| Author | dc.contributor.author | Hurtado Guzmán, C. | |
| Author | dc.contributor.author | Martínez Alvarado, P. | es_CL |
| Author | dc.contributor.author | Dagnino Subiabre, A. | es_CL |
| Author | dc.contributor.author | Paris Pizarro, Irmgard | es_CL |
| Author | dc.contributor.author | Caviedes Fernández, Pablo | es_CL |
| Author | dc.contributor.author | Caviedes Codelia, Raúl | es_CL |
| Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
| Author | dc.contributor.author | Segura Aguilar, Juan | es_CL |
| Admission date | dc.date.accessioned | 2012-06-04T19:42:56Z | |
| Available date | dc.date.available | 2012-06-04T19:42:56Z | |
| Publication date | dc.date.issued | 2001-05-04 | |
| Cita de ítem | dc.identifier.citation | Neurotoxicity Research, Vol. 4 (2), p. 161–163, 2002. | es_CL |
| Identifier | dc.identifier.issn | 1476-3524 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119449 | |
| Abstract | dc.description.abstract | Monoamine oxidase-A (MAO-A) (amiflamine (AMF)
and 4-methylthioamphetamine (MTA)) and MAO-B (Ldeprenyl)
inhibitors were found to be cytotoxic in a
concentration-dependent manner for RCHTcells derived
from adult rat hypothalamus. The cytotoxic effects were
increased when the inhibitors were co-incubated with
dicoumarol and especially with 25mM AMF+100mM
dicoumarol (2.5-fold; P < 0.001). The treatment of RCHT
cells solely with AMF induced a marked decrease in the
expression of DT-diaphorase mRNA. | es_CL |
| Patrocinador | dc.description.sponsorship | This work was supported by FONDECYT grants NO
1990622, 1980906, 1000776 and ICM grant NO P99-
031-F. | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | Taylor & Francis Ltd | es_CL |
| Keywords | dc.subject | MAO inhibitors | es_CL |
| Título | dc.title | Neurotoxicity of some MAO Inhibitors in Adult Rat Hypothalamic Cell Culture | es_CL |
| Document type | dc.type | Artículo de revista | |
