Neurotoxicity of some MAO Inhibitors in Adult Rat Hypothalamic Cell Culture
Hurtado_Guzman_C.pdf (226.6Kb)Abstract
Monoamine oxidase-A (MAO-A) (amiflamine (AMF)
and 4-methylthioamphetamine (MTA)) and MAO-B (Ldeprenyl)
inhibitors were found to be cytotoxic in a
concentration-dependent manner for RCHTcells derived
from adult rat hypothalamus. The cytotoxic effects were
increased when the inhibitors were co-incubated with
dicoumarol and especially with 25mM AMF+100mM
dicoumarol (2.5-fold; P < 0.001). The treatment of RCHT
cells solely with AMF induced a marked decrease in the
expression of DT-diaphorase mRNA.
Patrocinador
This work was supported by FONDECYT grants NO
1990622, 1980906, 1000776 and ICM grant NO P99-
031-F.
Quote Item
Neurotoxicity Research, Vol. 4 (2), p. 161–163, 2002.
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