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Experimental cardio-depressant effects of clonixin

Authordc.contributor.authorBustamante, D. 
Authordc.contributor.authorMorales, M. 
Authordc.contributor.authorPelissier, T. 
Authordc.contributor.authorSaavedra, H. 
Authordc.contributor.authorMiranda, H. 
Authordc.contributor.authorPaeile, C. 
Admission datedc.date.accessioned2018-12-20T15:05:11Z
Available datedc.date.available2018-12-20T15:05:11Z
Publication datedc.date.issued1989
Cita de ítemdc.identifier.citationGeneral Pharmacology, Volumen 20, Issue 5, 1989, Pages 605-608
Identifierdc.identifier.issn03063623
Identifierdc.identifier.other10.1016/0306-3623(89)90094-3
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/157705
Abstractdc.description.abstract1. The cardiovascular effects of CLX were studied. 2. CLX induced hypotension, bradycardia, negative chronotropism and negative inotropism. 3. Electrophysiological studies showed a decrease of sinus venosus discharge frequency. The action potential configuration was changed: the overshoot amplitude and (dV/dt)max were reduced and duration increased. 4. CLX at higher concentrations displaced the maximum diastolic potential and phase 4 slow diastolic depolarization was lengthened. 5. The above findings could be explained by a depressant action of CLX on the electrical activity of the pacemaker cells, possibly by a modification of the slow calcium currents.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceGeneral Pharmacology
Keywordsdc.subjectPharmacology
Títulodc.titleExperimental cardio-depressant effects of clonixin
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorrvh
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile