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Clinical Effects of Lactobacillus rhamnosus in Non-Surgical Treatment of Chronic Periodontitis: A Randomized Placebo-Controlled Trial With 1-Year Follow-Up

Authordc.contributor.authorMorales, Alicia 
Authordc.contributor.authorCarvajal, Paola 
Authordc.contributor.authorSilva, Nora 
Authordc.contributor.authorHernández, Marcela 
Authordc.contributor.authorGodoy González, Claudia Andrea 
Authordc.contributor.authorRodríguez, Gonzalo 
Authordc.contributor.authorCabello Ibacache, Rodrigo Antonio 
Authordc.contributor.authorGarcía Sesnich, Jocelyn Nata 
Authordc.contributor.authorHoare, Anilei 
Authordc.contributor.authorDíaz, Patricia I. 
Authordc.contributor.authorGamonal Aravena, Jorge Antonio 
Cita de ítemdc.identifier.citationJournal of Periodontology. Volumen: 87 Número: 8 Páginas: 944-952es_ES
Abstractdc.description.abstractBackground: Probiotics are living microorganisms that provide beneficial effects for the host when administered in proper quantities. The aim of this double-masked placebo-controlled parallel-arm randomized clinical trial is to evaluate the clinical effects of a Lactobacillus rhamnosus SP1-containing probiotic sachet as an adjunct to non-surgical therapy. Methods: Twenty-eight systemically healthy volunteers with chronic periodontitis were recruited and monitored clinically at baseline and 3, 6, 9, and 12 months after therapy. Clinical parameters measured included plaque accumulation, bleeding on probing, probing depths (PDs), and clinical attachment loss. Patients received non-surgical therapy, including scaling and root planing (SRP), and were assigned randomly to a test (SRP + probiotic, n = 14) or control (SRP + placebo, n = 14) group. The intake, once a day for 3 months, of an L. rhamnosus SP1 probiotic sachet commenced after the last session of SRP. Results: Both test and control groups showed improvements in clinical parameters at all time points evaluated. However, the test group showed greater reductions in PD than the control. Also, at initial visits and after 1-year follow-up, the test group showed a statistically significant reduction in the number of participants with PD >= 6 mm, indicating a reduced need for surgery, in contrast to the placebo group. Conclusion: The results of this trial indicate that oral administration of L. rhamnosus SP1 resulted in similar clinical improvements compared with SRP alone.es_ES
Patrocinadordc.description.sponsorshipNational Fund for Scientific and Technological Development Project, CONICYT-PCHA/National Magisteres_ES
Publisherdc.publisherAmer Physical Soc.es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceJournal of Periodontologyes_ES
Keywordsdc.subjectroot planinges_ES
Keywordsdc.subjectLactobacillus rhamnosuses_ES
Keywordsdc.subjectChronic periodontitises_ES
Títulodc.titleClinical Effects of Lactobacillus rhamnosus in Non-Surgical Treatment of Chronic Periodontitis: A Randomized Placebo-Controlled Trial With 1-Year Follow-Upes_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorC. R. B.es_ES
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile