Browsing by Author "Jämsen, Eemeli"

Now showing items 1-3 of 3

    • Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene ... 
      Nabeshima, Akira; Pajarinen, Jukka; hua Lin, Tzu; Jiang, Xinyi; Gibon, Emmanuel; Córdova, Luis; Loi, Florence; Lu, Laura; Jämsen, Eemeli; Egashira, Kensuke; Yang, Fan; Yao, Zhenyu; Goodman, Stuart (Elsevier Ltd, 2017)
      Wear particle-induced osteolysis limits the long-term survivorship of total joint replacement (TJR). Monocyte/macrophages are the key cells of this adverse reaction. Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) is the ...
    • Orthopaedic wear particle-induced bone loss and exogenous macrophage infiltration is mitigated by local ... 
      Lin, Tzuhua; Pajarinen, Jukka; Nabeshima, Akira; Córdova, Luis; Loi, Florence; Gibon, Emmanuel; Lu, Laura; Nathan, Karthik; Jämsen, Eemeli; Yao, Zhenyu; Goodman, Stuart (John Wiley and Sons Inc., 2017)
      Excessive production of wear particles from total joint replacements (TJRs) induces chronic inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This inflammation and bone remodeling ...
    • Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin ... 
      Lu, Laura; Loi, Florence; Nathan, Karthik; Lin, Tzu; Pajarinen, Jukka; Gibon, Emmanuel; Nabeshima, Akira; Cordova, Luis; Jämsen, Eemeli; Yao, Zhenyu; Goodman, Stuart (John Wiley and Sons Inc., 2017)
      Bone fractures are among the most common orthopaedic problems that affect individuals of all ages. Immediately after injury, activated macrophages dynamically contribute to and regulate an acute inflammatory response that ...