Now showing items 1-13 of 13

    • Hoare, Anilei; Wang, Hui; Meethil, Archana; Abusleme Ramos, Loreto; Hong, Bo-Young; Moutsopoulos, Niki M.; Marsh, Philip D.; Hajishengallis, George; Díaz, Patricia I. (Springernature, 2020)
      Recent studies describe in detail the shifts in composition of human-associated polymicrobial communities from health to disease. However, the specific processes that drive the colonization and overgrowth of pathogens ...
    • Cavalla Ruiz, Ian Franco; Biguetti, Claudia C.; Dionisio, Thiago J.; Azevedo, Michelle C. S.; Martins, Walter, Jr.; Santos, Carlos F.; Trombone, Ana Paula F.; Silva, Renato M.; Letra, Ariadne; Garlet, Gustavo P. (Elsevier, 2018)
      Chronic and aggressive periodontitis are infectious diseases characterized by the irreversible destruction of periodontal tissues, which is mediated by the host inflammatory immune response triggered by periodontal infection. ...
    • Abusleme Ramos, Loreto Andrea; Morandini, Ana Carolina; Hashizume Takizawa, Tomomi; Sahingur, Sinem Esra (Frontiers Media SA, 2021)
    • Sansores España, Luis; Morales Lara, Francisca; Arriola Pacheco, Fabio; Astorga, Jessica; Paula Lima, Andrea; Carrillo Ávila, Arelly; Melgar Rodríguez, Samanta; Martínez Aguilar, Víctor; Díaz Zúñiga, Jaime (Universidad Costa Rica, Facultad Odontología, 2022)
      Periodontitis is a low-grade inflammatory disease caused by a subgingival dysbiotic microbiota. Multiple studies have determined the higher prevalence of tooth loss and poor oral hygiene in patients with Alzheimer's disease ...
    • Biguetti, Claudia Cristina; Cavalla, Franco; Silveira, Elcia Varize; Tabanez, André Petenuci; Francisconi, Carolina Favaro; Taga, Rumio; Campanelli, Ana Paula; Trombone, Ana Paula Favaro; Rodrigues, Danieli C.; Garlet, Gustavo Pompermaier (Frontiers Media, 2019)
      The release of the prototypic DAMP High Mobility Group Box 1 (HMGB1) into extracellular environment and its binding to the Receptor for Advanced Glycation End Products (RAGE) has been described to trigger sterile inflammation ...
    • Loi, Florence; Córdova Jara, Luis; Pajarinen, Jukka; Lin, Tzu-hua; Yao, Zhenyu; Goodman, Stuart B. (Elsevier, 2016)
      The reconstitution of lost bone is a subject that is germane to many orthopedic conditions including fractures and non-unions, infection, inflammatory arthritis, osteoporosis, osteonecrosis, metabolic bone disease, tumors, ...
    • Metcalfe, Sarah; Anselmi, Natalie; Escobar Álvarez, Alejandro Felipe; Visser, Michelle B.; Kay, Jason G. (Frontiers Media, 2022)
      The oral cavity is a complex environment constantly exposed to antigens from food and the oral microbiota. Innate immune cells play an essential role in maintaining health and homeostasis in the oral environment. However, ...
    • Favaro Trombone, Ana Paula; Cavalla Ruiz, Ian Franco; Varize Silveira, Elcia María; Andreo, Camile Bermejo; Francisconi, Carolina Favaro; Fonseca, Angélica Cristina; Letra, Ariadne; Silva, Renato Menezes; Garlet, Gustavo Pompermaier (2016)
      Increased matrix metalloproteinases (MMPs) activity is a hallmark of periapical granulomas. However, the factors underlying the MMPs expression modulation in healthy and diseased periapical tissues remains to be determined. ...
    • Sung, H. H.; Castro, I.; González, S.; Aguilera, S.; Smorodinsky, N. I.; Quest, Andrew F. G.; Bahamondes, V.; Alliende, C.; Cortés, J.; Molina, C.; Urzúa, U.; Barrera, M. J.; Hermoso Ramello, Marcela; Herrera, L.; Leyton, C.; González, M. J. (Blackwell, 2015)
      ORIGINAL ARTICLEMUC1/SEC and MUC1/Y overexpression is associatedwith inflammation in Sj€ogren’s syndromeHH Sung1,*, I Castro1,*, S Gonz alez2, S Aguilera3, NI Smorodinsky4, AFG Quest1,5, V Bahamondes1,C Alliende1, J Cort ...
    • Morselli, E.; Frank, A. P.; Palmer, B. F.; Rodriguez Navas, C.; Criollo Céspedes, Alfredo; Clegg, D. J. (Nature Publishing Group, 2016)
      In this review, we discuss the observations that, following chronic high-fat diet (HFD) exposure, male mice have higher levels of saturated fatty acids (FAs) and total sphingolipids, whereas lower amounts of polyunsaturated ...
    • Gómez Valenzuela, Fernán Daniel; Escobar López, Enrico Alejandro; Pérez Tomás, Ricardo; Montecinos, Viviana P. (Frontiers Media, 2021)
      The tumor microenvironment (TME) corresponds to a complex and dynamic interconnection between the extracellular matrix and malignant cells and their surrounding stroma composed of immune and mesenchymal cells. The TME ...
    • Farfan, Mauricio; Cantero, Lidia; Vergara, Alejandra; Vidal, Roberto; Torres, Alfredo (2013)
      Infection with Shiga toxin-producing Escherichia coli (STEC) O157:H7 is characterized by acute inflammation of the colonic mucosa. STEC O157:H7 contains two non-identical loci encoding long polar fimbriae (Lpf), which ...
    • Abusleme, Loreto; Dupuy, Amanda; Dutzan, Nicolás; Silva, Nora; Burleson, Joseph; Strausbaugh, Linda; Gamonal Aravena, Jorge; Diaz, Patricia (2013)
      The goals of this study were to better understand the ecology of oral subgingival communities in health and periodontitis and elucidate the relationship between inflammation and the subgingival microbiome. Accordingly, we ...