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Association between the occurrence of matrix metalloproteinases 2 and 9 in parotid saliva with the degree of parotid gland damage in juvenile recurrent parotitis

Authordc.contributor.authorMorales Bozo, Irene 
Authordc.contributor.authorLandaeta, Mirtha es_CL
Authordc.contributor.authorUrzúa Orellana, Blanca es_CL
Authordc.contributor.authorRetamales Molina, Patricio es_CL
Admission datedc.date.accessioned2010-01-18T19:47:53Z
Available datedc.date.available2010-01-18T19:47:53Z
Publication datedc.date.issued2008-09
Cita de ítemdc.identifier.citationORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY Volume: 106 Issue: 3 Pages: 377-383 Published: SEP 2008en_US
Identifierdc.identifier.issn1079-2104
Identifierdc.identifier.other10.1016/j.tripleo.2008.02.006
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/123351
Abstractdc.description.abstractObjective: The study was aimed to investigate whether the occurrence of matrix metalloproteinases (MMP) 2 and 9 in parotid saliva of juvenile recurrent parotitis (JRP) patients is associated with the degree of glandular involvement. Study design. Thirty-three JRP patients were included. Involvement of parotid gland was assessed by sialography. Parotid saliva was assayed for MMP-2 and MMP-9 by zymography. Medical charts were examined for number of recurrences, disease laterality, and time of follow-up. Logistic regression analysis between occurrence of either MMP, the clinical parameters, and sialographic staging was conducted. Results. None of the clinical parameters under analysis were found to be associated with degree of sialographic involvement. Statistical associations were found between presence of MMP-9 and MMP-2 in parotid saliva and sialographic stage (P = .017; odds ratio [OR] 6.5, 95% confidence interval [CI] 1.4-30.4; and P = .009; OR 6.1; 95% CI 1.6-23.7; respectively). Conclusions. Occurrence frequency of MMP-2 and MMP-9 in parotid saliva from affected glands of JRP patients was associated with degree of gland damage.en_US
Patrocinadordc.description.sponsorshipThis study was supported in part by University of Chile grants DI-MULT 06/14-2 and DI-MULT 05/35-2.en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherMOSBY-ELSEVIERen_US
Keywordsdc.subjectSELECTIVE IGA DEFICIENCYen_US
Títulodc.titleAssociation between the occurrence of matrix metalloproteinases 2 and 9 in parotid saliva with the degree of parotid gland damage in juvenile recurrent parotitisen_US
Document typedc.typeArtículo de revistaen_US


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