Browsing by Subject "Oral cancer"

Now showing items 1-10 of 10

    • Autophagy in aging-related oral diseases 
      Peña Oyarzún, Daniel; San Martin, Carla; Hernández Cáceres, María Paz; Lavandero González, Sergio Alejandro; Morselli, Eugenia; Budini Budini, Mauricio Fernando; Burgos, Patricia V.; Criollo Céspedes, Alfredo Guillermo (Frontiers Media, 2022)
      Autophagy is an intracellular degradation mechanism that allows recycling of organelles and macromolecules. Autophagic function increases metabolite availability modulating metabolic pathways, differentiation and cell ...
    • Expression profile of components of the beta-catenin destruction complex in oral dysplasia and oral cancer 
      Goñi, Francisca J.; Peña Oyarzún, Daniel Alejandro; Torres Gómez, Vicente A.; Reyes, Montserrat (Medicina Oral, 2021)
      Background: Oral cancer represents the sixth most common cancer in the world and is associated with 40-50% survival at 5 years. Within oral malignancies, oral squamous cell carcinoma (OSCC) is commonly preceded by potentially ...
    • Higher blood vessel density in comparison to the lymphatic vessels in oral squamous cell carcinoma 
      Maturana Ramírez, Andrea; Espinoza Santander, Iris; Reyes, Montserrat; Aitken, Juan Pablo; Aguayo, Francisco; Hartel, Steffen; Rojas Alcayaga, Gonzalo (E-Century Publishing Corp., 2015)
      Introduction: Oral squamous cell carcinoma (OSCC) is characterized by local invasion and the development of cervical metastasis. In the tongue, an association between the invasion of the lymphatic vessels and the development ...
    • Innate Phagocyte Polarization in the Oral Cavity 
      Metcalfe, Sarah; Anselmi, Natalie; Escobar Álvarez, Alejandro Felipe; Visser, Michelle B.; Kay, Jason G. (Frontiers Media, 2022)
      The oral cavity is a complex environment constantly exposed to antigens from food and the oral microbiota. Innate immune cells play an essential role in maintaining health and homeostasis in the oral environment. However, ...
    • Nuclear accumulation of beta-catenin is associated with endosomal sequestration of the destruction complex ... 
      Reyes Rojas, Montserrat; Peña Oyarzún, Daniel; Silva, Patricio; Venegas, Sebastián; Criollo Céspedes, Alfredo; Torres Gómez, Vicente (Wiley, 2020)
      Potentially malignant lesions, commonly referred to as dysplasia, are associated with malignant transformation by mechanisms that remain unclear. We recently reported that increased Wnt secretion promotes the nuclear ...
    • Nuclear localization of β-catenin and expression of target genes are associated with increased Wnt secretion ... 
      Reyes Rojas, Montserrat; Peña Oyarzún, Daniel; Maturana Ramírez, Andrea; Torres Gómez, Vicente (Elsevier, 2019)
      Objectives: To evaluate the localization of β-catenin in oral dysplastic cells, the expression of target genes upregulated in oral dysplasia, and the role of Wnt ligands in these events. Materials and methods: Subcellular ...
    • Oral cancer susceptibility associated with the CYP1A1 and GSTM1 genotypes in Chilean individuals 
      Cordero Torres, Karina Lizzy; Espinoza Santander, Iris; Cáceres Lillo, Dante; Roco, Angela; Miranda Melo, Carla Soledad; Squicciarini Rueda, Valentina; Santander Gallo, Paula Andrea; Kuen Shiou, Lee; Saavedra Saavedra, Iván; Quiñones Sepúlveda, Luis (Spandidos Publications, 2010-05)
      Polycyclic aromatic hydrocarbons (PAHs) contained in tobacco smoke acquire carcinogenicity following their activation by xenobiotic-metabolizing enzymes to highly reactive metabolites. The cytochrome P4501A1 (CYP1A1) enzyme ...
    • Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through ... 
      Nieminen, Mikko T.; Listyarifah, Dyah; Hagstrom, Jaana; Haglund, Caj; Grenier, Daniel; Nordstrom, Dan; Uitto, Veli-Jukka; Hernández Ríos, Emma; Yucel-Lindberg, Tulay; Tervahartiala, Taina; Ainola, Mari; Sorsa, Timo (Nature, 2018)
      Background: Periodontal pathogens have been linked to oral and gastrointestinal (orodigestive) carcinogenesis. However, the exact mechanisms remain unknown. Treponema denticola (Td) is associated with severe periodontitis, ...
    • Vascular endothelial growth factor: A translational view in oral non-communicable diseases 
      Niklander, Sven; Bordagaray San Martín, María José; Fernández, Alejandra; Hernández Ríos, Emma Marcela (MDPI, 2021)
      Vascular endothelial growth factors (VEGFs) are vital regulators of angiogenesis that are expressed in response to soluble mediators, such as cytokines and growth factors. Their physiologic functions include blood vessel ...
    • Wnt/beta-Catenin Signaling in Oral Carcinogenesis 
      Reyes Rojas, Montserrat; Flores Lillo, Tania; Betancur, Diego; Peña Oyarzún, Daniel; Torres Gómez, Vicente (MDPI, 2020)
      Oral carcinogenesis is a complex and multifactorial process that involves cumulative genetic and molecular alterations, leading to uncontrolled cell proliferation, impaired DNA repair and defective cell death. At the ...