Experimental cardio-depressant effects of clonixin
Author
dc.contributor.author
Bustamante, D.
Author
dc.contributor.author
Morales, M.
Author
dc.contributor.author
Pelissier Serrano, Teresa
Author
dc.contributor.author
Saavedra, H.
Author
dc.contributor.author
Miranda, H.
Author
dc.contributor.author
Paeile, C.
Admission date
dc.date.accessioned
2018-12-20T15:05:11Z
Available date
dc.date.available
2018-12-20T15:05:11Z
Publication date
dc.date.issued
1989
Cita de ítem
dc.identifier.citation
General Pharmacology, Volumen 20, Issue 5, 1989, Pages 605-608
Identifier
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03063623
Identifier
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10.1016/0306-3623(89)90094-3
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/157705
Abstract
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1. The cardiovascular effects of CLX were studied. 2. CLX induced hypotension, bradycardia, negative chronotropism and negative inotropism. 3. Electrophysiological studies showed a decrease of sinus venosus discharge frequency. The action potential configuration was changed: the overshoot amplitude and (dV/dt)max were reduced and duration increased. 4. CLX at higher concentrations displaced the maximum diastolic potential and phase 4 slow diastolic depolarization was lengthened. 5. The above findings could be explained by a depressant action of CLX on the electrical activity of the pacemaker cells, possibly by a modification of the slow calcium currents.