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Determination of chlortetracycline residues, antimicrobial activity and presence of resistance genes in droppings of experimentally treated broiler chickens

Authordc.contributor.authorCornejo Kelly, Javiera 
Authordc.contributor.authorYevenes, Karina 
Authordc.contributor.authorAvello Lefno, Constanza 
Authordc.contributor.authorPokrant Huerta, Ekaterina 
Authordc.contributor.authorMaddaleno Toledo, Aldo 
Authordc.contributor.authorSan Martín Núñez, Betty 
Authordc.contributor.authorLapierre Acevedo, Lisette 
Cita de ítemdc.identifier.citationMolecules 2018, 23,1264es_ES
Abstractdc.description.abstractTetracyclines are important antimicrobial drugs for poultry farming that are actively excreted via feces and urine. Droppings are one of the main components in broiler bedding, which is commonly used as an organic fertilizer. Therefore, bedding becomes an unintended carrier of antimicrobial residues into the environment and may pose a highly significant threat to public health. For this depletion study, 60 broiler chickens were treated with 20% chlortetracycline (CTC) under therapeutic conditions. Concentrations of CTC and 4-epi-CTC were then determined in their droppings. Additionally, this work also aimed to detect the antimicrobial activity of these droppings and the phenotypic susceptibility to tetracycline in E. coli isolates, as well as the presence of tet(A), tet(B), and tet(G) resistance genes. CTC and 4-epi-CTC concentrations that were found ranged from 179.5 to 665.8 mu g/kg. Based on these data, the depletion time for chicken droppings was calculated and set at 69 days. All samples presented antimicrobial activity, and a resistance to tetracyclines was found in bacterial strains that were isolated from these samples. Resistance genes tet(A) and tet(B) were also found in these samples.es_ES
Patrocinadordc.description.sponsorshipThis work was supported by the University of Chile [Project U Inicia 2013] and by the IAEA Research contract 22180, under the Coordinated Research Project D52041. The authors appreciate the collaboration of Mr. Rodrigo Gambra in the translation of this manuscript. The authors state that they did not receive specific funds for covering the costs to publish as open access.es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjecttetracycline residueses_ES
Keywordsdc.subjectpoultry droppingses_ES
Keywordsdc.subjectantimicrobial activityes_ES
Keywordsdc.subjectantimicrobial resistance geneses_ES
Títulodc.titleDetermination of chlortetracycline residues, antimicrobial activity and presence of resistance genes in droppings of experimentally treated broiler chickenses_ES
Document typedc.typeArtículo de revistaes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile