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Nitrofurylsemicarbazone rhenium and ruthenium complexes as anti-trypanosomal agents

Authordc.contributor.authorOtero, Lucía 
Authordc.contributor.authorAguirre, Gabriela es_CL
Authordc.contributor.authorBoiani, Lucía es_CL
Authordc.contributor.authorDenicola, Ana es_CL
Authordc.contributor.authorRigol Olsen, Carolina es_CL
Authordc.contributor.authorOlea Azar, Claudio es_CL
Authordc.contributor.authorMaya Arango, Juan es_CL
Authordc.contributor.authorMorello Casté, Antonio es_CL
Authordc.contributor.authorGonzález, Mercedes es_CL
Authordc.contributor.authorGambino, Dinorah es_CL
Authordc.contributor.authorCerecetto, Hugo es_CL
Admission datedc.date.accessioned2009-06-05T12:49:52Z
Available datedc.date.available2009-06-05T12:49:52Z
Publication datedc.date.issued2006-11
Cita de ítemdc.identifier.citationEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 41 Issue: 11 Pages: 1231-1239 Published: NOV 2006en
Identifierdc.identifier.issn0223-5234
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/120659
Abstractdc.description.abstractRhenium and ruthenium complexes of the type [(ReOCl2)-O-V(PPh3)L] and [(RuC2)-C-II(DMSO)(2)L], where L are 5-nitroftitylsemicarbazone derivatives, were prepared in an effort to obtain new anti-trypanosomal agents combining the recognized biological activity of these metals and the trypanocidal activity of the free ligands. Rhenium complexes resulted unstable in aqueous solution not allowing their use as potential drugs. On the other hand, complexation to ruthenium of the bioactive ligands lead to the lack of antiprotozoa activity even though free radical production and redox cycling induction were detected when the compounds were incubated in presence of Trypanosoma cruzi cells. The lack of anti-trypanosomal activity of ruthenium complexes could be explained on the basis of their high protein binding capacity and their high hydrophilicity.en
Lenguagedc.language.isoenen
Publisherdc.publisherELSEVIERen
Keywordsdc.subject5-NITROTHIOPHENE-2-CARBOXALDEHYDE SEMICARBAZONE DERIVATIVESen
Títulodc.titleNitrofurylsemicarbazone rhenium and ruthenium complexes as anti-trypanosomal agentsen
Document typedc.typeArtículo de revistaen


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