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Control of calcium oxalate morphology through electrocrystallization as an electrochemical approach for preventing pathological disease

Authordc.contributor.authorNeira Carrillo, Andrónico 
Authordc.contributor.authorVásquez Quitral, Patricio 
Authordc.contributor.authorSánchez, Marianela 
Authordc.contributor.authorVargas Fernández, Andrés 
Authordc.contributor.authorSilva, Juan Francisco 
Admission datedc.date.accessioned2015-12-11T18:32:20Z
Available datedc.date.available2015-12-11T18:32:20Z
Publication datedc.date.issued2015
Cita de ítemdc.identifier.citationIonics (2015) 21:3141–3149en_US
Identifierdc.identifier.otherDOI 10.1007/s11581-015-1558-0
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/135646
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractPathological crystallization of calcium oxalate (CaOx) inside the urinary tract is called calculi or kidney stone (Urolithiasis). CaOx exhibits three crystalline types in nature: CaOx monohydrate COM, dihydrate COD and trihydrate COT. COD and COM are often found in urinary calculi, particularly COM. Electrocrystallization has been recently used to perform oriented crystallization of inorganic compounds such as Ca-salts. Although many mineralization methods exist, the mechanisms involved in the control of CaOx polymorphism still remain unclear. Herein, we induced selective electrocrystallization of COD by modifying the electrical current, time and electrochemical cell type. By combining above factors, we established an efficient method without the use of additives for stabilizing non-pathological CaOx crystals. We found notorious stabilization of CaOx polymorphisms with hierarchically complex shape with nano-organization assembly, size and aggregated crystalline particles. Our results demonstrated that, by using an optimized electrochemical approach, this technique could have great potential for studying the nucleation and crystal growth of CaOx through functionalized synthetic polymers, and to develop a novel pathway to evaluate new calculi preventing-compound inhibitors.en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherSpringeren_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Keywordsdc.subjectMineralizationen_US
Keywordsdc.subjectElectrocrystallizationen_US
Keywordsdc.subjectUrolitiasisen_US
Keywordsdc.subjectCalcium oxalateen_US
Keywordsdc.subjectPolymorphismen_US
Títulodc.titleControl of calcium oxalate morphology through electrocrystallization as an electrochemical approach for preventing pathological diseaseen_US
Document typedc.typeArtículo de revistaen_US


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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile