Is a 40 % Absorption of Iron from a Ferrous Ascorbate Reference Dose Appropriate to Assess Iron Absorption Independent of Iron Status?
Author
dc.contributor.author
Valenzuela Venegas, Carolina
Author
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Olivares Grohnert, Manuel
es_CL
Author
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Brito, Alex
es_CL
Author
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Hamilton-West Miranda, Christopher
es_CL
Author
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Pizarro Aguirre, Fernando
es_CL
Admission date
dc.date.accessioned
2014-01-09T13:44:58Z
Available date
dc.date.available
2014-01-09T13:44:58Z
Publication date
dc.date.issued
2013
Cita de ítem
dc.identifier.citation
Biol Trace Elem Res (2013) 155:322–326
en_US
Identifier
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DOI 10.1007/s12011-013-9797-2
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/122509
General note
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Artículo de publicación ISI
en_US
Abstract
dc.description.abstract
Although a 40%absorption of a standard reference
dose corresponds to iron (Fe) absorption in borderline Fedeficient
subjects, this percentage is currently applied to all
subjects independent of Fe status: (a) to assess the use of the
40 % of Fe absorption of the reference dose (FeRD%) for
subjects with iron-depleted stores (IDS), normal Fe status
(NIS), Fe deficiency without anemia (IDWA), and Fe deficiency
anemia (IDA) and (b) to explore relationships between
Fe status biomarkers and FeRD%. Six hundred forty-six participants
(582 women and 64 men) were selected from multiple
Fe bioavailability studies and classified into four groups
based on Fe status: NIS, IDS, IDWA, and IDA. All men were
classified as normal. The absorption from FeRD% was calculated
in each group and correlated with Fe status biomarkers.
(a) Women with IDS absorbed 40 (18.9–84.7)% of the reference
dose; (b) for male subjects with NIS, the absorption of
the reference dose was 19 (9.8–36.1)%, while for females,
absorption was observed as to be 34 (16.7–68.6)%. In the case
of subjects with IDWA, a 43 (19.7–92.5)% absorption was
observed, while subjects with IDA demonstrated 67 (45.2–
98.6)% absorption. Serum ferritin (SF) had the strongest
inverse correlation with FeRD% (r =−0.41, p <0.001). A
transferrin saturation (TS) <15 % increases the probability
that the FeRD% will be highly elevated (OR, 5.05; 95 % CI, 2.73, 9.31; p <0.001). A 40 % absorption as reference dose is
only appropriate to assess Fe absorption in subjects with IDS
and IDWA. SF had an inverse correlation with FeRD%, and
TS increases the probability that the FeRD% will be elevated
by over fivefold.