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Reporting, handling and assessing the risk of bias associated with missing participant data in systematic reviews: a methodological survey

Authordc.contributor.authorAkl, Elie A. 
Authordc.contributor.authorCarrasco Labra, Alonso 
Authordc.contributor.authorBrignardello Petersen, Romina 
Authordc.contributor.authorNeumann, Ignacio 
Authordc.contributor.authorJohnston, Bradley C. 
Authordc.contributor.authorSun, Xin 
Authordc.contributor.authorBriel, Matthias 
Authordc.contributor.authorBusse, Jason W. 
Authordc.contributor.authorEbrahim, Shanil 
Authordc.contributor.authorGranados, Carlos E. 
Authordc.contributor.authorIorio, Alfonso 
Authordc.contributor.authorIrfan, Affan 
Authordc.contributor.authorMartínez García, Laura 
Authordc.contributor.authorMustafa, Reem A. 
Authordc.contributor.authorRamírez Morera, Anggie 
Authordc.contributor.authorSelva, Anna 
Authordc.contributor.authorSolà, Iván 
Authordc.contributor.authorSanabria, Andrea Juliana 
Authordc.contributor.authorTikkinen, Kari A. O. 
Authordc.contributor.authorVandvik, Per O. 
Authordc.contributor.authorVernooij, Robin W. M. 
Authordc.contributor.authorZazueta, Oscar E. 
Authordc.contributor.authorZhou, Qi 
Authordc.contributor.authorGuyatt, Gordon H. 
Authordc.contributor.authorAlonso Coello, Pablo 
Cita de ítemdc.identifier.citationBMJ Open 2015; 5: e009368en_US
Identifierdc.identifier.otherDOI: 10.1136/bmjopen-2015-009368
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractObjectives: To describe how systematic reviewers are reporting missing data for dichotomous outcomes, handling them in the analysis and assessing the risk of associated bias. Methods: We searched MEDLINE and the Cochrane Database of Systematic Reviews for systematic reviews of randomised trials published in 2010, and reporting a meta-analysis of a dichotomous outcome. We randomly selected 98 Cochrane and 104 non-Cochrane systematic reviews. Teams of 2 reviewers selected eligible studies and abstracted data independently and in duplicate using standardised, piloted forms with accompanying instructions. We conducted regression analyses to explore factors associated with using complete case analysis and with judging the risk of bias associated with missing participant data. Results: Of Cochrane and non-Cochrane reviews, 47% and 7% (p<0.0001), respectively, reported on the number of participants with missing data, and 41% and 9% reported a plan for handling missing categorical data. The 2 most reported approaches for handling missing data were complete case analysis (8.5%, out of the 202 reviews) and assuming no participants with missing data had the event (4%). The use of complete case analysis was associated only with Cochrane reviews (relative to non-Cochrane: OR=7.25; 95% CI 1.58 to 33.3, p=0.01). 65% of reviews assessed risk of bias associated with missing data; this was associated with Cochrane reviews (relative to non-Cochrane: OR=6.63; 95% CI 2.50 to 17.57, p=0.0001), and the use of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology (OR=5.02; 95% CI 1.02 to 24.75, p=0.047). Conclusions: Though Cochrane reviews are somewhat less problematic, most Cochrane and non-Cochrane systematic reviews fail to adequately report and handle missing data, potentially resulting in misleading judgements regarding risk of bias.en_US
Patrocinadordc.description.sponsorshipMiguel Servet research contract from the Instituto de Salud Carlos III CP09/00137 Rio Hortega research contract from the Instituto de Salud Carlos III CM10/00014 CM12/00168en_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjectAddressing continuous dataen_US
Keywordsdc.subjectTrials lost-iten_US
Keywordsdc.subjectPotential impacten_US
Títulodc.titleReporting, handling and assessing the risk of bias associated with missing participant data in systematic reviews: a methodological surveyen_US
Document typedc.typeArtículo de revistaen_US

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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile