: CXC ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) is a pleiotropic chemokine that regulates the influx of a wide range of leukocytes. The aim of this study was to characterize CXCL12/SDF-1 in apical ...
    • Cavalla, Franco; Reyes Rojas, Montserrat de los Ángeles; Vernal Astudillo, Rolando; Álvarez, Carla; Paredes, Rodolfo; García Sesnich, Jocelyn; Infante, Magdalena; Fariña, Valeska; Barrón, Ignacio; Hernández Ríos, Marcela (American Association of Endodontists, 2013)
      Introduction: CXC ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) is a pleiotropic chemokine that regulates the influx of a wide range of leukocytes. The aim of this study was to characterize CXCL12/SDF-1 in apical lesions ...
    • Hernández Ríos, Emma; Dutzan Muñoz, Nicolás; García Sesnich, Jocelyn; Abusleme Ramos, Loreto Andrea; Dezerega Piwonka, Andrea; Silva Steffens, Nora; González Bergas, Fermín; Vernal Astudillo, Rolando; Sorsa, T.; Gamonal Aravena, Jorge Antonio (Sage, 2011-10)
      Periodontitis is an infection characterized by the occurrence of supporting tissue destruction with an episodic nature. Disease progression is often determined by the loss of attachment level or alveolar bone, and sequential ...
    • Monasterio, Gustavo; Guevara, José; Ibarra, Juan; Castillo, Francisca; Díaz Zúñiga, Jaime; Alvarez, Carla; Cafferata, Emilio; Vernal Astudillo, Rolando (Springer Verlag, 2018)
      Objectives Periodontitis is a chronic inflammatory disease characterized by tooth-supporting tissue destruction, which is elicited by the host’s immune response triggered against periodonto-pathogen bacteria. During ...
    • Díaz Zúñiga, Jaime; Melgar Rodríguez, Samanta; Rojas, L.; Alvarez, C.; Monasterio, G.; Carvajal Pavez, Paola; Vernal Astudillo, Rolando (Wiley, 2017)
      Background and ObjectiveTwo new T-helper (Th) phenotypes have been recently described and named Th9 and Th22 lymphocytes; however, their role in the pathogenesis of periodontitis remains unclear. This study was aimed to ...
    • Dutzan Muñoz, Nicolás; Vernal Astudillo, Rolando; Vaque, Jose; García Sesnich, Jocelyn; Hernandez, Marcela; Abusleme, Loreto; Dezerega, Andrea; Gutkind, J.; Gamonal Aravena, Jorge Antonio (2012)
      Background: Interleukin-21 (IL-21) controls the differentiation of T-helper Th17 cells and induces the production of IL-17 in this T-cell subtype. The aim of this study is to determine the relative expression of IL-21 ...
    • Cafferata, Emilio; Terraza Aguirre, Claudia; Barrera, Romina; Faúndez, Nicolás; González, Nicolás; Rojas, Carolina; Melgar Rodríguez, Samanta; Hernández, Marcela; Carvajal, Paola; Cortez, Cristian; González, Fermín; Covarrubias, Cristian; Vernal Astudillo, Rolando (Wiley, 2020)
      Aim T lymphocytes play a central role during the pathogenesis of periodontitis, and the imbalance between the pathogenic T-helper type 17 (Th17) and protective T-regulatory (Treg) lymphocytes determines the tooth-supporting ...
    • Vernal Astudillo, Rolando; Chaparro, Alejandra; Graumann, Rebecca; Puente, Javier; Valenzuela, Maria Antonieta; Gamonal Aravena, Jorge Antonio (2004)
      Background: Receptor activator of nuclear factor κB ligand (RANK-L) is a cytokine involved in the regulation of osteoclastogenesis in bone remodeling and inflammatory osteolysis. One of the major causes of tooth loss in ...
    • Dutzan Muñoz, Nicolás; Vernal Astudillo, Rolando; Hernández Ríos, Emma; Dezerega Piwonka, Andrea; Rivera Escobar, Oriana; Silva Steffens, Nora; Aguillón Gutiérrez, Juan Carlos; Puente Piccardo, Javier; Pozo, Patricia; Gamonal Aravena, Jorge Antonio (2009-02)
      Background: Periodontitis is an infection with an episodic pattern of tissue-support destruction. During the generation of a primary CD4+ T helper 1 (Th1) response, interferon-gamma (IFN-g) acts as a positive regulator ...
    • Vernal Astudillo, Rolando; Dutzan Muñoz, Nicolás; Chaparro, Alejandra; Puente Piccardo, Javier; Valenzuela, María Antonieta; Gamonal Aravena, Jorge Antonio (BLACKWELL MUNKSGAARD, 2005-04)
      Background and Aims: Interleukin-17 (IL-17) is a T-cell-derived cytokine that may play an important role in the initiation or maintenance of the pro-inflammatory response and has recently been found to stimulate osteoclastic ...
    • Dutzan Muñoz, Nicolás; Rivas, Catalina; García Sesnich, Jocelyn; Henríquez, Leslie; Rivera Escobar, Oriana; Dezerega Piwonka, Andrea; Hernández Ríos, Emma; Silva Steffens, Nora; Aguillón Gutiérrez, Juan Carlos; Puente Piccardo, Javier; Vernal Astudillo, Rolando; Gamonal Aravena, Jorge Antonio (American Academy of Periodontology, 2011-10)
      BACKGROUND: A growing body of evidence suggested that interleukin (IL)-21 enhances the effector phase during T-cell responses. The aim of our study is to determine the levels of IL-21 in periodontal sites from patients ...
    • Veloso Matta, Pablo; Fernández, Alejandra; Terraza, Claudia; Álvarez Rivas, Carla; Vernal Astudillo, Rolando; Escobar Álvarez, Alejandro; Hernández Ríos, Emma (Springer, 2020)
      Objectives To explore the macrophage profiles in symptomatic and asymptomatic forms of AP through phenotypic and functional analyses. Material and methods Cross-sectional study. Apical tissue/lesion samples were collected ...
    • Hernández Ríos, Emma; Valenzuela, María Antonieta; López Otin, Carlos; Alvarez, Jesús; López, José Manuel; Vernal Astudillo, Rolando; Gamonal Aravena, Jorge Antonio (American Academy of Periodontology, 2006-11)
      Background: Matrix metalloproteinases (MMPs) participate in extracellular matrix degradation in physiological and pathological conditions. The available evidence suggests that MMP-13 plays a significant role in both the ...
    • Ortiz, María Carolina; Lefimil Puente, Claudia; Rodas, Paula I.; Vernal Astudillo, Rolando; López, Mercedes; Acuña Castillo, Claudio; Imarai, Mónica; Escobar, Alejandro (Public Library Science, 2015)
      Current data suggest that Neisseria gonorrhoeae is able to suppress the protective immune response at different levels, such as B and T lymphocytes and antigen-presenting cells. The present report is focused on gonococcus ...
    • Monasterio, Gustavo; Ormeño Castillo, Francisca; Astorga, Jéssica; Hoare Teuche, Anilei; Terraza, Claudia; Cafferata, Emilio A.; Villablanca, Eduardo J.; Vernal Astudillo, Rolando Marcelo (Frontiers Media, 2020)
      Aggregatibacter actinomycetemcomitans is a Gram-negative oral bacterium with high immunostimulatory and pathogenic potential involved in the onset and progression of periodontitis, a chronic disease characterized by aberrant ...
    • Dutzan Muñoz, Nicolás; Gamonal Aravena, Jorge Antonio; Silva, Augusto; Sanz, Mariano; Vernal Astudillo, Rolando (John Wiley, 2009)
      Aim: T regulatory (Treg) cells have been detected in periodontitis lesions, and forkhead box P3 (Foxp3) expression has been negatively correlated to receptor activator of nuclear factor-k B ligand (RANKL). The aim of ...
    • Dutzan Muñoz, Nicolás; Gamonal Aravena, Jorge Antonio; Silva, Augusto; Sanz, Mariano; Vernal Astudillo, Rolando (John Wiley & Sons, 2009-05)
      Aim: T regulatory (Treg) cells have been detected in periodontitis lesions, and forkhead box P3 (Foxp3) expression has been negatively correlated to receptor activator of nuclear factor-κ B ligand (RANKL). The aim of this ...
    • Dutzan Muñoz, Nicolás; Gamonal Aravena, Jorge Antonio; Silva, Augusto; Sanz, Mariano; Vernal Astudillo, Rolando (2009)
      Aim: T regulatory (Treg) cells have been detected in periodontitis lesions, and forkhead box P3 (Foxp3) expression has been negatively correlated to receptor activator of nuclear factor-κ B ligand (RANKL). The aim of this ...
    • Cafferata Chea, Emilio; Monasterio Ocares, Gustavo; Castillo Franzoy, Francisca; Carvajal Pavez, Paola; Flores Sepúlveda, Guillermo; Díaz Guzmán, Walter; Fuentes del Campo, Aler; Vernal Astudillo, Rolando (Wiley, 2020)
      Objective This study aimed to determine the expression of distinct matrix metalloproteinases, cytokines, and bone resorptive factors in temporomandibular joint osteoarthritis (TMJ-OA) patients and their association with ...