Show simple item record

Systematic reviews experience major limitations in reporting absolute effects

Authordc.contributor.authorAlonso Coello, Pablo 
Authordc.contributor.authorCarrasco Labra, Alonso 
Authordc.contributor.authorBrignardello Petersen, Romina 
Authordc.contributor.authorNeumann, Ignacio 
Authordc.contributor.authorAkl, Elie 
Authordc.contributor.authorVernooij, Robin 
Authordc.contributor.authorJohnston, Brad 
Authordc.contributor.authorSun, Xin 
Authordc.contributor.authorBriel, Matthias 
Authordc.contributor.authorBusse, Jason 
Authordc.contributor.authorEbrahim, Shanil 
Authordc.contributor.authorGranados, Carlos 
Authordc.contributor.authorIorio, Alfonso 
Authordc.contributor.authorIrfan, Affan 
Authordc.contributor.authorMartínez García, Laura 
Authordc.contributor.authorMustafa, Reem 
Authordc.contributor.authorRamírez Morers, Anggie 
Authordc.contributor.authorSelva, Anna 
Authordc.contributor.authorSolà, Iván 
Authordc.contributor.authorSanabria, Andrea 
Authordc.contributor.authorTikkinen, Kari 
Authordc.contributor.authorVandvik, Per 
Authordc.contributor.authorZazueta, Oscar 
Authordc.contributor.authorZhang, Yuqing 
Authordc.contributor.authorZhou, Qi 
Authordc.contributor.authorSchünemann, Holger 
Authordc.contributor.authorGuyatt, Gordon H. 
Admission datedc.date.accessioned2016-06-30T22:34:16Z
Available datedc.date.available2016-06-30T22:34:16Z
Publication datedc.date.issued2016
Cita de ítemdc.identifier.citationJournal of Clinical Epidemiology 72 (2016) 16-26en_US
Identifierdc.identifier.issn0895-4356
Identifierdc.identifier.otherDOI: 10.1016/j.jclinepi.2015.11.002
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/139327
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractObjectives: Expressing treatment effects in relative terms yields larger numbers than expressions in absolute terms, affecting the judgment of the clinicians and patients regarding the treatment options. It is uncertain how authors of systematic reviews (SRs) absolute effect estimates are reported in. We therefore undertook a systematic survey to identify and describe the reporting and methods for calculating absolute effect estimates in SRs. Study Design and Setting: Two reviewers independently screened title, abstract, and full text and extracted data from a sample of Cochrane and non-Cochrane SRs. We used regression analyses to examine the association between study characteristics and the reporting of absolute estimates for the most patient-important outcome. Results: We included 202 SRs (98 Cochrane and 104 non-Cochrane), most of which (92.1%) included standard meta-analyses including relative estimates of effect. Of the 202 SRs, 73 (36.1%) reported absolute effect estimates for the most patient-important outcome. SRs with statistically significant effects were more likely to report absolute estimates (odds ratio, 2.26; 95% confidence interval: 1.08, 4.74). The most commonly reported absolute estimates were: for each intervention, risk of adverse outcomes expressed as a percentage (41.1%); number needed to treat (26.0%); and risk for each intervention expressed as natural units or natural frequencies (24.7%). In 12.3% of the SRs that reported absolute effect estimates for both benefit and harm outcomes, harm outcomes were reported exclusively as absolute estimates. Exclusively reporting of beneficial outcomes as absolute estimates occurred in 6.8% of the SRs. Conclusions: Most SRs do not report absolute effects. Those that do often report them inadequately, thus requiring users of SRs to generate their own estimates of absolute effects. For any apparently effective or harmful intervention, SR authors should report both absolute and relative estimates to optimize the interpretation of their findings.en_US
Patrocinadordc.description.sponsorshipMiguel Servet research contract from the Instituto de Salud Carlos III CP09/00137 Rio Hortega research contract from the Instituto de Salud Carlos III CM10/00014 CM12/00168 santesuisse Gottfried and Julia Bangerter-Rhyner Foundation Canadian Chiropractic Research Foundation Academy of Finland 276046 Canadian Institutes of Health Research Helsinki and Uusimaa Hospital District Finnish Cultural Foundation Finnish Medical Foundation Jane and Aatos Erkko Foundation Sigrid Juselius Foundationen_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherElsevieren_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Keywordsdc.subjectAbsolute measuresen_US
Keywordsdc.subjectAbsolute effect estimatesen_US
Keywordsdc.subjectSystematic reviewen_US
Keywordsdc.subjectReportingen_US
Keywordsdc.subjectFramingen_US
Keywordsdc.subjectRisk differenceen_US
Keywordsdc.subjectDecision makingen_US
Títulodc.titleSystematic reviews experience major limitations in reporting absolute effectsen_US
Document typedc.typeArtículo de revistaen_US


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record

Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile