Application of minimal important differences in degenerative knee disease outcomes: a systematic review and case study to inform BMJ Rapid Recommendations
Author
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Devji, Tahira
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Guyatt, Gordon H.
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Lytvyn, Lyubov
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Brignardello Petersen, Romina
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Foroutan, Farid
Author
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Sadeghirad, Behnam
Author
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Buchbinder, Rachelle
Author
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Poolman, Rudolf W.
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Harris, Ian A.
Author
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Carrasco Labra, Alonso
Author
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Siemieniuk, Reed A. C.
Author
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Vandvik, Per O.
Admission date
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2018-04-19T12:55:07Z
Available date
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2018-04-19T12:55:07Z
Publication date
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2017
Cita de ítem
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BMJ Open 2017;7:e015587
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Identifier
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10.1136/bmjopen-2016-015587
Identifier
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https://repositorio.uchile.cl/handle/2250/147312
Abstract
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Objectives: To identify the most credible anchor-based minimal important differences (MIDs) for patient important outcomes in patients with degenerative knee disease, and to inform BMJ Rapid Recommendations for arthroscopic surgery versus conservative management
Design: Systematic review.
Outcome measures: Estimates of anchor-based MIDs, and their credibility, for knee symptoms and health-related quality of life (HRQoL).
Data sources: MEDLINE, EMBASE and PsycINFO.
Eligibility criteria: We included original studies documenting the development of anchor-based MIDs for patient-reported outcomes (PROs) reported in randomised controlled trials included in the linked systematic review and meta-analysis and judged by the parallel BMJ Rapid Recommendations panel as critically important for informing their recommendation: measures of pain, function and HRQoL.
Results: 13 studies reported 95 empirically estimated anchor-based MIDs for 8 PRO instruments and/or their subdomains that measure knee pain, function or HRQoL. All studies used a transition rating (global rating of change) as the anchor to ascertain the MID. Among PROs with more than 1 estimated MID, we found wide variation in MID values. Many studies suffered from serious methodological limitations. We identified the following most credible MIDs: Western Ontario and McMaster University Osteoarthritis Index (WOMAC; pain: 12, function: 13), Knee injury and Osteoarthritis Outcome Score (KOOS; pain: 12, activities of daily living: 8) and EuroQol five dimensions Questionnaire (EQ-5D; 0.15).
Conclusions: We were able to distinguish between more and less credible MID estimates and provide best estimates for key instruments that informed evidence presentation in the associated systematic review and judgements made by the Rapid Recommendation panel.
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Patrocinador
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Canadian Institutes of Health Research
DC0190SR
Australian National Health and Medical Research Council (NHMRC)
Application of minimal important differences in degenerative knee disease outcomes: a systematic review and case study to inform BMJ Rapid Recommendations