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Genetic analysis of porcine circovirus type 2 from pigs affected with PMWS in Chile reveals intergenotypic recombination

Authordc.contributor.authorNeira Ramírez, Victor 
Authordc.contributor.authorRamos, Natalia 
Authordc.contributor.authorTapia Tapia, Rodrigo 
Authordc.contributor.authorArbiza, Juan 
Authordc.contributor.authorNeira Carrillo, Andrónico 
Authordc.contributor.authorQuezada, Manuel 
Authordc.contributor.authorRuiz, Álvaro 
Authordc.contributor.authorBucarey Vivanco, Sergio 
Admission datedc.date.accessioned2018-12-20T14:52:41Z
Available datedc.date.available2018-12-20T14:52:41Z
Publication datedc.date.issued2017
Cita de ítemdc.identifier.citationVirology Journal, Volumen 14, Issue 1, 2017, Article number 191
Identifierdc.identifier.issn1743422X
Identifierdc.identifier.other10.1186/s12985-017-0850-1
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/157180
Abstractdc.description.abstractBackground: Porcine circovirus type 2 (PCV2) is a very small, non-enveloped and icosahedral virus, with circular single stranded DNA genome. This virus is the most ubiquitous and persistent pathogen currently affecting the swine industry worldwide. PCV2 has been implicated as the major causative agent of postweaning multisystemic wasting syndrome (PMWS), a disease which is characterized by severe immunosuppressive effects in the porcine host. Worldwide PCV2 isolates have been classified into four different genotypes, PCV2a, PCV2b, PCV2c and PCVd. The goal of this work was to conduct the first phylogenetic analysis of PCV2 in Chile. Methods: PCV2 partial ORF2 sequences (462 nt) obtained from 29 clinical cases of PMWS in 22 Chilean intensive swine farms, covering over the 90% of the local pork-production, were analyzed. Results: 14% and 52% of sequences belonged to the genotypes PCV2a and PCV2b, respectively. Surprisingly, 34% of sequences were PCV2a/PCV2d recombinant viruses. Conclusions: Our findings suggested that a novel cluster of Chilean sequences emerged resulting from intergenotypic recombination between PCV2a and PCV2d
Lenguagedc.language.isoen
Publisherdc.publisherBioMed Central Ltd.
Sourcedc.sourceVirology Journal
Keywordsdc.subjectGenetic diversity
Keywordsdc.subjectPCV2
Keywordsdc.subjectPMWS
Keywordsdc.subjectRecombination
Títulodc.titleGenetic analysis of porcine circovirus type 2 from pigs affected with PMWS in Chile reveals intergenotypic recombination
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorapc
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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