Experimental cardio-depressant effects of clonixin
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1. 1. The cardiovascular effects of CLX were studied. 2. 2. CLX induced hypotension, bradycardia, negative chronotropism and negative inotropism. 3. 3. Electrophysiological studies showed a decrease of sinus venosus discharge frequency. The action potential configuration was changed: the overshoot amplitude and (dV/dt)max were reduced and duration increased. 4. 4. CLX at higher concentrations displaced the maximum diastolic potential and phase 4 slow diastolic depolarization was lengthened. 5. 5. The above findings could be explained by a depressant action of CLX on the electrical activity of the pacemaker cells, possibly by a modification of the slow calcium currents. © 1989.
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